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cross-coupling

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38

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15

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-21623
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct

    		Biochemical Assay Reagents Others
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a common dichloromethane solvate of the palladium catalyst Pd(dppf)Cl2, a phosphine ligand palladium(II) complex, which can be used as a versatile precatalyst for various cross-coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can stabilize reaction intermediates and lower the reaction activation energy in coupling reactions, and can be used in Suzuki-Miyaura coupling reaction studies .
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct
  • HY-114362
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate

    TPGS-750-M

    		 Biochemical Assay Reagents Others
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids .
    DL-alpha-Tocopherol methoxypolyethylene glycol succinate
  • HY-42487B
    (R)-Exatecan Intermediate 1

    		Drug Intermediate ADC Payload Topoisomerase Cancer
    (R)-Exatecan Intermediate 1 is a key intermediate in the synthesis of Camptothecin (HY-16560) derivatives, and can be used to prepare Exatecan mesylate (DX8951f) (HY-13631A). (R)-Exatecan Intermediate 1 enables the synthesis of Exatecan, which exhibits low sensitivity to multidrug resistance and has great value in anti-tumor research .
    (R)-Exatecan Intermediate 1
  • HY-W003165
    3-Bromo-5-chloropyridine

    		Biochemical Assay Reagents Others
    3-Bromo-5-chloropyridine is a widely used heterocyclic compound that can be used to synthesize compounds. 3-Bromo-5-chloropyridine can be used as an intermediate in the production of crop protectants in the agricultural chemicals industry. 3-Bromo-5-chloropyridine can participate in cross-coupling reactions .
    3-Bromo-5-chloropyridine
  • HY-W001242
    1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester

    		Biochemical Assay Reagents Drug Intermediate Others
    1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors .
    1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester
  • HY-W002570
    2-Naphthylboronic acid

    		Biochemical Assay Reagents Others
    2-Naphthylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Naphthylboronic acid can undergo silylation reaction. 2-Naphthylboronic acid also readily undergo Suzuki-Miyaura cross-coupling .
    2-Naphthylboronic acid
  • HY-30014
    4-Bromo-7-azaindole
    1 Publications Verification

    		 Drug Intermediate Others
    4-Bromo-7-azaindole is a brominated derivative of 7-azaindole. 4-Bromo-7-azaindole serves as a substrate for palladium-catalyzed C-N and C-O cross-coupling reactions, reacting with amides, amines, amino acid esters and phenols .
    4-Bromo-7-azaindole
  • HY-W013726
    Fmoc-Phe(4-Br)-OH

    		Biochemical Assay Reagents Amino Acid Derivatives Others
    Fmoc-Phe(4-Br)-OH is a widely used amino acid derivative. Fmoc-Phe(4-Br)-OH can be used in the synthesis of compounds and for the study of protein-protein interactions and the development of biomaterials. Fmoc-Phe(4-Br)-OH can be used in peptide synthesis to incorporate phenylalanine bromide into the peptide chain .
    Fmoc-Phe(4-Br)-OH
  • HY-W003601
    2-Bromo-4-fluoropyridine

    		Biochemical Assay Reagents Others
    2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.
    2-Bromo-4-fluoropyridine
  • HY-W033277
    Tetrakis(acetonitrile)palladium(II) tetrafluoroborate

    NSC 307191; Palladium(II) tetrafluoroborate tetraacetonitrile complex

    		 Drug Intermediate Endogenous Metabolite Others
    Tetrakis(acetonitrile)palladium(II) tetrafluoroborate (NSC 307191) acts as a potent Lewis acid and facilitates the formation of the 2:1 complex [Pd(1,2-bis(2′-pyridylethynyl)benzene)2](BF4)2 through the Sonogashira cross-coupling reaction.
    Tetrakis(acetonitrile)palladium(II) tetrafluoroborate
  • HY-75129
    Pyridin-3-ylboronic acid

    		Biochemical Assay Reagents Others
    Pyridin-3-ylboronic acid is an organic compound. Pyridin-3-ylboronic acid is a key reagent in the Suzuki-Miyaura cross-coupling reaction. Pyridin-3-ylboronic acid is used in organic synthesis to construct oligopyridine compounds, and then as an α-helix mimetic to study protein-protein interactions .
    Pyridin-3-ylboronic acid
  • HY-59162
    2,6-Dibromopyridine

    		Drug Intermediate Others
    2,6-Dibromopyridine is a drug intermediate that can be used for the synthesis of IRK-4 inhibitors.
    2,6-Dibromopyridine
  • HY-101974
    Biotin-PEG3-Bromide

    		Biochemical Assay Reagents Others
    Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.
    Biotin-PEG3-Bromide
  • HY-32746
    5-Bromo-2-fluoropyridine

    		Biochemical Assay Reagents Others
    5-Bromo-2-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 5-Bromo-2-fluoropyridine easily reacts with amines to synthesize halogenated pyridine and pyrimidine. 5-Bromo-2-fluoropyridine can be used as a model substrate to explore their efficiency and selectivity through successive SNAr substitution reactions and transition-metal-catalyzed cross-coupling reaction without an intervening purification step .
    5-Bromo-2-fluoropyridine
  • HY-W002734
    (3-Hydroxyphenyl)boronic acid

    3-Hydroxybenzeneboronic acid

    		 Drug Intermediate Endocrinology
    (3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .
    (3-Hydroxyphenyl)boronic acid
  • HY-W048492
    7-Iodo-7-deaza-2'-deoxyguanosine

    7-Deaza-7-Iodo-2'-deoxyguanosine

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a modified deoxyguanosine nucleoside. 7-Iodo-7-deaza-2'-deoxyguanosine is used in DNA synthesis and sequencing reactions .
    7-Iodo-7-deaza-2'-deoxyguanosine
  • HY-W034801
    Copper(II) acetylacetonate

    Cupric Acetylacetonate

    		 Biochemical Assay Reagents Others
    Copper(II) acetylacetonate (Cupric Acetylacetonate) is the homoleptic acetylacetonate complex of copper(II). Copper(II) acetylacetonate is used as a catalyst in various organic reactions, including oxidation, cross-coupling, and polymerization reactions. Copper(II) acetylacetonate is also a precursor for making metal-organic frameworks (MOF) and nanomaterials .
    Copper(II) acetylacetonate
  • HY-W583317
    sSPhos Pd G2

    		Biochemical Assay Reagents Endogenous Metabolite
    sSPhos Pd G2 is a palladium catalyst with excellent cross-coupling reaction activity. sSPhos Pd G2 exhibits efficient catalytic ability in the synthesis of organic molecules and compounds. sSPhos Pd G2 can effectively promote the formation of CC bonds, optimize reaction conditions and increase yields. sSPhos Pd G2 is also used in a variety of transformation reactions, helping researchers develop new materials and compounds.
    sSPhos Pd G2
  • HY-P3350
    LS-BF1

    		Bacterial Infection
    LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
    LS-BF1
  • HY-32928
    4-Cyanobenzeneboronic acid

    		Biochemical Assay Reagents Others
    4-Cyanobenzeneboronic acid is a Boronic acid derivative. 4-Cyanobenzeneboronic acid can be used in Suzuki-Miyaura cross-coupling reactions .
    4-Cyanobenzeneboronic acid
  • HY-W001987
    4,6-Dichloropyrimidin-5-amine

    		Biochemical Assay Reagents Others
    Organic ligands can be prepared through Suzuki cross-coupling reaction between 4,6-Dichloropyrimidin-5-amine and dimethyl(5-pinyl)isophthalate .
    4,6-Dichloropyrimidin-5-amine
  • HY-W002463
    3-Chlorophenyl boronic acid

    		Biochemical Assay Reagents Others
    3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .
    3-Chlorophenyl boronic acid
  • HY-W034606
    2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole

    CM-Phos

    		 Endogenous Metabolite Biochemical Assay Reagents
    2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole (CM-Phos) is an organic compound with catalytic activity. 2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole can be used as an efficient catalyst for cross-coupling reactions of various alcohols and olefins. 2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole shows important application potential in pharmaceutical and material science.
    2-[2-(Dicyclohexylphosphino)phenyl]-1-methyl-1H-indole
  • HY-W020985
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)

    Pd(DIPHOS)2

    		 Biochemical Assay Reagents Others
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.
    Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)
  • HY-120286
    K-13

    		Drug Intermediate Others
    K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.
    K-13
  • HY-119928
    Broparestrol

    		Biochemical Assay Reagents Cancer
    Broparestrol is a biologically active tetrasubstituted olefin can be achieved via palladium-catalyzed cross-coupling to form a C-C bond followed by bromination. Broparestrol inhibits mammary carcinogenesis in mouse model. Broparestrol can be used in dermatology and cancer research .
    Broparestrol
  • HY-W008658
    [1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate

    		Biochemical Assay Reagents Endogenous Metabolite
    [1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate is a highly efficient and selective transition metal catalyst that can catalyze a variety of reactions, including cross-coupling reactions and hydrogenation reactions. This compound is widely used in organic synthesis and helps to promote the development of new compounds and materials. Through its catalytic activity, [1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate offers the potential to optimize reaction conditions and improve yields.
    [1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate
  • HY-W582827
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)

    		Biochemical Assay Reagents Endogenous Metabolite
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)
  • HY-W075744
    SK-J002-1n

    		Biochemical Assay Reagents Endogenous Metabolite
    SK-J002-1n is a highly efficient catalyst with excellent cross-coupling reaction activity. SK-J002-1n is widely used in organic synthesis to construct complex molecular structures. The chiral properties of SK-J002-1n make it play an important role in the pharmaceutical industry and provide support for the synthesis of chiral compounds. SK-J002-1n can significantly improve the conversion efficiency and is an important component of transition metal catalysts.
    SK-J002-1n
  • HY-175553
    VEGFR-2-IN-72

    		VEGFR Apoptosis Cancer
    VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC50 of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC50s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC) .
    VEGFR-2-IN-72
  • HY-146489
    Anti-infective agent 3

    		Bacterial Parasite Infection
    Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .
    Anti-infective agent 3
  • HY-146488
    Anti-infective agent 2

    		Parasite Bacterial Infection
    Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .
    Anti-infective agent 2
  • HY-146487
    Anti-infective agent 1

    		Bacterial Parasite Infection
    Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .
    Anti-infective agent 1
  • HY-W543082
    P(o-tol)3 Pd G2 ChemBeads

    		Biochemical Assay Reagents Endogenous Metabolite Others
    P(o-tol)3 Pd G2 ChemBeads is a robust and air-stable catalyst featuring a bulky, electron-rich dialkylbiaryl phosphine, specifically designed for Pd-catalyzed cross-coupling reactions.
    P(o-tol)3 Pd G2 ChemBeads
  • HY-W543065
    CPhos Pd G2

    		Biochemical Assay Reagents Endogenous Metabolite
    CPhos Pd G2 is a highly efficient palladium catalyst with excellent cross-coupling reaction activity. CPhos Pd G2 is widely used in compound synthesis and material science, especially for the construction of complex organic molecules and the synthesis of bioactive compounds. CPhos Pd G2 is also favored for improving reaction selectivity and reducing the formation of by-products.
    CPhos Pd G2
  • HY-W075747
    SK-J014-1n

    		Endogenous Metabolite Biochemical Assay Reagents
    SK-J014-1n is a nickel catalyst with high cross-coupling activity. SK-J014-1n can effectively promote organic synthesis reactions and increase reaction rate and selectivity. SK-J014-1n exhibits good catalytic performance in the synthesis of complex organic molecules.
    SK-J014-1n
  • HY-W075745
    SK-J003-1n

    		Others
    SK-J003-1n is a nickel catalyst with excellent cross-coupling reaction activity. SK-J003-1n can be used as a ligand in organic synthesis to improve the selectivity and efficiency of the reaction. SK-J003-1n can effectively catalyze the coupling reaction between different substrates, highlighting its important role in compound development and material science.
    SK-J003-1n
  • HY-W714973
    Halauxifen-methyl

    		Herbicide Others
    Halauxifen-methyl is a 6-arylpicolinic acid herbicide. As a synthetic auxin, Halauxifen-methyl interferes with the normal growth and development of sensitive weeds by mimicking the action of endogenous plant auxins, causing malformation, uncontrolled growth and eventual death .
    Halauxifen-methyl

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