Search Result

Results for "

electric eel acetylcholinesterase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (3) Cholinesterase (ChE) (17) Drug Derivative (1) GSK-3 (2) Histamine Receptor (1) HSP (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (2) Reactive Oxygen Species (ROS) (1) Tau Protein (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Neurological Disease (18)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2860A

**Acetylcholinesterase, Electric eel**	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Electric eel is a cholinergic enzyme that is mainly found in neuromuscular junctions and cholinergic chemical synapses and is often used in biochemical research. Acetylcholinesterase, Electric eel can catalyze the decomposition or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetic acid and choline. The main function of Acetylcholinesterase, Electric eel is to terminate neuronal transmission and signal conduction between synapses to prevent ACh diffusion and activation of nearby receptors .

HY-110389

Pitofenone hydrochloride	Cholinesterase (ChE)	Neurological Disease
Pitofenone hydrochloride, a spasmolytic compound, inhibits the *acetylcholinesterase* (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-N10917

Xanthohumol I	Drug Derivative	Infection Cancer
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-105853

Pitofenone	Cholinesterase (ChE)	Neurological Disease
Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-105853S

Pitofenone-d4	Isotope-Labeled Compounds	Neurological Disease
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Neurological Disease
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-146035

AChE-IN-14	Cholinesterase (ChE) Histamine Receptor	Neurological Disease
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease .

HY-144790

AChE-IN-12	Amyloid-β Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC₅₀s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC₅₀ = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu ²⁺-induced Aβ_1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .

HY-183303

AChE-IN-116	Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease
AChE-IN-116 is a selective *acetylcholinesterase* (AChE) inhibitor with an electric eel AChE IC₅₀ of 1.60 μM and K_i of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease .

HY-181161

AChE-IN-107	Cholinesterase (ChE)	Neurological Disease
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.22 μM and a K_i of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .

HY-185346

AChE-IN-113	Cholinesterase (ChE)	Neurological Disease
AChE-IN-113 is a selective *acetylcholinesterase* inhibitor with a K_i value of 8.3 μM against electric eel acetylcholinesterase. AChE-IN-113 can be used for the research of Alzheimer's disease .

HY-N19855

Merulinic acid Geranicardic acid	Cholinesterase (ChE)	Neurological Disease
Merulinic acid (Geranicardic acid) is an *acetylcholinesterase* (AChE) inhibitor with an IC₅₀ >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease .

HY-185347

AChE-IN-114	Cholinesterase (ChE)	Neurological Disease
AChE-IN-114 is a selective AChE inhibitor and shows weak inhibitory activity for BChE. AChE-IN-114 can be used for the research of alzheimer’s disease .

HY-183760

AChE/BChE-IN-37	Cholinesterase (ChE) HSP GSK-3 Amyloid-β	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC₅₀ of 73.65 μM against electric eel-derived AChE and an IC₅₀ of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu ²⁺, Ca ²⁺, Mg ²⁺, Fe ²⁺ and Zn ²⁺. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ_1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases .

HY-181861

AChE/MAO-B-IN-9	Cholinesterase (ChE) Monoamine Oxidase Amyloid-β Tau Protein	Neurological Disease
AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC₅₀ of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease .

HY-N17394

Melineurine	Cholinesterase (ChE)	Neurological Disease
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease .

HY-182254

AChE/BChE-IN-35	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-35, Tacrine (HY-111338) derivative, is a brain-penetrant dual AChE/BChE inhibitor with an Electric Eel AChE IC₅₀ of 123.66 nM, human AChE IC₅₀ of 122.34 nM, and equine BChE IC₅₀ of 488.00 nM. AChE/BChE-IN-35 undergoes LAT1-mediated active transport across cell membranes. AChE/BChE-IN-35 exhibits enhanced brain exposure with slower brain tissue elimination. AChE/BChE-IN-35 can be used for the research of alzheimer's disease .

HY-181851

AChE-IN-109	Cholinesterase (ChE)	Neurological Disease
AChE-IN-109 is a potent mixed-type cholinesterase inhibitor with significantly stronger inhibitory activity against AChE than BChE. AChE-IN-109 has IC₅₀ values of 0.55 μM and 12.45 μM against AChE and BChE, respectively. AChE-IN-109 inhibits cholinesterases through a mixed-type mechanism, binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. AChE-IN-109 can be used for the study of Alzheimer’s disease (AD) .

HY-181811

PJ17	Cholinesterase (ChE) GSK-3	Neurological Disease
PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC₅₀ values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10917

Xanthohumol I	Structural Classification Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Drug Derivative
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-N7263

Galanthamine N-Oxide	Alkaloids other families Plants Source Classification	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-N19855

Merulinic acid Geranicardic acid	Structural Classification Microorganisms Antibiotics Source Classification	Cholinesterase (ChE)
Merulinic acid (Geranicardic acid) is an *acetylcholinesterase* (AChE) inhibitor with an IC₅₀ >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease .

HY-N17394

Melineurine	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Melicope pteleifolia (Champ. ex Benth.) Hartley Plants Source Classification	Cholinesterase (ChE)
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease .

Cat. No.	Product Name	Chemical Structure

HY-105853S

Pitofenone-d4
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

electric eel acetylcholinesterase

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products