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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
endothelin-1 (ET-1)
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "endothelin-1 (ET-1)" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: 5-Methyl THF; 5-MTHF
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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10
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10
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4
1
1 Cited Publications
Cat. No.: HY-P4159
CAS No.: 133972-52-8
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1
1 Cited Publications
Cat. No.: HY-P4159A
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1
1 Cited Publications
Cat. No.: HY-P700460
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EDN1; PPET1; endothelin 1; ARCND3; endothelin-1; HDLCQ7; ET1; QME; Preproendothelin-1
Species:
Human
Source:
E. coli
Cat. No.: HY-P2538
CAS No.: 120796-97-6
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Cat. No.: HY-113046S1
CAS No.: 212248-92-5
Synonyms: 5-Methyl THF-13C6; 5-MTHF-13C6
Synonyms: FI3542
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Ebrotidine (FI3542) is a competitive histamine H2 receptor (histamine H2 receptor) antagonist with gastric acid secretion inhibitory and gastric mucosal protective effects. Ebrotidine alleviates gastric mucosal injury and epithelial cell apoptosis induced by Indomethacin (HY-14397) and Helicobacter pylori LPS (HY-D1056), and accelerates chronic gastric ulcer healing by promoting rapid recovery of IL-4 and inhibiting TNF-α, endothelin-1 (ET-1) and NOS-2. Ebrotidine can be used in studies on gastric ulcer healing, NSAID-induced gastric mucosal injury, Helicobacter pylori-associated gastritis, and H2 receptor-mediated gastric mucosal protection mechanisms [1] .
Cat. No.: HY-P3733
CAS No.: 124932-61-2
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Cat. No.: HY-19890
CAS No.: 14748-94-8
Synonyms: Aminaftone; Aminaphthone
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Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.
Cat. No.: HY-133829
CAS No.: 75176-37-3
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Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure [1] .
Cat. No.: HY-15402
CAS No.: 210891-04-6
Synonyms: BMS 207940
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Edonentan (BMS 207940) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan can be used in research related to cardiovascular diseases [1].
Cat. No.: HY-P4159B
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Cat. No.: HY-10383
CAS No.: 198279-45-7
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J-104132 (L-753037) is a potent, orally active, selective and competitive ETA/ETB receptor antagonist with Ki of 0.034 nM for ETA and 0.104 nM for ETB receptors. J-104132 inhibits Endothelin-1 (ET-1) (HY-P71446)-induced signaling and vascular contractions in vitro. J-104132 alleviates hypertension, vascular remodeling, and diabetic endothelial dysfunction in vivo by dual ETA/ETB blockade. J-104132 can be used for research on diabetic vascular complications [1][3].
Cat. No.: HY-15402D
CAS No.: 264609-13-4
Synonyms: BMS 207940 hydrate
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Edonentan hydrate (BMS 207940 hydrate) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan hydrate blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan hydrate can be used in research related to cardiovascular diseases [1].
Cat. No.: HY-P2539
CAS No.: 120796-99-8
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Cat. No.: HY-N5170
CAS No.: 156223-06-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
