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fluconazole

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

1

Peptides

3

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0101
    Fluconazole
    20+ Cited Publications

    UK-49858

    		 Environmental Pollutants Antibiotic Fungal Bacterial Infection Cancer
    Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    Fluconazole
  • HY-B0277A
    Vidarabine phosphate

    ara-AMP; ara-A 5'-monophosphate

    		 EBV HSV Fungal DNA/RNA Synthesis Apoptosis Drug Intermediate Reactive Oxygen Species (ROS) Infection
    Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
    Vidarabine phosphate
  • HY-100666
    Fosfluconazole

    		Fungal Infection
    Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
    Fosfluconazole
  • HY-B0101S
    Fluconazole-d4

    UK-49858-d4

    		 Isotope-Labeled Compounds Fungal Antibiotic Infection
    Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    Fluconazole-d4
  • HY-B2153
    Tetraethylenepentamine pentahydrochloride

    		Cuproptosis Bacterial Infection
    Tetraethylenepentamine pentahydrochloride is an orally active copper chelator and copper mobilizer. Tetraethylenepentamine pentahydrochloride exhibits growth inhibitory and hypolipidemic properties. Tetraethylenepentamine pentahydrochloride significantly increases urinary copper excretion and reduces renal copper accumulation in copper overload models, but does not significantly alter hepatic copper levels. Tetraethylenepentamine pentahydrochloride exerts growth inhibitory effects on Candida albicans and Fluconazole (HY-B0101)-resistant strains, and can be widely used in studies related to Wilson's disease and Candida infections .
    Tetraethylenepentamine pentahydrochloride
  • HY-B0101R
    Fluconazole (Standard)

    UK-49858 (Standard)

    		 Reference Standards Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    Fluconazole (Standard)
  • HY-B0101B
    Fluconazole mesylate

    UK 49858 mesylate

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    Fluconazole mesylate
  • HY-B0101A
    Fluconazole hydrate

    UK 49858 hydrate

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    Fluconazole hydrate
  • HY-Z7155
    2-Desfluoro fluconazole

    		Fungal Infection
    2-Desfluoro fluconazole is an azole antifungal agent .
    2-Desfluoro fluconazole
  • HY-B0101S1
    Fluconazole-13C2,15N

    UK-49858-13C2,15N

    		 Isotope-Labeled Compounds Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole-13C2,15N (UK-49858-13C2,15N) is the 13C and 15N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    Fluconazole-13C2,15N
  • HY-150583
    Chitin synthase inhibitor 2

    		Fungal Inflammation/Immunology
    Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
    Chitin synthase inhibitor 2
  • HY-156090
    PK-10

    		Mitochondrial Metabolism Fungal Infection
    PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
    PK-10
  • HY-N10402
    Norbatzelladine L

    		Fungal Bacterial Parasite Infection Cancer
    Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC50 of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .
    Norbatzelladine L
  • HY-161822
    Antibacterial agent 230

    		Bacterial Infection
    Antibacterial agent 230 (compound 10) is an effective Antifungal agent. The MIC value of antibacterial agent 230 against fluconazole-resistant fungi is 2.0 ~ 16.0 μg/mL .
    Antibacterial agent 230
  • HY-147238
    Antifungal agent 35

    		Fungal Infection
    Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans .
    Antifungal agent 35
  • HY-155198
    Antifungal agent 72

    		Fungal Infection
    Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research .
    Antifungal agent 72
  • HY-136764
    CYP51-IN-14

    		Fungal Infection
    CYP51-IN-2 (compound 1n), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 1 μg/mL for Microsporum gypseum and Candida albicans .
    CYP51-IN-14
  • HY-136759
    CYP51-IN-9

    		Fungal Infection
    CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candida albicans .
    CYP51-IN-9
  • HY-136762
    CYP51-IN-12

    		Fungal Infection
    CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans .
    CYP51-IN-12
  • HY-136754
    CYP51-IN-4

    		Fungal Infection
    CYP51-IN-2 (compound 1d), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans .
    CYP51-IN-4
  • HY-113611
    SDZ89-485

    		Fungal Infection
    SDZ89-485 is an orally active triazole antifungal agent. The peak concentration of SDZ89-485 is lower, but it exhibits a stronger anti-sporofungus effect in the mouse model than Fluconazole (HY-B0101) with a higher peak concentration. SDZ89-485 can be used in studies on anti-sporofungus .
    SDZ89-485
  • HY-136763
    CYP51-IN-13

    		Fungal Infection
    CYP51-IN-2 (compound 1m), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively .
    CYP51-IN-13
  • HY-136758
    CYP51-IN-8

    		Fungal Infection
    CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candida albicans, respectively .
    CYP51-IN-8
  • HY-145873
    BI-10

    		Fungal Infection
    BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability .
    BI-10
  • HY-155279
    Antifungal agent 73

    		Fungal Infection
    Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains .
    Antifungal agent 73
  • HY-116686
    Inz-1

    		Cytochrome P450 Fungal Infection
    Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans .
    Inz-1
  • HY-141812
    Antifungal agent 12

    		Fungal Infection
    Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities.
    Antifungal agent 12
  • HY-132925
    Antifungal agent 16

    		Fungal Infection
    Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
    Antifungal agent 16
  • HY-100666R
    Fosfluconazole (Standard)

    		Reference Standards Fungal Infection
    Fosfluconazole (Standard) is the analytical standard of Fosfluconazole. This product is intended for research and analytical applications. Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
    Fosfluconazole (Standard)
  • HY-143406
    Antifungal agent 25

    		Fungal Infection
    Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo .
    Antifungal agent 25
  • HY-173490
    Antifungal agent 131

    		Fungal Infection
    Antifungal agent 131 (compound A20) is an antifungal compound with a minimum inhibitory concentration (MIC) of 64 μg/mL. Antifungal agent 131 demonstrates excellent antifungal potential when used in combination with Fluconazole (HY-B0101) .
    Antifungal agent 131
  • HY-P0068
    Aminocandin

    HMR 3270; IP960; NXL201

    		 Fungal Infection
    Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
    Aminocandin
  • HY-162271
    Antibacterial agent 187

    		Topoisomerase Fungal Infection
    Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL .
    Antibacterial agent 187
  • HY-173206
    Antifungal agent 128

    		Fungal Infection
    Antifungal agent 128 (Compound 3ja) is an antifungal agent. When used in combination with Fluconazole (HY-B0101), the MIC range against C. albicans strains is 0.5-4 μg/mL. Antifungal agent 128 can be used in the research of the anti-infection field .
    Antifungal agent 128
  • HY-146024
    Antifungal agent 28

    		Fungal Infection
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
    Antifungal agent 28
  • HY-153622
    Antifungal agent 57

    		Fungal Infection
    Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candida albicans strains with MIC values of 0.5-2 μg/mL .
    Antifungal agent 57
  • HY-153623
    Antifungal agent 58

    		Fungal Infection
    Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candida albicans strains with MIC values of 0.06-8 μg/mL .
    Antifungal agent 58
  • HY-153620
    Antifungal agent 55

    		Fungal Infection
    Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .
    Antifungal agent 55
  • HY-153619
    Antifungal agent 54

    		Fungal Infection
    Antifungal agent 54 (compound A05) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 54 is more effective than Miconazole (HY-B0454). Antifungal agent 54 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .
    Antifungal agent 54
  • HY-153621
    Antifungal agent 56

    		Fungal Infection
    Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candida albicans strains with MIC values of 0.03-0.25 μg/mL .
    Antifungal agent 56
  • HY-151410
    Chitin synthase inhibitor 5

    		Fungal Infection
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
    Chitin synthase inhibitor 5
  • HY-120432
    CaMdr1p-IN-1

    		Fungal ATP-binding cassette (ABC) transporters Infection
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM .
    CaMdr1p-IN-1
  • HY-155545
    Antifungal agent 60

    		Fungal Infection
    Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antifungal agent 60
  • HY-146464
    Antifungal agent 30

    		Fungal Infection
    Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
    Antifungal agent 30
  • HY-138074
    Milbemycin A4 oxime

    5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime

    		 Parasite Infection
    Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
    Milbemycin A4 oxime
  • HY-136752
    CYP51-IN-2

    		Fungal Infection
    CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively .
    CYP51-IN-2
  • HY-136757
    CYP51-IN-7

    		Fungal Infection
    CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively .
    CYP51-IN-7
  • HY-136756
    CYP51-IN-6

    		Fungal Infection
    CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candida albicans, respectively .
    CYP51-IN-6
  • HY-181404
    PA36-2

    		Fungal P-glycoprotein Infection
    PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis .
    PA36-2
  • HY-186076
    Hsp90-IN-47

    		HSP Fungal Infection Cancer
    Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer .
    Hsp90-IN-47

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