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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
fructose-1,6-bisphosphatase
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "fructose-1,6-bisphosphatase" in MCE Product Catalog:
7
7 Cited Publications
Cat. No.: HY-16307
CAS No.: 261365-11-1
Target:
Research Areas:
MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC50 value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance .
2
2 Cited Publications
Cat. No.: HY-P70275
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FBP1; Liver FBPase; Prev. FBP; Growth-Inhibiting Protein 17; fructose-1,6-bisphosphatase 1; fructose-bisphosphatase; D-fructose-1,6-Bisphosphate 1-Phosphohydrolase 1; fructose-bisphosphatase 1; FBPase 1
Species:
Human
Source:
HEK293
Target:
Target:
Research Areas:
FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase .
Target:
Cat. No.: HY-168103
CAS No.: 3102011-46-8
Target:
Research Areas:
FBPase-IN-3 (compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with an IC50 of 2.08 μM. FBPase-IN-3 exhibits potent inhibitory activity of gluconeogenesis .
Cat. No.: HY-168651
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Research Areas:
FBPase-IN-4 (Compound 11 n) is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor with a Ki value of 1.78 μM. FBPase-IN-4 can be used in type 2 diabetes research .
Cat. No.: HY-16309
CAS No.: 882757-24-6
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MB-07803 is an orally active second-generation prodrug inhibitor of fructose-1,6-bisphosphatase (FBP1). MB-07803 directly inhibits the rate-limiting enzyme in gluconeogenesis. MB-07803 regulates blood glucose and is used in studies of type 2 diabetes .
Cat. No.: HY-W197205
CAS No.: 380173-90-0
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Research Areas:
SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research .
Cat. No.: HY-W725496
CAS No.: 103213-47-4
Cat. No.: HY-182346
Target:
Research Areas:
FBPase-IN-7 is a fructose-1,6-bisphosphatase (FBPase) inhibitor with an IC50 of 0.75 μM. FBPase-IN-7 binds to a cryptic allosteric pocket of FBPase, induces conformational rearrangement of key residues, forms a hydrogen-bond network, and disrupts substrate catalysis. FBPase-IN-7 confirms cellular stabilizes HuFBPase in hepatic cells. FBPase-IN-7 has hypoglycemic activity. FBPase-IN-7 can be used for the research of type 2 diabetes .
Cat. No.: HY-113407B
CAS No.: 918149-30-1
Target:
Research Areas:
D-Fructose 6-phosphate disodium hydrate is an endogenous metabolite. D-Fructose 6-phosphate disodium hydrate can be obtained by hydrolysis of Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate disodium hydrate is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium hydrate can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate disodium hydrate can be used to study Lewy body dementia .
Cat. No.: HY-P81519
Synonyms: 6-bisphosphatase 1 antibody;
6-bisphosphate 1-phosphohydrolase 1 antibody;
D fructose 1 6 bisphosphate 1 phosphohydrolase 1 antibody;
D-fructose-1 antibody;
EC 3.1.3.11 antibody;
F16P1_HUMAN antibody;
FBP antibody;
FBP 1 antibody;
FBP1 antibody;
FBPase 1 antibody;
fructose 1 6 bisphosphatase 1 antibody;
fructose bisphosphatase 1 antibody;
fructose-1 antibody;
Growth inhibiting protein 17 antibody;
Liver fructose bisphosphatase antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
