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Uroguanylin (human) is a natural ligand for the GuanylylCyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer .
Cenderitide is a potent agonist of particulate guanylylcyclasereceptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
MCUF-651 is an orally active guanylylcyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy .
Uroguanylin (human) is a natural ligand for the GuanylylCyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer .
Cenderitide is a potent agonist of particulate guanylylcyclasereceptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .
GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is the recombinant rat-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-His, C-Myc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is 407 a.a., with molecular weight of ~51.4 kDa.
GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Cynomolgus (HEK293, His) is 407 a.a., with molecular weight of 60-75 kDa.
GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP. As a receptor for E. coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling. GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is the recombinant canine-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Canine (HEK293, His) is 410 a.a., with molecular weight of 75-80 kDa.
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is 407 a.a., with molecular weight of 85-115 kDa.
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, His-Avi) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, His-Avi) is 407 a.a., with molecular weight of 70-80 kDa.
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-10*His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) is 407 a.a., with molecular weight of 49.6 kDa.
GUCY2C, a vital guanylyl cyclase, catalyzes the synthesis of cyclic cGMP from GTP. GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His-Avi) is 414 a.a., with molecular weight of 70-120 kDa.
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (Biotinylated, HEK293, His-Avi) is 407 a.a., with molecular weight of 55-65 kDa.
GUCY2C, a vital guanylyl cyclase, catalyzes the synthesis of cyclic cGMP from GTP. GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, N-His, C-Myc) is the recombinant mouse-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, N-His, C-Myc) is 414 a.a., with molecular weight of 52.1 kDa.
GUCY2C, a vital guanylyl cyclase, catalyzes the synthesis of cyclic cGMP from GTP. GUCY2C/Guanylyl cyclase C Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Mouse (Biotinylated, HEK293, His-Avi) is 414 a.a., with molecular weight of 70-100 kDa.
GUCY2C, a vital guanylyl cyclase, catalyzes the synthesis of cyclic cGMP from GTP. GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His) is the recombinant mouse-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293, with C-6*His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, His) is 414 a.a., with molecular weight (glycosylation form) of 66-120 kDa (SDS-PAGE).
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. FITC-labeled GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-labeled GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-labeled GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, Fc) is 407 a.a., with molecular weight of 90-115 kDa.
GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. FITC-labeled GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with His labeled tag. The total length of FITC-labeled GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, His) is 407 a.a., with molecular weight of 60-90 kDa.
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