Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
human breast adenocarcinoma
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "human breast adenocarcinoma" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: ODN 2006; PF-3512676; CpG 7909; ODN 7909
Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC50 of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6, and mediates downstream signaling pathways via IRAK4, IRF5, IRF7. Agatolimod induces Th1-type innate and adaptive immune responses, activates various immune cells and promotes antigen presentation, regulates antibody levels and immune cell infiltration, upregulates the secretion of multiple cytokines, induces apoptosis and cell cycle arrest, enhances cytotoxicity, and clears intracellular Salmonella. Agatolimod is applicable to research on COVID-19, breast cancer, lung adenocarcinoma, HPV-related tumors, melanoma, and salmonellosis .
1
1
1 Cited Publications
Cat. No.: HY-147785
CAS No.: 2543624-91-3
Target:
Research Areas:
Pim-1 kinase inhibitor 2 is a PIM-1 kinase inhibitor with a human IC50 of 0.63 μM. Pim-1 kinase inhibitor 2 exhibits high selectivity for cancer cells over normal cells. Pim-1 kinase inhibitor 2 induces apoptosis, increases active caspase-3 levels, upregulates BAX, downregulates Bcl-2, and elevates the Bax/Bcl-2 ratio. Pim-1 kinase inhibitor 2 suppresses cancer cell proliferation and induces cell cycle arrest. Pim-1 kinase inhibitor 2 can be used for the research of prostate carcinoma, hepatocellular carcinoma, and breast adenocarcinoma .
Cat. No.: HY-P5098
CAS No.: 250612-47-6
Target:
Research Areas:
Cat. No.: HY-165245
CAS No.: 625403-59-0
Target:
Research Areas:
SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo .
Cat. No.: HY-W014989
CAS No.: 20408-97-3
Cat. No.: HY-118054
CAS No.: 1185410-60-9
Target:
Research Areas:
LRH-1 Inhibitor-3 is a small molecule that inhibits LRH-1 transcriptional activity, thereby decreasing the expression of target genes associated with cell growth and proliferation. LRH-1 Inhibitor-3 has shown potential in reducing cancer cell proliferation in human pancreatic, colon, and breast adenocarcinoma cell lines. LRH-1 Inhibitor-3 serves as a molecular probe for investigating the role of LRH-1 in various malignancies.
Cat. No.: HY-N10777
CAS No.: 105062-36-0
Target:
Cat. No.: HY-151570
Target:
Research Areas:
Anticancer agent 87 is a spirooxindole-furan derivative with anticancer activity. Anticancer agent 87 can be used for the research of breast adenocarcinoma and human liver cancer .
Cat. No.: HY-162721
Target:
Research Areas:
Anticancer agent 242 (7) possesses anticancer activity in A2780 (IC50 = 0.24 μM, ovarian adenocarcinoma), A2780cis (IC50 = 0.45 μM, resistant derivative of A2780), CCD18Co (IC50 = 0.59 μM, non-malignant human fibroblasts), A549 (IC50 = 0.32 μM, lung carcinoma), HT29 (IC50 = 0.26 μM, colorectal adenocarcinoma), and MCF7 (IC50 = 0.55 μM, breast adenocarcinoma) .
Cat. No.: HY-N4227
CAS No.: 76758-18-4
Target:
Cat. No.: HY-123664
CAS No.: 68307-81-3
Synonyms: LY133314
Target:
Research Areas:
Trioxifene mesylate (LY133314) is an orally active and selective estrogen receptor (ER) modulator with human ERα IC50 of 203.49 nM and Ki of 20.84 nM. Trioxifene mesylate binds estradiol receptors, inhibits ERα-mediated gene expression, reduces circulating gonadotrophin levels. Trioxifene mesylate can be used for the research of advanced breast cancer and androgen-independent, metastatic prostatic adenocarcinoma .
Cat. No.: HY-N18083
CAS No.: 123914-43-2
Category:
Zingiberaceae Extract Terpenoids Sesquiterpenes Curcuma aromatica Salisb. cv. Wenyujin Plants
Target:
Cat. No.: HY-151572
Target:
Research Areas:
Anticancer agent 88 is a spirooxindole-furan derivative with anticancer activity. Anticancer agent 88 can be used for the research of breast adenocarcinoma and human liver cancer .
Cat. No.: HY-135529
CAS No.: 63619-84-1
Synonyms: LY133314 free base
Target:
Research Areas:
Trioxifene (LY133314 free base) is an orally active and selective estrogen receptor (ER) modulator with human ERα IC50 of 203.49 nM and Ki of 20.84 nM. Trioxifene binds estradiol receptors, inhibits ERα-mediated gene expression, reduces circulating gonadotrophin levels. Trioxifene can be used for the research of advanced breast cancer and androgen-independent, metastatic prostatic adenocarcinoma .
Cat. No.: HY-106289
CAS No.: 105026-50-4
Target:
Research Areas:
Antibiotic MX 2 is an orally active antibiotic that can cross the blood-brain barrier. Antibiotic MX 2 inhibits the growth of drug-sensitive and multidrug-resistant tumor cells, prolongs the survival of tumor-bearing mice, induces single-strand and double-strand DNA breaks, suppresses colony formation of fresh human-derived tumor cells, and overcomes multidrug resistance mediated by P-glycoprotein. Antibiotic MX 2 can be used in research related to L1210 leukemia, Lewis lung cancer, colon adenocarcinoma type 26 and type 38, gastric adenocarcinoma, non-small cell lung cancer, mammary adenocarcinoma, drug-resistant P388 leukemia, renal cancer, melanoma, ovarian cancer, breast cancer, small cell lung cancer, and colorectal cancer .
Cat. No.: HY-181166
EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC50 of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia .
Cat. No.: HY-P992347
Target:
Research Areas:
Cat. No.: HY-101145
CAS No.: 1001478-90-5
Target:
Research Areas:
CK37 is a competitive choline kinase-α inhibitor. CK37 inhibits purified recombinant human choline kinase-α activity. CK37 suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization. CK37 diminishs activating phosphorylations of ERK. CK37 exhibits anticancer activity against cervical cancer, melanoma, Lewis lung carcinoma, lung adenocarcinoma, breast cancer, and leukemia .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
