52 Results for "

human colon adenocarcinoma

" in MedChemExpress (MCE) Product Catalog:
Products (52)

52 Results for "human colon adenocarcinoma" in MCE Product Catalog:

13
13 Publications Verification
Cat. No.: HY-17411
CAS No.: 1180-71-8
Synonyms: Limonoic acid 3,19:16,17 dilactone
Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin has antiviral and antitumor activities .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N6065
CAS No.: 73069-27-9
Synonyms: (+)-Praeruptorin A
Praeruptorin A ((+)-Praeruptorin A) is an orally active isomer of (±)-Praeruptorin A (HY-N0081). Praeruptorin A also acts as a Calcium channel blocker. Praeruptorin A can be isolated from Peucedanum. Praeruptorin A serves as a substrate for CYP3A4. Praeruptorin A downregulates NMDA receptors containing GluN2B and inhibits neuronal Apoptosis. Praeruptorin A mediates vasodilation, inhibits vascular hypertrophy and reduces blood pressure. Praeruptorin A can be used in research related to neurological diseases, myocardial ischemia, heart failure, exertional angina, renovascular hypertension and spontaneous hypertension .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-126350
CAS No.: 1036969-20-6
Purity:  99.14%
Research Areas:  

Cancer

CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W854385A
Synonyms: SLeA sodium
Research Areas:  

Cancer

Sialyl Lewis A (SLeA) sodium is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A sodium promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A sodium shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A sodium can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .
loading...
    loading...
Cat. No.: HY-N2571
CAS No.: 476-69-7
Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC50 of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC50 of 0.51 μM for MOR, and a Ki of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .
loading...
    loading...
Cat. No.: HY-113319
CAS No.: 53188-23-1
Purity:  99.76%
β-D-Fructose is a monosaccharide. Derivatives synthesized using β-D-Fructose as the sugar backbone exhibit potent and selective antiproliferative activity against breast cancer MCF-7 cells .
loading...
    loading...
Cat. No.: HY-W002016
CAS No.: 253-52-1
Phthalazine is a chemical scaffold. Phthalazine derivatives act as VEGFR-2 inhibitors, PARP-1 inhibitors, and anticancer agents. The complex of phthalazine with silver exhibits broad-spectrum antibacterial and antifungal activities against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa PAO1, and Candida albicans. Phthalazine derivatives possess potent vasodilatory activity. Phthalazine can be used in research related to colon adenocarcinoma, breast cancer, hypertension, diabetes, and microbial infections .
loading...
    loading...
Cat. No.: HY-P99884
CAS No.: 2206792-50-7
Synonyms: PF-06801591

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Sasanlimab is a humanized IgG4 isotype anti-PD-1 antibody. Sasanlimab blocks PD-1 interaction with PD-L1/PD-L2, reverses PD-1-mediated inhibitory T-cell signaling, augments T-cell proliferation and cytokine production. Sasanlimab inhibits colon adenocarcinoma tumor growth, and accelerates graft-versus-host disease incidence via enhanced T-cell activity. Sasanlimab can be used for the research of cancer, such as bladder cancer and colon adenocarcinoma .
loading...
    loading...
Cat. No.: HY-126779
CAS No.: 549-06-4
Purity:  98.5%
Stictic acid is a Depsidone. Stictic acid is found in the edible lichens Lobaria pindarensis and Lobaria pulmonaria. Stictic acid inhibits LPS/Aβ42-induced mRNA expression of iNOS, IL-1β, TNF-α, and IL-6, and decreases LPS-induced COX-2 protein expression. Stictic acid inhibits 42 fibril formation and aggregation. Stictic acid scavenges superoxide anions. Stictic acid exhibits anticancer activity against colon adenocarcinoma. Stictic acid is used in research on Alzheimer's disease and colon adenocarcinoma .
loading...
    loading...
Cat. No.: HY-E70127
CAS No.: 37312-62-2
Synonyms: Brasan; Dasen
Serratiopeptidase (Brasan; Dasen) is an orally active zinc-containing metalloprotease belonging to the serralysin family. Serratiopeptidase reduces the release of inflammatory mediators such as prostaglandins, thromboxanes and interleukins by inhibiting COX, thereby relieving pain, swelling and redness. Serratiopeptidase exhibits antibiofilm, mucolytic and wound-healing activities. As a serine protease, Serratiopeptidase has the ability to dissolve blood clots, fibrin and atherosclerotic plaques. Serratiopeptidase degrades amyloid fibrils and has potential anti-Alzheimer's effects. Serratiopeptidase shows cytotoxicity against colon cancer cells .
loading...
    loading...
Cat. No.: HY-N10423
CAS No.: 18423-69-3
Synonyms: (-)-Cubebin
Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .
loading...
    loading...
Cat. No.: HY-126400
CAS No.: 1406-66-2
Purity:  98.6%
Tocopherols are orally effective antioxidants and ferroptosis inhibitors. Tocopherols scavenge ROS/RNS, alleviate DNA damage, downregulate cyclin D1/c-Myc/TFF/pS2/PGR in an ER-dependent manner, and inhibit ferroptosis mediated by lipid peroxidation. Tocopherols block the occurrence of ferroptosis in Gpx4-knockout Pfa1 cells, with an EC50 value of 1.0-2.3 μM. Tocopherols inhibit tumor growth. Tocopherols can be used in studies related to estrogen-mediated ER + breast cancer, oxidative stress-induced carcinogenesis, and ferroptosis regulation .
loading...
    loading...
Cat. No.: HY-173178
CAS No.: 925419-55-2
Research Areas:  

Cancer

LNS8801 is an orally active GPER activator with tumor suppressor activity. LNS8801 mediates suppression of cancer via GPER activation, with activity dependent on GPER expression. LNS8801 suppresses cancer growth in preclinical models. LNS8801 can be used for the research of cancer (including melanoma, pancreatic ductal adenocarcinoma, non-small cell lung cancer, leukemias, colon carcinomas) .
loading...
    loading...
Cat. No.: HY-P991214
CAS No.: 339986-90-2
Synonyms: EMD 273066; huKS-IL2

Target:  

Interleukin Related

Research Areas:  

Cancer

Tucotuzumab celmoleukin (EMD 273066) is an immunocytokine. Tucotuzumab celmoleukin consists of the following components: an IgG1 monoclonal antibody targeting human EpCAM antigen, and two molecules of IL2. Tucotuzumab celmoleukin binds to EpCAM. Tucotuzumab celmoleukin exerts anti-tumor effects on colon adenocarcinoma in synergy with radiofrequency ablation. Tucotuzumab celmoleukin can be used in research related to colon adenocarcinoma and colon cancer .
loading...
    loading...
Cat. No.: HY-17411R
CAS No.: 1180-71-8
Synonyms: Limonoic acid 3,19:16,17 dilactone (Standard)
Limonin (Standard) is the analytical standard of Limonin. This product is intended for research and analytical applications. Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin has antiviral and antitumor activities .
loading...
    loading...
Cat. No.: HY-N8420
CAS No.: 21796-15-6
Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .
loading...
    loading...
Cat. No.: HY-W585827
CAS No.: 497-04-1
Synonyms: 2-MCPD
Target:  

Drug Derivative

Research Areas:  

Others

2-Chloro-1,3-propanediol (2-MCPD) is a pharmaceutical intermediate. 2-Chloro-1,3-propanediol is a common glycerol-derived chemical intermediate and also a food processing contaminant. 2-Chloro-1,3-propanediol can cross the intestinal barrier model via paracellular diffusion. 2-Chloro-1,3-propanediol induces renal and testicular toxicity in animal models. 2-Chloro-1,3-propanediol can be used in research related to organic synthesis .
loading...
    loading...
Cat. No.: HY-105314
CAS No.: 477844-47-6
Target:  

Others

Research Areas:  

Cancer

LY-33169 is an antitumor agent. LY-33169 had selective cytotoxicity against Colon Adenocarcinoma-38, Human Colon-116, Human Prostate LNCaP, and Human Breast WSU-Br-1 cells .
loading...
    loading...
Cat. No.: HY-P99691
CAS No.: 250242-54-7
Synonyms: IMMU-MN3
Lemalesomab (IMMU-MN3) is a Fab' fragment of a murine anti-granulocyte monoclonal antibody targeting NCA-90 (CEACAM6). Lemalesomab binds strongly to NCA-90 on the surface of granulocytes, cross-reacts with epitopes of other CEA family members, and blocks the binding between human colon adenocarcinoma cells and CEA. When labeled with 99mTc, Lemalesomab can be used for radionuclide imaging of soft tissue infections and osteomyelitis .
loading...
    loading...