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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
human melanoma cell lines
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "human melanoma cell lines" in MCE Product Catalog:
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2 Cited Publications
Research Areas:
EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .
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Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
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1 Cited Publications
Cat. No.: HY-N2466A
CAS No.: 1566590-77-9
Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
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Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Category:
Cardiovascular Disease Triterpenes Terpenoids Plants Disease Research Fields Caryophyllaceae Gypsophila perfoliata Linn.
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Cat. No.: HY-N10423
CAS No.: 18423-69-3
Synonyms: (-)-Cubebin
Cat. No.: HY-100948B
CAS No.: 2438679-30-0
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines.
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MDM4-targeting ASO (sodium)
Cat. No.: HY-158830
Cat. No.: HY-N12834
CAS No.: 1887196-18-0
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Cat. No.: HY-W854934
CAS No.: 114231-14-0
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IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM). IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma .
Cat. No.: HY-121382R
CAS No.: 639-14-5
Cat. No.: HY-117991
CAS No.: 1804982-31-7
DW10075 is a highly selective and orally active VEGFR inhibitor targeting the VEGF/VEGFR pathway. DW10075 selectively inhibits VEGFR-1, VEGFR-2, and VEGFR-3, but has no effect on FGFR and PDGFR. DW10075 inhibits VEGF-induced HUVEC proliferation, migration, and tube formation. And DW10075 inhibits angiogenesis in both the rat aortic ring model and the chick chorionic membrane model. DW10075 also exhibits antiproliferative activity against human cancer cell lines, with IC50s of 2.2 μM and 22.2 μM against U87-MG human glioblastoma cells and A375 melanoma cells, respectively. In the nude mouse U87-MG xenograft tumor model, DW10075 (po) significantly inhibits tumor growth and reduces the expression of CD31 and Ki67 in tumor tissues.
Cat. No.: HY-124130
CAS No.: 2170836-81-2
MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein .
Cat. No.: HY-100948R
CAS No.: 1861449-70-8
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ATM-3507 (Standard) is the analytical standard of ATM-3507 (HY-100948). This product is intended for research and analytical applications. ATM-3507 is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines.
Cat. No.: HY-D3140
Cat. No.: HY-189236
CAS No.: 3111620-80-2
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XJ-4-85 is a covalent activator and precursor compound targeting PFKL (EC50=56 μM in human PFKL). XJ-4-85 activates glycolysis, increases FBP production and glycolytic flux, and enhances LPS-stimulated proinflammatory cytokine release in macrophages. XJ-4-85 causes long-chain acylcarnitine accumulation, metabolic stress, and cytotoxicity through the release of the active payload XJ-4-119 targeting CPT2. XJ-4-85 exhibits broad and selective cytotoxicity across multiple cancer cell lines and is useful for melanoma research .
Cat. No.: HY-123859
CAS No.: 1454584-91-8
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SR-2890 is a highly selective, ATP-competitive inhibitor of casein kinase CK1δ and CK1ε, with IC50 values of 4 nM and 44 nM, respectively, and a Ki of 14 nM for CK1δ. SR-2890 exhibits antiproliferative effects. SR-2890 blocks the serine/threonine kinase activity of CK1δ and weakly inhibits a few off-target kinases such as FLT3, CDK4. SR-2890 has an oral bioavailability of 10% and a blood-brain barrier penetration rate of <1%. SR-2890 demonstrates stable in vitro metabolism and favorable in vivo pharmacokinetic properties, effectively inhibiting the growth of human A375 melanoma cells. SR-2890 can be used in melanoma research and is also a useful compound for studying CK1δ/ε-related diseases such as Alzheimer's disease .
Cat. No.: HY-D3432
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Rhodamine B ethyl ester is a hydrophilic cationic derivative of Rhodamine B (HY-Y0016), belonging to non-selective cytotoxic agents and transporters. Rhodamine B ethyl ester exhibits broad-spectrum in vitro cytotoxicity and exerts cytotoxic effects on human tumor cells. Rhodamine B ethyl ester binds effectively to lipid membranes, undergoes voltage-dependent transport across planar bilayer phosphatidylcholine membranes, and its transport can be determined by current relaxation after voltage jump. Rhodamine B ethyl ester can be used in research related to cancers such as epithelioid melanoma and colorectal adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
