Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
314 Results for "
il17
" in MedChemExpress (MCE) Product Catalog:
Products (314)
314 Results for "il17" in MCE Product Catalog:
24
24 Publications Verification
Research Areas:
SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .
12
12
12 Cited Publications
Cat. No.: HY-P9927A
CAS No.: 1229022-83-6
Target:
Research Areas:
12
Target:
Research Areas:
7
7 Cited Publications
Target:
Research Areas:
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
6
5
5
Category:
Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides
Target:
4
4 Cited Publications
Synonyms: il-17A inhibitor 1
Target:
Research Areas:
LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .
4
4 Cited Publications
Cat. No.: HY-19770
CAS No.: 1474110-21-8
Target:
Research Areas:
GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding .
3
3 Cited Publications
Target:
Research Areas:
IL-17A antagonist 1 (Compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM .
3
3 Cited Publications
Cat. No.: HY-P79326
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il17a; interleukin 17A; il17; il-17; CTLA-8; il-17A; interleukin-17A; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17
3
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P700194AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTLA8; CTLA-8; il-17; Interleukin-17A; il17A
3
3 Cited Publications
Target:
Research Areas:
SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1 .
3
3 Cited Publications
Target:
Research Areas:
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
3
3 Cited Publications
Target:
Research Areas:
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
3
3 Cited Publications
Synonyms: Hyperforin DCHA
Target:
2
2 Cited Publications
Target:
Research Areas:
IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .
2
2 Cited Publications
Cat. No.: HY-P71963
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CANDF5; CD217; CD217 antigen; CDw217; CTLA8; Hil 17R; hil17R; I17RA_HUMAN; il 17 receptor A; il 17 receptor; il 17RA; il-17 receptor A; il-17RA; il17; il17A receptor; il17R; il17RA; IMD51; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
