Search Result

Results for "

lysine demethylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Histone Demethylase (89) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (16) Dopamine Receptor (3) Drug Derivative (1) E1/E2/E3 Enzyme (1) Fat Mass and Obesity-associated Protein (FTO) (1) HDAC (4) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (3) Ligands for Target Protein for PROTAC (2) Monoamine Oxidase (9) PD-1/PD-L1 (1) PROTACs (2) Reference Standards (9) TGF-beta/Smad (1) TNF Receptor (1)
By Research Areas:	Cancer (85) Cardiovascular Disease (5) Inflammation/Immunology (6) Neurological Disease (9)

By Targets:

Histone Demethylase (89)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (16)

Dopamine Receptor (3)

Drug Derivative (1)

E1/E2/E3 Enzyme (1)

Fat Mass and Obesity-associated Protein (FTO) (1)

HDAC (4)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Methyltransferase (3)

Ligands for Target Protein for PROTAC (2)

Monoamine Oxidase (9)

PD-1/PD-L1 (1)

PROTACs (2)

Reference Standards (9)

TGF-beta/Smad (1)

TNF Receptor (1)

By Research Areas:

Cancer (85)

Cardiovascular Disease (5)

Inflammation/Immunology (6)

Neurological Disease (9)

Inhibitors & Agonists

Screening Libraries

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Histone Demethylase WNK Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17447A

Tranylcypromine hydrochloride 5+ Cited Publications SKF 385 hydrochloride	Monoamine Oxidase Ligands for Target Protein for PROTAC Histone Demethylase	Neurological Disease
Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC₅₀s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression .

HY-112623

Vafidemstat 2 Publications Verification ORY-2001	Histone Demethylase Monoamine Oxidase	Neurological Disease
Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor .

HY-B1496

Tranylcypromine hemisulfate 5+ Cited Publications SKF 385 hemisulfate	Monoamine Oxidase Histone Demethylase	Neurological Disease Cancer
Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects .

HY-12635

SP2509 10+ Cited Publications	Histone Demethylase Apoptosis	Cancer
SP2509 is a potent and selective antagonist of lysine specific demethylase 1 (LSD1) with an IC₅₀ of 13 nM .

HY-12782T

Iadademstat dihydrochloride 5+ Cited Publications ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride	Histone Demethylase	Cancer
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

HY-18632

GSK2879552 Maximum Cited Publications 19 Publications Verification	Histone Demethylase	Cancer
GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity .

HY-129388B

Pulrodemstat benzenesulfonate 4 Publications Verification CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ of 0.25 nM. Pulrodemstat benzenesulfonate is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-100546A

GSK-LSD1 dihydrochloride 10+ Cited Publications	Histone Demethylase Monoamine Oxidase	Cancer
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 16 nM.

HY-B0735A

Fenoldopam mesylate 4 Publications Verification Fenoldopam methanesulfonate; SKF-82526 mesylate	Dopamine Receptor Apoptosis	Cardiovascular Disease Cancer
Fenoldopam mesylate (SKF-82526) is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis .

HY-16012A

Domatinostat 3 Publications Verification 4SC-202 free base	HDAC Apoptosis	Cancer
Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC₅₀ of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).

HY-109169

Bomedemstat 3 Publications Verification IMG-7289	Histone Demethylase Apoptosis	Cancer
Bomedemstat (IMG-7289) is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis .

HY-111048

Corin 5 Publications Verification	Histone Demethylase HDAC	Cancer
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a K_i(inact) of 110 nM for LSD1 and an IC₅₀ of 147 nM for HDAC1.

HY-18632A

GSK2879552 dihydrochloride Maximum Cited Publications 19 Publications Verification	Histone Demethylase	Cancer
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity .

HY-16012

Domatinostat tosylate 3 Publications Verification 4SC-202	HDAC Apoptosis	Cancer
Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC₅₀ of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).

HY-19612A

DDP-38003 dihydrochloride 1 Publications Verification	Histone Demethylase	Cancer
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM .

HY-102047B

KDOAM-25 citrate 5+ Cited Publications	Histone Demethylase	Cancer
KDOAM-25 citrate is a potent and highly selective *histone lysine* demethylases 5 (KDM5) inhibitor with IC₅₀**s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-12315

N-Oxalylglycine N-Oxaloglycine	Histone Demethylase HIF/HIF Prolyl-Hydroxylase	Cancer
N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC₅₀ of 2.1 μM and 5.6 μM, respectively .

HY-100014

KDM5A-IN-1 4 Publications Verification	Histone Demethylase	Cancer
KDM5A-IN-1 is a potent, orally bioavailable pan-*histone lysine* demethylases 5 (KDM5) inhibitor with IC₅₀s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC₅₀ value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B** enzymes (1A, 2B, 3B, 4C, 6A, 7B) .

HY-108706

KDM2A/7A-IN-1	Histone Demethylase	Cancer
KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of *histone lysine* demethylases KDM2A/7A, with an IC₅₀** of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases .

HY-122635A

T-448	Histone Demethylase	Neurological Disease
T-448 is a specific, orally active, CNS-penetrant and irreversible inhibitor of **lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC₅₀** of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons .

HY-101928

KDM4D-IN-1 2 Publications Verification	Histone Demethylase	Cancer
KDM4D-IN-1 is a new *histone lysine* demethylase 4D (KDM4D) inhibitor with an IC₅₀** value of 0.41±0.03 μM.

HY-110130

RN-1 dihydrochloride	Histone Demethylase	Cardiovascular Disease Cancer
RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively .

HY-109169A

Bomedemstat ditosylate 3 Publications Verification IMG-7289 ditosylate	Histone Demethylase Apoptosis	Cancer
Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis .

HY-141677

INCB059872	Histone Demethylase	Cancer
INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 can be used for the research of myeloid leukemia .

HY-100764

YUKA1 1 Publications Verification	Histone Demethylase	Cancer
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC₅₀ of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC₅₀ = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers .

HY-103085

T-3775440 hydrochloride 3 Publications Verification	Histone Demethylase	Cancer
T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC₅₀ value of 2.1 nM.

HY-110277

S2101	Histone Demethylase	Cancer
S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 0.99 μM, K_i of 0.61 μM and K_inact/K_i of 4560 M/s .

HY-109169B

Bomedemstat hydrochloride 3 Publications Verification IMG-7289 hydrochloride	Histone Demethylase Apoptosis	Cancer
Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis .

HY-156202

Geranylgeranoic acid	Histone Demethylase PD-1/PD-L1 Apoptosis	Cancer
Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis .

HY-158432

GT-653	Histone Demethylase PROTACs	Cancer
GT-653 is a PROTAC degrader for lysine-specific demethylase 5B (KDM5B). GT-653 degrades 68.35% KDM5B at 10 μM in a ubiquitin proteasome-dependent manner, upregulates H3K4me3 levels, and activates the type-I interferon signaling pathway in prostate cancer cells 22RV1. (Pink: KDM5B ligand (HY-158433); Black: Linker (HY-W004896); Blue: E3 ligase ligand (HY-103596))

HY-149091

KDM5B-IN-4	Histone Demethylase	Cancer
KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC₅₀ of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs .

HY-112308

NCGC00247743 2 Publications Verification	Histone Demethylase	Cancer
NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.

HY-129388A

Pulrodemstat 4 Publications Verification CC-90011; LSD1-IN-7	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ of 0.25 nM. Pulrodemstat is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-141677A

INCB059872 dihydrochloride	Histone Demethylase	Cancer
INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 dihydrochloride can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 dihydrochloride can be used for the research of myeloid leukemia .

HY-102047

KDOAM-25	Histone Demethylase	Cancer
KDOAM-25 is a potent and highly selective *histone lysine* demethylases 5 (KDM5) inhibitor with IC₅₀**s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-109169C

Bomedemstat dihydrochloride 3 Publications Verification IMG-7289 dihydrochloride	Histone Demethylase Apoptosis	Cancer
Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis .

HY-117226A

GSK 690 Hydrochloride 3 Publications Verification	Histone Demethylase	Others
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a K_d value of 9 nM and a biochemical IC₅₀ of 37 nM.

HY-148807B

(S)-Zavondemstat (S)-QC8222 free base; (S)-TACH 101 free base	Histone Demethylase	Others
(S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of *histone lysine* demethylase 4D (KDM4D)** with antineoplastic activity ^{[1] ^.}

HY-19612B

DDP-38003 trihydrochloride	Histone Demethylase	Cancer
DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM.

HY-100859

LSD1-IN-5	Histone Demethylase	Cancer
LSD1-IN-5 (Compound 4e) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC₅₀ of 121 nM. LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1 .

HY-170668

DDO-02267	Anaplastic lymphoma kinase (ALK) Fat Mass and Obesity-associated Protein (FTO)	Cancer
DDO-02267 is a selective and lysine-targeting covalent inhibitor of ALKBH5, with an IC₅₀ value of 0.49 μM. DDO-02267 increases N ⁶-methyladenosine (m ⁶A) levels and targets the ALKBH5-AXL signaling axis. DDO-02267 can serve as a probe for investigating the biological function of mRNA demethylase .

HY-150619

KDM4-IN-4	Histone Demethylase	Cancer
KDM4-IN-4 (compound 47) is a potent *histone lysine* demethylase 4 (KDM4)** inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC₅₀ value of 105 μM. KDM4-IN-4 can be used for researching anticancer .

HY-136522

S2116	Histone Demethylase Apoptosis	Cancer
S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice .

HY-77732

Ticagrelor acetonide Isopropylidene ticagrelor	Drug Derivative	Cancer
Ticagrelor acetonide (Isopropylidene ticagrelor) (Compound 7) is a drug intermediate that can be used for the synthesis of lysine-specific demethylase (LSD1) inhibitors .

HY-151194

LSD1/2-IN-4	Histone Demethylase	Cancer
LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with K_i values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL) .

HY-129388C

Pulrodemstat hydrochloride CC-90011 hydrochloride; LSD1-IN-7 hydrochloride	Histone Demethylase	Inflammation/Immunology Cancer
Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC₅₀ value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity .

HY-12645

NCL1	Histone Demethylase	Cancer
NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC₅₀ values of 2.5 and 26 μM for LSD1 and LSD2, respectively .

HY-100860

LSD1-IN-6	Histone Demethylase	Cancer
LSD1-IN-6 (Compound 4m) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC₅₀ of 123 nM. LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1 .

HY-102047A

KDOAM-25 trihydrochloride	Histone Demethylase	Cancer
KDOAM-25 trihydrochloride is a potent and highly selective *histone lysine* demethylases 5 (KDM5) inhibitor with IC₅₀**s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells .

HY-179339

LSD1-IN-46	Histone Demethylase	Cancer
LSD1-IN-46 is a potent and orally active Lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 0.082 μM. LSD1-IN-46 interrupts the β-catenin-mediated transcriptional program, thereby suppressing the stemness of gastric cancer cells. LSD1-IN-46 exhibits strong anti-tumor activity. LSD1-IN-46 can be used for the research of gastric cancer .

Cat. No.	Product Name

HY-L024

Histone Modification Research Compound Library

904 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 904 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Cat. No.	Product Name	Target	Research Area

HY-P10819

S9-CMC1 TFA	Histone Demethylase Apoptosis	Cancer
S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ value of 2.53 μM. S9-CMC1 TFA specifically recognizes Cys360 in the enzyme-active region. S9-CMC1 TFA inhibits LSD1 activity, increasing H3K4me1 and H3K4me2 levels, leading to G1 cell cycle arrest and apoptosis and inhibiting cell proliferation. S9-CMC1 TFA significantly inhibits tumor growth in A549 xenograft animal models .

Species:	Human (9)
Tag:	SUMO (1) His (5) Tag Free (4) Myc (1) GST (1)
Source:	Sf9 insect cells (3) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701616

	PHF8 Protein, Human PHF8; Histone lysine demethylase PHF8; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8	Human	E. coli
	The PHF8 protein is a histone lysine demethylase that plays a key role in cell cycle progression, rDNA transcription, and brain development. It selectively demethylates H3 'Lys-9' (H3K9Me1 and H3K9Me2), H3 'Lys-27' (H3K27Me2) and H4 'Lys-20' (H4K20Me1). PHF8 Protein, Human is the recombinant human-derived PHF8 protein, expressed by E. coli , with tag free.

HY-P701617

	PHF8 Protein, Human (His) PHF8; Histone lysine demethylase PHF8; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8	Human	E. coli
	The PHF8 protein is a histone lysine demethylase that plays a key role in cell cycle progression, rDNA transcription, and brain development. It selectively demethylates H3 'Lys-9' (H3K9Me1 and H3K9Me2), H3 'Lys-27' (H3K27Me2) and H4 'Lys-20' (H4K20Me1). PHF8 Protein, Human (His) is the recombinant human-derived PHF8 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702082

	KDM6B Protein, Human (sf9) KDM6B; lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with tag free.

HY-P702083

	KDM6B Protein, Human (sf9, His) KDM6B; lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; lysine demethylase 6B; [histone H3]-trimethyl-L-lysine(27) demethylase 6B	Human	Sf9 insect cells
	KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9, His) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701618

	JMJD2A Protein, Human KDM4A; lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A	Human	E. coli
	The JMJD2A protein is a central histone demethylase in the histone code that specifically targets "Lys-9" and "Lys-36" of histone H3. It excludes demethylation of H3 "Lys-4", "Lys-27" and H4 "Lys-20". JMJD2A Protein, Human is the recombinant human-derived JMJD2A protein, expressed by E. coli , with tag free.

HY-P75551

	LSD1 Protein, Human (sf9, His-GST) 1 Publications Verification lysine-specific histone demethylase 1A; KDM1A; AOF2; KDM1; KIAA0601; LSD1	Human	Sf9 insect cells
	The LSD1 protein is a histone demethylase that modifies histone H3 by demethylating “Lys-4” (H3K4me) and “Lys-9” (H3K9me).It acts as a coactivator or corepressor, oxidizing substrates via FAD to generate imines that are subsequently hydrolyzed.LSD1 Protein, Human (sf9, His-GST) is the recombinant human-derived LSD1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701621

	KDM2A Protein, Human KDM2A; lysine-specific demethylase 2A; CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A	Human	E. coli
	The KDM2A protein is a histone demethylase targeting "Lys-36" of histone H3. It plays a key role in the histone code, especially the demethylation of dimethylated H3 "Lys-36". Methylation. In addition to histone demethylation, KDM2A also recognizes and binds phosphorylated proteins, promoting their ubiquitination and degradation. KDM2A Protein, Human is the recombinant human-derived KDM2A protein, expressed by E. coli , with tag free.

HY-P701622

	KDM2A Protein, Human (His) KDM2A; lysine-specific demethylase 2A; CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A	Human	E. coli
	The KDM2A protein is a histone demethylase targeting "Lys-36" of histone H3. It plays a key role in the histone code, especially the demethylation of dimethylated H3 "Lys-36". Methylation. In addition to histone demethylation, KDM2A also recognizes and binds phosphorylated proteins, promoting their ubiquitination and degradation. KDM2A Protein, Human (His) is the recombinant human-derived KDM2A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71585

	KDM3B Protein, Human (Myc, His-SUMO) 5qNCA; C5orf7; JHDM2B; JmjC domain containing histone demethylation protein 2B; JmjC domain-containing histone demethylation protein 2B; jmjd1b; Jumonji domain containing 1B; Jumonji domain containing protein 1B; Jumonji domain-containing protein 1B; KDM3B; KDM3B_HUMAN; KIAA1082; lysine (K) specific demethylase 3B ; lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA	Human	E. coli
	KDM3B protein is a histone demethylase that mainly targets "Lys-9" of histone H3, catalyzes demethylation and produces formaldehyde and succinic acid by-products. In addition to histone modifications, KDM3B has been implicated in tumor suppressor activity, indicating its importance in cellular processes, gene expression regulation, and epigenetic modifications. KDM3B Protein, Human (Myc, His-SUMO) is the recombinant human-derived KDM3B protein, expressed by E. coli , with C-Myc, N-SUMO, N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride

(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride . Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC₅₀s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression .

Host:	Mouse (13) Rabbit (9)
Reactivity:	Human (20) Bovine (3) Rat (7) Mouse (12) Monkey (3) Dog (3) human (2) Pig (1)
Application:	IHC-P (5) ICC/IF (15) IF-Tissue (1) IP (9) IHC-F (1) WB (22) FC (3) ELISA (3)
Isotype:	IgG (9) IgG1 (6)
Conjugation:	Non-conjugated (22)
Clonality:	Monoclonal (17) Recombinant (7)
Modification:	Unmodified (19)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83638

	KDM1B Antibody (YA3383) AOF1; KDM1B; LSD2; lysine-specific histone demethylase 1B; lysine-specific histone demethylase 2	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	KDM1B Antibody (YA3383) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM1B.

HY-P85484

	KDM1/LSD1 Antibody (YA5176) Amine oxidase; flavin containing; domain 2; AOF2; BHC110; BRAF35 HDAC complex protein BHC110; BRAF35-HDAC complex protein BHC110; FAD binding protein BRAF35 HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; KDM 1; KDM1; Kdm1a; KDM1A_HUMAN; LSD 1; LSD1; lysine; K; specific demethylase 1; lysine; K; specific demethylase 1A; lysine specific histone demethylase 1; lysine specific histone demethylase 1A; lysine-specific histone demethylase 1A.	WB, ICC/IF, IP	Human, Monkey
	KDM1/LSD1 Antibody (YA5176) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM1/LSD1.

HY-P83497

	Mint3 Antibody (YA3242) Histone lysine demethylase MINA; MDIG; MINA; NO52; ROX	WB, ICC/IF	Human, Mouse
	Mint3 Antibody (YA3242) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mint3.

HY-P810035

	SmcY Antibody (YA9379) HY, HYA, JARID1D, KIAA0234, SMCY, KDM5D, lysine-specific demethylase 5D, Histocompatibility Y antigen, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D, H-Y	WB, IP, ELISA	human
	SmcY Antibody (YA9379) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SmcY.

HY-P82579

	PHF8 Antibody (YA2324) Histone lysine demethylase PHF8; MRXSSD; PHD finger protein 8; PHF8; ZNF422	WB, ICC/IF, IP	Human, Mouse, Rat
	PHF8 Antibody (YA2324) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PHF8.

HY-P81319

	JMJD6 Antibody (YA1064) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human
	JMJD6 Antibody (YA1064) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to JMJD6.

HY-P85461

	JMJD6 Antibody (YA5153) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog
	JMJD6 Antibody (YA5153) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD6.

HY-P85467

	KDM5C/Jarid1C/SMCX Antibody (YA5159) KDM5C; DXS1272E; JARID1C; SMCX; XE169; lysine-specific demethylase 5C; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog
	KDM5C/Jarid1C/SMCX Antibody (YA5159) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.

HY-P81319A

	JMJD6 Antibody (YA1064)(PBS only) JMJD6; KIAA0585; PTDSR; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-diox	WB, ICC/IF	Human
	JMJD6 Antibody (YA1064) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to JMJD6.

HY-P86559

	KDM1/LSD1 Antibody (YA6251) lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	KDM1/LSD1 Antibody (YA6251) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM1/LSD1.

HY-P82791

	KDM4B Antibody (YA2536) KDM4B; JHDM3B; JMJD2B; KIAA0876; lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	KDM4B Antibody (YA2536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4B.

HY-P85482

	KDM5C/Jarid1C/SMCX Antibody (YA5174) DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C; RBP2 like; Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; lysine; K; specific demethylase 5C; lysine-specific demethylase 5C; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; SMCX; Smcx homolog X chromosome; SmcX protein; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein; Xe169 protein.	WB, ICC/IF	Human
	KDM5C/Jarid1C/SMCX Antibody (YA5174) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM5C/Jarid1C/SMCX.

HY-P85235

	JMJD1A Antibody (YA4927) KDM3A; JHDM2A; JMJD1; JMJD1A; KIAA0742; TSGA; lysine-specific demethylase 3A; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A	WB, ICC/IF, ELISA	Human
	JMJD1A Antibody (YA4927) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD1A.

HY-P80731

	KDM1/LSD1 Antibody (YA718) KDM1A; AOF2; KDM1; KIAA0601; LSD1; lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB	Human, Mouse, Monkey
	KDM1/LSD1 Antibody (YA718) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KDM1/LSD1.

HY-P85442

	KDM1/LSD1 Antibody (YA5134) KDM1A; AOF2; KDM1; KIAA0601; LSD1; lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB, IHC-P, ICC/IF	Human, Mouse, Bovine, Dog, Pig
	KDM1/LSD1 Antibody (YA5134) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM1/LSD1.

HY-P80731A

	KDM1/LSD1 Antibody (YA718)(PBS only) KDM1A; AOF2; KDM1; KIAA0601; LSD1; lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB	Human, Mouse, Monkey
	KDM1/LSD1 Antibody (YA718) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KDM1/LSD1.

HY-P83586

	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IP	Human
	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

HY-P85236

	KDM4A/JHDM3A/JMJD2A Antibody (YA4928) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IHC-P, IHC-F, IP, IF-Tissue	Human, Mouse, Rat
	KDM4A/JHDM3A/JMJD2A Antibody (YA4928) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

HY-P83586A

	KDM4A/JHDM3A/JMJD2A Antibody (YA3331)(PBS only) KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677; lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A	WB, IP	Human
	KDM4A/JHDM3A/JMJD2A Antibody (YA3331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4A/JHDM3A/JMJD2A.

HY-P85485

	JMJD6(N-term) Antibody (YA5177) Apoptotic cell clearance receptor; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD 6; JMJD6; JMJD6_HUMAN; Jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; PSR; PTDSR 1; PTDSR; PTDSR1.	WB, ICC/IF	Human
	JMJD6(N-term) Antibody (YA5177) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JMJD6(N-term).

HY-P810019

	NO66 Antibody (YA9363) C14orf169, MAPJD, NO66, RIOX1, Ribosomal oxygenase 1, 60S ribosomal protein L8 histidine hydroxylase, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Myc-associated protein with JmjC domain, Nucleolar protein 66, Ribosomal oxygenase NO66, hsNO66, ROX	WB, IP	human
	NO66 Antibody (YA9363) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NO66.

HY-P86931

	KDM3B Antibody (YA6624) 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; KDM3B_HUMAN antibody; KIAA1082 antibody; lysine (K) specific demethylase 3B antibody; lysine-specific demethylase 3B antibody; NET22 antibody; Nuclear protein 5qNCA antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse
	KDM3B Antibody (YA6624) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM3B.

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