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microtubule depolymerization activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (11) ADC Payload (1) Apoptosis (6) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Caspase (1) Drug Metabolite (1) Endogenous Metabolite (3) Kinesin (1) PARP (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) Ras (1) Reference Standards (3) TRP Channel (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST) MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N0227

7-epi-Taxol 4 Publications Verification 7-epi-Paclitaxel	Microtubule/Tubulin	Cancer
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting *microtubule* bundle formation and against microtubule depolymerization.

HY-B0011S

Docetaxel-d9 RP-56976-d₉	Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N2438

Methylophiopogonanone B 2 Publications Verification	Ras Microtubule/Tubulin	Cancer
Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer .

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Reference Standards Microtubule/Tubulin Apoptosis Endogenous Metabolite	Cancer
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-148128

TAM470	Microtubule/Tubulin ADC Payload	Cancer
TAM470 is a novel cytolysin, inhibiting tubulin polymerization and **microtubule depolymerization*. TAM470 can be used in the synthesis of OMTX705 as payload molecule, OMTX705 is a novel FAP-targeting antibody-drug conjugates (ADCs) with antitumor activity* .

HY-W008581

Estradiol 3-methyl ether 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol	Biochemical Assay Reagents TRP Channel Microtubule/Tubulin Autophagy	Metabolic Disease Cancer
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC₅₀ values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC₅₀ of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .

HY-157800

Trilexium TRX-E-009-1	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes *microtubules. Trilexium shows broad anti-cancer activity* .

HY-N0227R

7-epi-Taxol (Standard) 7-epi-Paclitaxel (Standard)	Reference Standards Microtubule/Tubulin	Cancer
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-135746R

OR-1896 (Standard)	Reference Standards Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis	Cardiovascular Disease
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-400684

Tubulysin A intermediate-1	Bacterial	Cancer
Tubulysin A intermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A (HY-15995). Tubulysin A (TubA) is an antibiotic, anti-microtubule toxins, and apoptosis inducer isolated from myxobacteria. Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A arrests cells in the G2/M phase, effectively inhibits tubulin polymerization, and induces depolymerization of detached microtubules. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC .

HY-177898

DHTP	Kinesin	Cancer
DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC₅₀ values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer .

HY-N16438

Phomopsin B	Microtubule/Tubulin	Cancer
Phomopsin B (Compound 3), a hexapeptide, is a *Microtubule* depolymerizer. Phomopsin B can be isolated from the fungus Phomopsis Leptostromiformis. Phomopsin B has an antimitotic activity. Phomopsin B can be used for cancers research .

HY-138008

WX-132-18B	Microtubule/Tubulin Apoptosis	Cancer
WX-132-18B is a tubulin inhibitor with an IC₅₀ of 0.45-0.99 nM. WX-132-18B selectively binds to the colchicine-binding site on tubulin, reduces microtubule content via depolymerization, and inhibits tubulin polymerization. WX-132-18B induces tumor cell cycle arrest, apoptosis and changes in nuclear membrane permeability, and decreases mitochondrial membrane potential. WX-132-18B exhibits antiproliferative activity against endothelial cells and human tumor cells, and inhibits the proliferation and growth of xenograft tumors in mice. WX-132-18B can be used in research related to sarcoma, non-small cell lung cancer, gastric cancer and breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0011

Docetaxel Maximum Cited Publications 158 Publications Verification RP-56976	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N0227

7-epi-Taxol 4 Publications Verification 7-epi-Paclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting *microtubule* bundle formation and against microtubule depolymerization.

HY-N2438

Methylophiopogonanone B 2 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Flavonoids Liliaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Other Flavonoids Disease Research Fields Source Classification	Ras Microtubule/Tubulin
Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer .

HY-B0011R

Docetaxel (Standard) RP-56976 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (Standard) is the analytical standard of Docetaxel. This product is intended for research and analytical applications. Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N0227R

7-epi-Taxol (Standard) 7-epi-Paclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd. Source Classification	Reference Standards Microtubule/Tubulin
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N16438

Phomopsin B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Microtubule/Tubulin
Phomopsin B (Compound 3), a hexapeptide, is a *Microtubule* depolymerizer. Phomopsin B can be isolated from the fungus Phomopsis Leptostromiformis. Phomopsin B has an antimitotic activity. Phomopsin B can be used for cancers research .

Cat. No.	Product Name	Chemical Structure

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

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microtubule depolymerization activity

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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