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Docetaxel hydrate

(Synonyms: RP-56976 hydrate)
186 Cited Publications
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Based on 186 publication(s) in Google Scholar

Docetaxel hydrate (RP-56976 hydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel hydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel hydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel hydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel hydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel hydrate can be used in cancer-related research.

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  • CAS No.: 700367-34-6
  • Formule: C43H55NO15
  • Masse moléculaire:825.89
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Docetaxel hydrate Chemical Structure
    Docetaxel hydrate Chemical Structure
  • Experimental Validation Results for Docetaxel hydrate
  • Experimental Validation Results for Docetaxel hydrate
  • Experimental Validation Results for Docetaxel hydrate
  • Experimental Validation Results for Docetaxel hydrate
  • Experimental Validation Results for Docetaxel hydrate
  • Experimental Validation Results for Docetaxel hydrate
CAS No.: 700367-34-6
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Apoptosis AnalysisWBCell Proliferation/Viability Assay
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  • Apoptosis Analysis
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  • Docetaxel hydrate Chemical Structure
    Docetaxel hydrate Chemical Structure
    1/16
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    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407662. [Abstract]

    Customer Validation
     Representative images and quantitative analysis of surviving clones after treatment of C4-2B and LNCaP cells with PBS or ECM1 protein (200 ng/mL) in the presence of docetaxel (10 μM) were shown.

  • 1/16

    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan;12(2):e2407662. [Abstract]

    Customer Validation
     Flow cytometry analysis showed representative images and quantification of apoptosis in C4-2B and LNCaP cells in the presence of docetaxel (10 μM). Docetaxel caused PCa cell apoptosis compared to that in the vehicle group.

  • 1/16

    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2024 Apr 3;16(741):eadj5705. [Abstract]

    Customer Validation
     Growth inhibition by docetaxel (Doc) (0–10 μM) in TS− or TS+ CAFs isolated from patients with BC was observed. The survival rates of TSPAN8+ CAFs were enhanced compared with TSPAN8− CAFs when challenged with an equal dosage of docetaxel.

  • 1/16

    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2023 May 3;16(1):46. [Abstract]

    Customer Validation
     Under docetaxel treatment (0.5 nM, 1 nM, 2.5 nM, 5 nM, 10 nM, 20 nM, 48 hours), myeloid-like tumor hybrid cells were less sensitive than the RM1 cell line.

  • 1/16

    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: Arch Biochem Biophys. 2023 Mar 15:737:109551. [Abstract]

    Customer Validation
     Docetaxel (30 nM) exhibits anti-tumor activity in parental (DU145 and PC-3) and docetaxel-resistant (DU145/DTX50 and PC-3/DTX30) cell lines by down-regulating KIF14 expression.

  • 1/16

    Docetaxel hydrate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 May 17;7(20):28891-902. [Abstract]

    Customer Validation
     Western blot analyses for Brachyury and AR expression in prostate cell lines treated with Docetaxel (Doc) or with XRP6258 (Cab). Graphs represent the densimetric semi-quantification of western blot images.

  • Docetaxel hydrate