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mutase

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By Targets:	Akt (1) Antibiotic (1) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (1) Calcium Channel (2) Carboxypeptidase (1) Endogenous Metabolite (8) ERK (1) Glucose-6-Phosphate Isomerase (GPI) (1) iGluR (2) Ligands for E3 Ligase (1) Nucleoside Antimetabolite/Analog (1) Phosphatase (5) Phosphomannose Isomerase (PMI) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3)
By Research Areas:	Cancer (6) Infection (4) Metabolic Disease (10)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0215

L-Phenylalanine 5+ Cited Publications (S)-2-Amino-3-phenylpropionic acid	Calcium Channel iGluR Endogenous Metabolite Ligands for E3 Ligase	Metabolic Disease Cancer
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-112790

Adenosylcobalamin 1 Publications Verification Coenzyme B12; Cobamamide; AdoCbl	Endogenous Metabolite	Metabolic Disease
Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-W015924

2-Hydroxyisobutyric acid	Endogenous Metabolite	Metabolic Disease
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-148510

HKB99	Phosphatase Apoptosis Akt ERK Reactive Oxygen Species (ROS)	Cancer
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .

HY-101143

PGMI-004A	Phosphatase	Cancer
PGMI-004A is a potent *phosphoglycerate mutase* 1 (PGAM1) inhibitor with an IC₅₀** of 13.1 μM.

HY-128681

PGAM1-IN-1 1 Publications Verification	Phosphatase	Cancer
PGAM1-IN-1 is a *phosphoglycerate mutase* 1 (PGAM1) inhibitor with an IC₅₀** of 6.4 μM .

HY-112790R

Adenosylcobalamin (Standard) Coenzyme B12 (Standard); Cobamamide (Standard); AdoCbl (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Adenosylcobalamin (Standard) is the analytical standard of Adenosylcobalamin. This product is intended for research and analytical applications. Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

HY-126791A

Methylmalonyl-CoA tetralithium Isosuccinyl coenzyme A tetralithium; Methylmalonyl coenzyme tetralithium	Endogenous Metabolite	Others
Methylmalonyl-CoA (Methylmalonyl coenzyme A) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl-CoA tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .

HY-W290527

2-Isopropyl-5-methylanisole	Antibiotic Bacterial	Infection
2-Isopropyl-5-methylanisole is an inhibitor of **Mycobacterium tuberculosis chorismate mutase (CM) with an IC₅₀ of 21.58 μM. The MIC** of 2-Isopropyl-5-methylanisole for Mycobacterium tuberculosis is 152.22 µM. 2-Isopropyl-5-methylanisole holds potential for research in the field of anti-infective studies .

HY-N0215R

L-Phenylalanine (Standard) (S)-2-Amino-3-phenylpropionic acid (Standard)	Reference Standards Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine (Standard) is the analytical standard of L-Phenylalanine. This product is intended for research and analytical applications. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-118391

Benzoyl-L-phenylalanine N-Benzoyl-L-phenylalanine; Bz-L-Phe-OH	Carboxypeptidase	Others
Benzoyl-L-phenylalanine (N-Benzoyl-L-phenylalanine) is a *chorisate mutase-prephenate dehydrogenase* inhibitor .

HY-128682

PGAM1-IN-2	Phosphatase	Cancer
PGAM1-IN-2 is a *phosphoglycerate mutase* 1 (PGAM1) inhibitor with an IC₅₀** of 2.1 μM .

HY-124890

Thr101	Phosphomannose Isomerase (PMI) Glucose-6-Phosphate Isomerase (GPI)	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

HY-W015924R

2-Hydroxyisobutyric acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

HY-128603

2-Hydroxyisobutyryl-CoA	Biochemical Assay Reagents	Metabolic Disease
2-Hydroxyisobutyryl-CoA is a hydroxy fatty acyl-CoA. 2-Hydroxyisobutyryl-CoA mutase forms the isomer (S)-3-hydroxybutyryl-CoA .

HY-151514

Antituberculosis agent-5	Bacterial	Infection
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC₅₀ value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .

HY-146652

UGM-IN-3	Bacterial	Infection
UGM-IN-3 (compound 10a) is a *UDP-galactopyranose mutase* (UGM) inhibitor with a K_d of 66 μM. UGM-IN-3 inhibits the growth of Mycobacterium tuberculosis** with a MIC value of 6.2 μg/mL .

HY-138877A

Phosphoglycolic acid lithium	Phosphatase	Cancer
Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid increases basal and fMLF-induced levels of G6P in intact neutrophils. Phosphoglycolic acid thereby increases upstream intermediates in neutrophils, thereby amplifying the respiratory oxidative burst .

HY-128753A

Lyxose	Endogenous Metabolite	Metabolic Disease
Lyxose is a pentose carbohydrate that serves both as a precursor for synthesizing UDP-galactopyranose mutase inhibitors in tuberculosis research and as an inhibitor of hSGLT5-mediated mannose uptake. The content of Lyxose in the cecum of mice fed a Western-style diet decreases .

HY-180597

3-Phospho-D-glycerate	Nucleoside Antimetabolite/Analog	Metabolic Disease
3-Phospho-D-glycerate can be converted to 2-phospho-d-glycerate (2-PGA) via phosphoglycerate mutase .

HY-180407

UGM-IN-1	Bacterial	Infection
UGM-IN-1 (compound 107) is a selective competitive inhibitor of Mycobacterium tuberculosis *UDP-Galp mutase* (UGM)*, encoded by Rv3809c. UGM-IN-1 inhibits the conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf), thereby blocking the synthesis of key components of the mycobacterial cell wall, including mycolic acid-arabinogalactan (mAG) and liparabinomannan (LAM), leading to anti-mycobacterial activity against Mycobacterium tuberculosis*. UGM-IN-1 is useful for research on tuberculosis, including drug-resistant tuberculosis .

L-Phenylalanine 5+ Cited Publications (S)-2-Amino-3-phenylpropionic acid	Structural Classification Microorganisms Animals Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Calcium Channel iGluR Endogenous Metabolite Ligands for E3 Ligase
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

Adenosylcobalamin 1 Publications Verification Coenzyme B12; Cobamamide; AdoCbl	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

2-Hydroxyisobutyric acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

Adenosylcobalamin (Standard) Coenzyme B12 (Standard); Cobamamide (Standard); AdoCbl (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Adenosylcobalamin (Standard) is the analytical standard of Adenosylcobalamin. This product is intended for research and analytical applications. Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B₁₂ which is a cofactor for methylmalonyl CoA mutase

Methylmalonyl-CoA tetralithium Isosuccinyl coenzyme A tetralithium; Methylmalonyl coenzyme tetralithium	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Methylmalonyl-CoA (Methylmalonyl coenzyme A) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl-CoA tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .

L-Phenylalanine (Standard) (S)-2-Amino-3-phenylpropionic acid (Standard)	Structural Classification Microorganisms Animals Amino acids Endogenous metabolite Source Classification	Reference Standards Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine (Standard) is the analytical standard of L-Phenylalanine. This product is intended for research and analytical applications. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

2-Hydroxyisobutyric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].

Lyxose	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Endogenous Metabolite
Lyxose is a pentose carbohydrate that serves both as a precursor for synthesizing UDP-galactopyranose mutase inhibitors in tuberculosis research and as an inhibitor of hSGLT5-mediated mannose uptake. The content of Lyxose in the cecum of mice fed a Western-style diet decreases .

3-Phospho-D-glycerate	Structural Classification Natural Products Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
3-Phospho-D-glycerate can be converted to 2-phospho-d-glycerate (2-PGA) via phosphoglycerate mutase .

Species:	Human (4)
Tag:	His (3) Strep (1) Tag Free (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701962

	PGAM1 Protein, Human 1 Publications Verification PGAM1; Phosphoglycerate mutase 1; BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human is the recombinant human-derived PGAM1 protein, expressed by E. coli , with tag free.

HY-P701963

	PGAM1 Protein, Human (His, StrepⅡ) PGAM1; Phosphoglycerate mutase 1; BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human (His, Strep) is the recombinant human-derived PGAM1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P7665

	BPGM Protein, Human (His) rHuBPGM, His; BPGM; Bisphosphoglycerate mutase;	Human	E. coli
	BPGM Protein, Human (His) expresses in E. coliwith a His tag. Bisphosphoglycerate mutase is an erythrocyte-specific enzyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3-bisphosphoglycerate, the allosteric effector of hemoglobin.

HY-P702869

	PGAM5 Protein, Human (His) Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5	Human	E. coli
	PGAM5 Protein, Human (His) is the recombinant human-derived PGAM5, expressed by E. coli , with C-6*His labeled tag. ,

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Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (3) ICC/IF (2) WB (4) FC (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Methylated (1) Unmodified (2)

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HY-P810611

	*Methylmalonyl Coenzyme A mutase* Antibody (YA9873)** MCM; Methylmalonyl CoA isomerase; Methylmalonyl CoA mutase mitochondrial; Methylmalonyl Coenzyme A mutase; Methylmalonyl-CoA isomerase; Methylmalonyl-CoA mutase; mitochondrial; Mut; MUTA_HUMAN	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Methylmalonyl Coenzyme A mutase Antibody (YA9873) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Methylmalonyl Coenzyme A mutase.

HY-P80222

	*Methylmalonyl Coenzyme A mutase* Antibody (YA295)**	WB, IHC-P	Human, Mouse, Rat
	Methylmalonyl Coenzyme A mutase Antibody (YA295) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Methylmalonyl Coenzyme A mutase.

HY-P810419

	GLO1 Antibody (YA9734) Aldoketomutase, glo1, GLOD1, Glx I, GLYI, glyoxalase domain containing 1, Glyoxalase I, Ketone aldehyde mutase, Ketone-aldehyde mutase, Lactoyl glutathione lyase	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	GLO1 Antibody (YA9734) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to GLO1.

HY-P87008

	PGAM5 Antibody (YA6701) Bcl-XL-binding protein v68 antibody; BXLBv68 antibody; MGC5352 antibody; mitochondrial antibody; PGAM5 antibody; PGAM5_HUMAN antibody; Phosphoglycerate mutase family member 5 antibody; Serine/threonine protein phosphatase PGAM5 mitochondrial antibody; Serine/threonine-protein phosphatase PGAM5 antibody;	WB	Human, Mouse, Rat
	PGAM5 Antibody (YA6701) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PGAM5.

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mutase

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