1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Adenosylcobalamin

Adenosylcobalamin  (Synonyms: Coenzyme B12; Cobamamide; AdoCbl)

Cat. No.: HY-112790 Purity: ≥98.0%
COA Handling Instructions

Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase

For research use only. We do not sell to patients.

Adenosylcobalamin Chemical Structure

Adenosylcobalamin Chemical Structure

CAS No. : 13870-90-1

Size Price Stock Quantity
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase[1]

In Vitro

Adenosylcobalamin serves as the cofactor for a group of enzymes that catalyze unusual rearrangement or elimination reactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1578.57

Formula

C72H99CoN18O17P

CAS No.
SMILES

O[[email protected]@H]1[[email protected]](O[[email protected]@H](N2C3=NC=NC(N)=C3N=C2)[[email protected]@H]1O)[CH-][Co+3]456([N]7=CN([[email protected]@H](O[[email protected]](CO)[[email protected]]8OP9([O-])=O)[[email protected]]8([H])O)C%10=CC(C)=C(C)C=C7%10)[N]%11=C%12[[email protected]@H](CCC(N)=O)[[email protected]@](CC(N)=O)(C)[[email protected]]%11(C)[[email protected]]([[email protected]](CC(N)=O)[[email protected]]%13(CCC(NC[[email protected]@H](C)O9)=O)C)([H])[N-]4C%13=C(C)C([[email protected]@H](CCC(N)=O)C%14(C)C)=[N]5C%14=CC%15=[N]6C([[email protected]](CC(N)=O)(C)[[email protected]@H]%15CCC(N)=O)=C%12C

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (15.84 mM; Need ultrasonic)

H2O : 5 mg/mL (3.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6335 mL 3.1674 mL 6.3348 mL
5 mM 0.1267 mL 0.6335 mL 1.2670 mL
10 mM 0.0633 mL 0.3167 mL 0.6335 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.58 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Adenosylcobalamin
Cat. No.:
HY-112790
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