149 Results for "

natural cytotoxicity

" in MedChemExpress (MCE) Product Catalog:
Products (149)

149 Results for "natural cytotoxicity" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-N1318
CAS No.: 19103-54-9
Synonyms: Psathyrotin
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis .
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3 Cited Publications
Cat. No.: HY-P9977
CAS No.: 2171511-58-1
Synonyms: JNJ-61186372

Target:  

EGFR

Research Areas:  

Cancer

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
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3 Cited Publications
Cat. No.: HY-N0591
CAS No.: 477-43-0
Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .
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3 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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1 Cited Publications
Cat. No.: HY-125098
CAS No.: 1149-99-1
Purity:  98.01%
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .
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1 Cited Publications
Cat. No.: HY-P99055
CAS No.: 934823-49-1
Synonyms: BMS-663513
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .
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1 Cited Publications
Cat. No.: HY-125938
CAS No.: 21238-33-5
Purity:  98.98%
Synonyms: Cycloartenol ferulate; Cycloartenol ferulic acid ester
Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity Kd = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention .
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1 Cited Publications
Cat. No.: HY-N7435
CAS No.: 54814-64-1
Synonyms: (±)-Massoia lactone
Massoia lactone ((±)-Massoia lactone) is a natural lactone-based biosurfactant with antifungal (fungal), antibiofilm, and cytotoxic activities. Massoia lactone inhibits fungal hyphal growth and spore germination, and induces fungal cell necrosis by forming membrane pores, reducing ergosterol, elevating ROS, and causing leakage of intracellular components. Massoia lactone inhibits the viability and proliferation of tumor cells. Massoia lactone degrades the extracellular polymeric substances of polymicrobial biofilms, penetrates the biofilm matrix, inhibits the growth of planktonic oral bacteria (bacterial), and reduces surface tension through its amphiphilic properties. Massoia lactone is a low-toxicity, biodegradable food additive with a coconut cream aroma, which can be used for flavor improvement and also serves as a quality control marker for Cs-4 mycelium. Massoia lactone can be used for research on Fusarium head blight, malignant tumors, and oral polymicrobial biofilm-associated dental diseases .
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Cat. No.: HY-117371
CAS No.: 157207-90-4
Purity:  99.90%
Synonyms: (-)-Hemiasterlin; Milnamide B
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .
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Cat. No.: HY-160421
CAS No.: 2000236-36-0
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .
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Cat. No.: HY-Y0493
CAS No.: 28230-32-2
Synonyms: HOOBt
Target:  

STAT HIV

Research Areas:  

Infection Cancer

HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .
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Cat. No.: HY-N2228
CAS No.: 83104-87-4
Synonyms: (-)-EGCG-3''-O-ME
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .
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Cat. No.: HY-N7933
CAS No.: 646-31-1
Synonyms: ALKANE C24
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology

Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .
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Cat. No.: HY-P5581
CAS No.: 347884-61-1
Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera) .
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Cat. No.: HY-N0446
CAS No.: 19685-10-0
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .
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Cat. No.: HY-N3057
CAS No.: 18956-15-5
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL) .
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Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Target:  

CD38 IFNAR

Research Areas:  

Cancer

Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma .
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Cat. No.: HY-N11519
CAS No.: 141360-90-9
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC50s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .
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Cat. No.: HY-N1155
CAS No.: 23407-76-3
Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.
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Cat. No.: HY-N3430
CAS No.: 16274-11-6
Synonyms: AF33
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .
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