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Results for "

natural cytotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (3) Akt (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (12) ATM/ATR (2) Autophagy (3) Bacterial (4) Biochemical Assay Reagents (1) C-type Lectin-like Receptors (CTLRs) (2) Caspase (2) CD38 (1) CDK (2) DNA Alkylator/Crosslinker (1) Drug Derivative (6) Drug Intermediate (1) EBV (1) EGFR (2) Endogenous Metabolite (4) Environmental Pollutants (1) ERK (1) Fungal (3) Hedgehog (3) HIV (2) HMG-CoA Reductase (HMGCR) (1) Insecticide (2) Integrin (1) Interleukin Related (4) Isotope-Labeled Compounds (1) JAK (1) MAPKAPK2 (MK2) (2) MHC (3) mRNA (2) NF-κB (2) NO Synthase (2) p38 MAPK (3) Parasite (3) PD-1/PD-L1 (1) Phospholipase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (8) ROS Kinase (2) SHP1 (1) STAT (4) TNF Receptor (5) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (4) Tyrosinase (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (80) Cardiovascular Disease (1) Infection (16) Inflammation/Immunology (28) Metabolic Disease (2) Neurological Disease (4)
Oligonucleotides:	mRNA (2) Interleukin & Receptors (1)

103

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-P9977

Amivantamab 3 Publications Verification JNJ-61186372	EGFR	Inflammation/Immunology Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99055

Urelumab	TNF Receptor	Inflammation/Immunology Cancer
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P9965

Elotuzumab HuLuc 63; PDL 063; BMS 901608	Transmembrane Glycoprotein	Cancer
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Payload	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-N1318

Salvigenin Maximum Cited Publications 6 Publications Verification Psathyrotin	Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N0591

Dehydrocostus Lactone 2 Publications Verification (-)-Dehydrocostus lactone; Epiligulyl oxide	Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase	Infection Inflammation/Immunology Cancer
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .

HY-160421

TREM2-IN-1	Apoptosis	Inflammation/Immunology Cancer
TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 ⁺ and CX₃CR1 ⁺ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .

HY-Y0493

HODHBt HOOBt	STAT HIV	Infection Cancer
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .

HY-125098

Illudin S 1 Publications Verification	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Others	Inflammation/Immunology Cancer
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .

HY-172240

Tosposertib TU2218 free base	Anaplastic lymphoma kinase (ALK) VEGFR	Inflammation/Immunology Cancer
Tosposertib (TU2218 free base) is an ALK5/VEGFR2 dual inhibitor (IC₅₀ = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer .

HY-N7933

Tetracosane ALKANE C24	Apoptosis	Inflammation/Immunology
Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

HY-P9977A

Amivantamab (FUT8-KO)	EGFR	Cancer
Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-N4202

Dihydrorotenone	Environmental Pollutants Insecticide Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD₅₀ of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .

HY-N6954

Garcinone C 2 Publications Verification	ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

HY-N0446

10-Methoxycamptothecin	ADC Payload	Cancer
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance .

HY-P990178

Anti-Mouse NKG2D/CD314 Antibody (CX5)	C-type Lectin-like Receptors (CTLRs)	Infection Others Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse NKG2D/CD314 Antibody (CX5) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (CX5) reduces cytotoxicity of natural killer cells. Anti-Mouse NKG2D/CD314 Antibody (CX5) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as colitis and diabetes .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Others	Cancer
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N11519

Polyporusterone C	Others	Cancer
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-174736

Human CD70 mRNA	mRNA	Inflammation/Immunology
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Others	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N1155

Theviridoside	Others	Cardiovascular Disease
Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.

HY-N3430

Kaempferol tetraacetate AF33	Others	Cancer
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

HY-W010533

(E)-2-Methyl-2-pentenoic acid	Drug Intermediate	Others
(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .

HY-N8679

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-129144

Dihydrodehydrodiconiferyl alcohol	TNF Receptor	Cancer
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-N15199

Schisanlactone A	Others	Cancer
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

HY-N7205

Glaucocalyxin D	Others	Cancer
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

HY-W391625

(Rac)-Dehydrocostus Lactone (Rac)-Epiligulyl oxide	Fungal	Cancer
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .

HY-175604

SCL-1	PD-1/PD-L1	Cancer
SCL-1 is an orally active anti-PD-1/PD-L1 inhibitor. SCL-1 can inhibit PD-1/PD-L1 binding. SCL-1 increases T cells, B cells and natural killer cells. SCL-1 exerts strong tumor growth inhibitory effects that were mediated by effector T-cell induction inside tumors and the up-regulated expression of long non-coding RNAs as neoantigens leading to cytotoxic T lymphocyte activation. SCL-1 can be used for the research of cancer, such as triple-negative breast cancer .

HY-133220A

Guajadial F	Others	Cancer
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

HY-N12524

Cyclo(prolyltyrosyl)	Bacterial	Infection Cancer
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Reference Standards Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis .

HY-P990719

Efbalropendekin alfa XmAb24306	Interleukin Related	Inflammation/Immunology Cancer
Efbalropendekin Alfa (XmAb24306) is an IL-15/IL-15 receptor alpha complex fused to a heterodimeric Fc domain (IL15/IL15Rα-Fc). Efbalropendekin Alfa increases direct and antibody-dependent cellular cytotoxicity (ADCC)-mediated human natural killer (NK) cell cytotoxicity in vitro .

HY-N0763R

Angelicin (Standard) Isopsoralen (Standard)	Reference Standards Apoptosis Virus Protease	Cancer
Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC₅₀: 49.56 μM; inhibits MHV-68, IC₅₀: 5.39 μg/ml (28.95 μM).

HY-N9170

Lup-20(29)-ene-3β,11β-diol	Drug Derivative	Cancer
Lup-20(29)-ene-3β,11β-diol is a natural triterpenoid with anticancer effects. Lup-20(29)-ene-3β,11β-diol exhibits significant cytotoxic activity against HeLa with an IC₅₀ value of 28.5 μM .

HY-129149

Ganoderic acid SZ	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-N16580

(+)-Lariciresinol 9′-p-coumarate	Others	Cancer
(+)-Lariciresinol 9′-p-Coumarate is a type of lignan. (+)-Lariciresinol 9′-p-Coumarate exhibits inhibitory activity against leukemia and other tumor cell lines .

HY-P11340

VMAPRTLFL	MHC	Infection Inflammation/Immunology
VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ ^- adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity .

HY-N8088

Neolancerin	Others	Cancer
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-156186

Anticancer agent 160	Others	Cancer
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC₅₀=5.0 μM .

HY-122948

Isogambogenic acid	Others	Cancer
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Others	Cancer
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

Cat. No.	상품명	Target	Research Area

HY-P5581

Alloferon 1	Peptides	Infection Inflammation/Immunology Cancer
Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera) .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P11340

VMAPRTLFL	MHC	Infection Inflammation/Immunology
VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ ^- adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity .

HY-P11713

EBNA3B 399-408	EBV MHC	Infection Cancer
EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma .

HY-P11397

VLPDVFIRCV	MHC	Cancer
VLPDVFIRCV, a melanoma antigen-derived peptide, is the intron sequence (nt 38-67) of the N-acetylglucosamine transferase V (GnT-V) gene. VLPDVFIRCV has a high affinity for MHC-I class molecules, but it cannot activate the immune response against natural tumor cells. The cytotoxic T lymphocytes (CTL) induced by VLPDVFIRCV can specifically lyse T2 cells loaded with this peptide in the chromium release experiment. VLPDVFIRCV can be used for vaccine design research .

Cat. No.	상품명	Target	Research Area	Image

HY-P9977

Amivantamab 3 Publications Verification JNJ-61186372	EGFR	Inflammation/Immunology Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99055

Urelumab	TNF Receptor	Inflammation/Immunology Cancer
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P9965

Elotuzumab HuLuc 63; PDL 063; BMS 901608	Transmembrane Glycoprotein	Cancer
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma .

HY-P99389

Tesnatilimab JNJ-64304500; IPH-2301; NN-8555	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Tesnatilimab (JNJ-64304500) is a human IgG4 monoclonal antibody targeting NKG2D, with a K_D value of 9.2 pM . Tesnatilimab blocks the binding of ligands to the NKG2D receptor, thereby inhibiting downstream proinflammatory cytokine, cytotoxic mediator signaling pathways and proinflammatory immune responses. Tesnatilimab is applicable to research related to Crohn's disease .

HY-P991558

RO-5429083 RG-7356	Transmembrane Glycoprotein	Cancer
RO-5429083 (RG-7356) is a humanized monoclonal antibody targeting CD44. RO-5429083 binds to the extracellular domain of CD44 and inhibits constitutive EGFR phosphorylation. RO-5429083 suppresses tumor growth in xenograft models and can be used in research related to head and neck squamous cell carcinoma and acute myeloid leukemia .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

HY-P9977A

Amivantamab (FUT8-KO)	EGFR	Cancer
Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99622

Flanvotumab IMC-20D7S	Tyrosinase	Cancer
Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance .

HY-P990178

Anti-Mouse NKG2D/CD314 Antibody (CX5)	C-type Lectin-like Receptors (CTLRs)	Infection Others Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse NKG2D/CD314 Antibody (CX5) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (CX5) reduces cytotoxicity of natural killer cells. Anti-Mouse NKG2D/CD314 Antibody (CX5) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as colitis and diabetes .

HY-P991136

Etuptamig	Inhibitory Antibodies	Cancer
Etuptamig is a chimeric monoclonal antibody of immunoglobulin λ-chain-γ1, λ-chain-γ3 targeting human natural killer cell cytotoxicity receptor 1 (NCR1). Etuptamig is promising for research of various cancers .

HY-P990719

Efbalropendekin alfa XmAb24306	Interleukin Related	Inflammation/Immunology Cancer
Efbalropendekin Alfa (XmAb24306) is an IL-15/IL-15 receptor alpha complex fused to a heterodimeric Fc domain (IL15/IL15Rα-Fc). Efbalropendekin Alfa increases direct and antibody-dependent cellular cytotoxicity (ADCC)-mediated human natural killer (NK) cell cytotoxicity in vitro .

HY-P991250

MSH-TP15e	Integrin	Cancer
MSH-TP15e is a humanized monoclonal antibody inhibitor targeting intercellular adhesion molecule-1 (ICAM-1). MSH-TP15e recruits natural killer cells and significantly triggers antibody-dependent cell-mediated cytotoxicity (ADCC) to inhibit tumor cell growth. MSH-TP15e is promising for research of multiple myeloma (MM) .

HY-P992361

HB0030	Transmembrane Glycoprotein	Cancer
HB0030 is a TIGIT inhibitor with antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities. HB0030 enhances the expression of activation markers in natural killer (NK) cells, promotes the killing of regulatory T cells (Tregs), and reduces the proportion of FoxP3 ⁺ Treg in tumor-infiltrating lymphocytes. The combination of HB0030 with the anti-PD-L1/VEGF bispecific antibody HB0025 further enhances tumor suppression efficacy. HB0030 can be used in studies related to colorectal cancer, pancreatic adenocarcinoma, hepatocellular carcinoma, bladder cancer, breast cancer, non-small cell lung cancer, and advanced solid tumors .

HY-P992450

REGN6569	TNF Receptor	Cancer
REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001 .

HY-P99014A

Cusatuzumab (FUT8-KO)	Transmembrane Glycoprotein	Cancer
Cusatuzumab (FUT8-KO) is an anti-CD70 monoclonal antibody that prepared by knocking out the fucosyltransferase 8 gene (FUT8) to remove fucose and thereby enhance the ADCC activity of the antibody .

HY-P991530

YH004	Biochemical Assay Reagents	Inflammation/Immunology Cancer
YH004 is an anti-CD137 agonistic monoclonal antibody, with immunostimulating and antineoplastic activities. YH004 activates CD137 expressed on a variety of leukocyte subsets including activated T lymphocytes and natural killer cells. YH004 enhances CD137-mediated signaling and induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes anti-tumor response mediated by CTL. YH004 induces NK-mediated tumor cell killing and suppresses the immunosuppressive activity of regulatory T cells. YH004 can be studied in anticancer research .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Payload
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-N1318

Salvigenin Maximum Cited Publications 6 Publications Verification Psathyrotin	Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N0591

Dehydrocostus Lactone 2 Publications Verification (-)-Dehydrocostus lactone; Epiligulyl oxide	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer	Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .

HY-125098

Illudin S 1 Publications Verification	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Disease Research Fields Source Classification	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N2228

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (-)-EGCG-3''-O-ME	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	Others
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product that can be isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3''-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells .

HY-N4202

Dihydrorotenone	Structural Classification Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Plants Convolvulaceae Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Insecticide Apoptosis p38 MAPK
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD₅₀ of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .

HY-N6954

Garcinone C 2 Publications Verification	other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	ATM/ATR STAT CDK Hedgehog
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

HY-N0446

10-Methoxycamptothecin	Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer Source Classification	ADC Payload
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-125938

Cycloartenyl ferulate 1 Publications Verification Cycloartenol ferulate; Cycloartenol ferulic acid ester	Triterpenes Monophenols other families Classification of Application Fields Terpenoids Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Derivative Apoptosis Reactive Oxygen Species (ROS) JAK STAT
Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity K_d = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention .

HY-N3057

Pinostrobin chalcone	Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Disease Research Fields Cajanus cajan (L.) Millsp. Source Classification Cancer	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Apocynaceae Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Apocyniveneti Folium Disease Research Fields Source Classification Cancer	Others
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N11519

Polyporusterone C	Microorganisms Terpenoids Diterpenoids Source Classification	Others
Polyporusterone C (Compound 3) is a natural product that can be isolated from Polyporus umbellatus. Polyporusterone C shows cytotoxic activities with IC₅₀s of 37, 26 and 42 μg/mL against L-1210 cells at 3, 5 and 7 days, respectively .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Structural Classification Alkaloids Solanum melongena L. Solanaceae Plants Indole Alkaloids Source Classification	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N1155

Theviridoside	Cardiovascular Disease other families Iridoids Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	Others
Theviridoside is a natural iridoid glucoside found in the leaves of Cerbera odollam, it has cytotoxicity.

HY-N3430

Kaempferol tetraacetate AF33	Flavonoids Flavones Rosaceae Plants Source Classification Fragaria × ananassa Duch.	Others
Kaempferol tetraacetate (AF33) is a natural product. Kaempferol tetraacetate shows cytotoxicity .

HY-N8679

Physalin C	Cardiacglycosides Physalis angulata L. Plants Solanaceae Steroids Source Classification	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-129144

Dihydrodehydrodiconiferyl alcohol	Structural Classification Anogeissus acuminata (Roxb. ex DC.) Guill. Monophenols Combretaceae Phenols Plants Source Classification	TNF Receptor
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

HY-N15199

Schisanlactone A	Triterpenes Structural Classification Terpenoids Cardiacglycosides Schisandra henryi subsp. yunnanensis (A. C. Smith) R. M. K. Saunders Plants Schisandraceae Steroids Source Classification	Others
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

HY-N7205

Glaucocalyxin D	Terpenoids Labiatae Diterpenoids Plants Glycyrrhiza lepidota Pursh Source Classification	Others
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

HY-133220A

Guajadial F	Other Monoterpenes Terpenoids Psidium guajava Linn. Myrtaceae Plants Source Classification	Others
Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .

HY-N12524

Cyclo(prolyltyrosyl)	Alkaloids Pyrrole Alkaloids Endogenous metabolite Source Classification	Bacterial
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Alkaloids other families Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants	Parasite
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N1912

Andropanolide	Structural Classification Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Structural Classification Monophenols Flavonoids other families Flavones Phenols Plants Source Classification	Reference Standards Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis .

HY-N0763R

Angelicin (Standard) Isopsoralen (Standard)	Structural Classification Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Source Classification	Reference Standards Apoptosis Virus Protease
Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC₅₀: 49.56 μM; inhibits MHV-68, IC₅₀: 5.39 μg/ml (28.95 μM).

HY-129149

Ganoderic acid SZ	Microorganisms Ketones, Aldehydes, Acids Source Classification	HMG-CoA Reductase (HMGCR)
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-N16580

(+)-Lariciresinol 9′-p-coumarate	Structural Classification Larix olgensis A. Henry Pinaceae Lignans Phenols Polyphenols Phenylpropanoids Plants Source Classification	Others
(+)-Lariciresinol 9′-p-Coumarate is a type of lignan. (+)-Lariciresinol 9′-p-Coumarate exhibits inhibitory activity against leukemia and other tumor cell lines .

HY-N8088

Neolancerin	other families Xanthones Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Others
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-122948

Isogambogenic acid	Flavonoids Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Others
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-N8317

Rubicordifolin	Natural Products Rubiaceae Plants Source Classification Rubia cordifolia L.	Others
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-N8915

Deoxyflindissone	Triterpenes Cornaceae Terpenoids Cornus walteri Wangerin Plants Source Classification	Others
Deoxyflindissone (Compound 13) is a triterpenoid compound. Deoxyflindissone is isolated from natural Cornus walteri .Deoxyflindissone has significant cytotoxic activity .

HY-N10363

Pixinol	Triterpenes Classification of Application Fields Juglandaceae Terpenoids Cyclocarya paliurus (Batal.) Iljinsk. Plants Disease Research Fields Cancer Source Classification	Others
Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC₅₀=71 µM and 43 µM, respectively) .

HY-N6582

Flavokawin C	Chalcones Flavonoids Humulus lupulus L. Plants Moraceae Source Classification	Others
Flavokawin C is a natural compound with antioxidative and cytotoxicity .

HY-118306

Amphidinolide F	Natural Products Marine natural products Marine microorganism Source Classification	Others
Amphidinolide F is a cytotoxic marine natural product contains a macrolactone .

HY-133220

Guajadial E	Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants Source Classification	Others
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

HY-N12192

Ebenifoline E-II	Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Celastraceae Euonymus laxiflorus Champ. ex Benth. Plants Source Classification	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-N2852

α-Terthienylmethanol	Natural Products Alysicarpus ovalifolius (Schumacher) J. Leonard Plants Compositae Source Classification	Reactive Oxygen Species (ROS)
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-N7011

Epicorynoxidine	Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Source Classification	Others
Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .

HY-N1081A

Viteralone (S)-Viteralone	Terpenoids Verbenaceae Sesquiterpenes Plants Vitex negundo Linn.	Others
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-133223

Hispidanin B	Isodon hispidus (Bentham) Murata Terpenoids Labiatae Diterpenoids Plants Source Classification	Others
Hispidanin B is a natural product that can be extracted from the rhizomes of Isodon hispida. Hispidanin B has cytotoxic activities against cancer cells .

HY-N8739

2-Hydroxyxanthone	Flavonoids Calophyllum inophyllum L. Plants Calophyllaceae Other Flavonoids Source Classification	Endogenous Metabolite
2-Hydroxyxanthone (Compound 3) is an isoprene flavone derived from Calophyllum inophyllum. 2-Hydroxyxanthone has an obvious killing effect on K562 cells .

HY-143242

Phidianidine B	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Other Diseases Marine microorganism Disease Research Fields	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

HY-N14309

Astechrome	Natural Products Microorganisms Source Classification	Parasite
Astechrome is a natural product with a strong antimalarial activity with an IC₅₀ value of 0.94 μM. Astechrome exhibits cytotoxicity against Vero cells with IC₅₀ value of 7.9 μM .

HY-129148

Ganoderic acid AM1 GAAM1	Triterpenes Microorganisms Terpenoids Source Classification	Others
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-N3966

Goniodiol 8-acetate	Natural Products Goniothalamus amuyon (Bl.) Merr. Plants Annonaceae Source Classification	Others
Goniodiol 8-acetate is a styrylpyrones that can be isolated from the leaves of Goniothalamus amuyon. Goniodiol 8-acetate has cytotoxic activity .

HY-N8846

dl-Aloesol	Flavonoids Microorganisms Other Flavonoids Source Classification	Fungal
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .

HY-N3722

O-Demethylmurrayanine	Monophenols Clausena lansium (Lour.) Skeels Rutaceae Phenols Plants Source Classification	Others
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-N12128

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Plants Steroids Source Classification	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-N12142

Anticancer agent 156	Classification of Application Fields Antibiotics Miliusa sinensis Finet et Gagnep. Plants Annonaceae Disease Research Fields Other Antibiotics Cancer Source Classification	Others
Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .

HY-N2445R

Flavokawain C (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Piperaceae Piper methysticum G.Forst. Plants Source Classification	Reference Standards Apoptosis
Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

Species:	Human (9) Rhesus Macaque (1) Rat (3) Cynomolgus (2)
Tag:	His (9) Avi (1) Fc (6)
Source:	HEK293 (15)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P77106

	NKp30/NCR3 Protein, Rat (HEK293, His) natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3	Rat	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on natural killer (NK) cells that activates cytotoxicity by binding to ligands such as BAG6 and NCR3LG1, stimulating NK cells to respond against neighboring cells (including tumor cells) expressing these ligands. NKp30/NCR3 Protein, Rat (HEK293, His) is the recombinant rat-derived NKp30/NCR3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72502

	NKp44/NCR2 Protein, Human (HEK293, His) natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95	Human	HEK293
	The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70174

	NKp46/NCR1 Protein, Human (HEK293, Fc) rHunatural cytotoxicity Triggering Receptor 1/NCR1, Fc; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293
	NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function. NKp46/NCR1 Protein, Human (HEK293, Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704824

	NKp46/NCR1 Protein, Human (HEK293, Llama Fc) rHunatural cytotoxicity Triggering Receptor 1/NCR1, Fc; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293
	NKp46/NCR1 protein, a cytotoxicity-activating receptor on natural killer (NK) cells, potentially enhances their efficacy in tumor cell lysis. Interacting with CD247 and FCER1G, NKp46/NCR1 plays a pivotal role in signaling pathways associated with NK cell activation and cytotoxicity. It contributes to the regulatory network for recognizing and eliminating target cells, emphasizing its importance in immune surveillance and anti-tumor responses. NKp46/NCR1 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P74685

	NKp44/NCR2 Protein, Human (Biotinylated, HEK293, His) natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95	Human	HEK293
	The NKp44/NCR2 protein is a cytotoxicity-activating receptor on natural killer (NK) cells that may increase their tumor cell lysis efficiency. NKp44/NCR2 interacts with TYROBP/DAP12, an important signal transduction adapter, and is critical for transducing signals that activate NK cells against target cells. NKp44/NCR2 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived NKp44/NCR2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704961

	NKp44/NCR2 Protein, Human (HEK293, Llama Fc) natural cytotoxicity triggering receptor 2; NKp44; CD336; NCR2; LY95	Human	HEK293

HY-P705169

	NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His-Avi) rHunatural cytotoxicity Triggering Receptor 1/NCR1, Fc; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293

HY-P72506

	NKp30/NCR3 Protein, Human (HEK293, His) NCR3 Protein; natural cytotoxicity Triggering Receptor 3; NCR3; CD337; 1C7; LY117	Human	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on NK cells and is activated by binding to ligands such as BAG6 and NCR3LG1. This activation enhances NK cell cytotoxicity against neighboring cells that produce these ligands, including tumor cells. NKp30/NCR3 Protein, Human (HEK293, His) is the recombinant human-derived NKp30/NCR3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72839

	B7-H6 Protein, Human (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Human	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (HEK293, Fc) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75483

	B7-H6 Protein, Rat (HEK293, His) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Rat	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76743

	B7-H6 Protein, Cynomolgus (HEK293, His) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Cynomolgus	HEK293
	B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75484

	B7-H6 Protein, Rat (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Rat	HEK293
	B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76742

	B7-H6 Protein, Cynomolgus (HEK293, Fc) natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1	Cynomolgus	HEK293
	B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77452

	NKp30/NCR3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) NCR3 Protein; natural cytotoxicity Triggering Receptor 3; NCR3; CD337; 1C7; LY117	Rhesus Macaque	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on natural killer (NK) cells that activates cytotoxicity by binding to ligands such as BAG6 and NCR3LG1, stimulating NK cells to respond against neighboring cells (including tumor cells) expressing these ligands. NKp30/NCR3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived NKp30/NCR3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7631

	B7-H6 Protein, Human (HEK293, His) rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; natural cytotoxicity triggering receptor 3 ligand 1	Human	HEK293
	B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis.

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Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
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Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / 해외재고보유 - + 장바구니에 담기 견적 받기

Cat. No.	상품명	Chemical Structure

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties .

HY-Y0790S

Cuminaldehyde-d8
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (4) Mouse (1)
Application:	IHC-P (3) WB (1) FC (1) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (4) Biotin (2)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

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HY-P81447

	NCR1 Antibody (YA1192) natural cytotoxicity triggering receptor 1; LY94; CD335; NKP46; NK-p46	IHC-P	Human
	NCR1 Antibody (YA1192) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCR1.

HY-P81447A

	NCR1 Antibody (YA1192)(PBS only) natural cytotoxicity triggering receptor 1; LY94; CD335; NKP46; NK-p46	IHC-P	Human
	NCR1 Antibody (YA1192) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCR1.

HY-P84990

	NKp30 Antibody (YA4682) 1C7 antibody; Activating natural killer receptor p30 antibody; Activating NK A1 receptor antibody; CD337 antibody; CD337 antigen antibody; LY117 antibody; Lymphocyte antigen 117 antibody; MALS antibody; natural cytotoxicity triggering receptor 3 antibody; natural killer cell p30 related protein antibody; natural killer cell p30-related protein antibody; Ncr3 antibody; NCTR3_HUMAN antibody; NK-p30 antibody; NKp30 antibody; CD337 nanobody;	ELISA, FC	Human
	NKp30 Antibody (YA4682) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NKp30.

HY-P86988

	NK-p44 Antibody (YA6681) Activating NK receptor NKp44 antibody; CD336 antibody; CD336 antigen antibody; dJ149M18.1 antibody; LY95 antibody; Lymphocyte antigen 95 (activating NK receptor NK p44) antibody; Lymphocyte antigen 95 homolog (activating NK receptor NK p44) antibody; Lymphocyte antigen 95 homolog antibody; Activating NK receptor NKp44 antibody; CD336 antibody; CD336 antigen antibody; dJ149M18.1 antibody; LY95 antibody; Lymphocyte antigen 95 (activating NK receptor NK p44) antibody; Lymphocyte antigen 95 homolog (activating NK receptor NK p44) antibody; Lymphocyte antigen 95 homolog antibody; Lymphocyte antigen 95, mouse, homolog of antibody; natural cytotoxicity triggering receptor 2 antibody; natural killer cell p44 related protein antibody; natural killer cell p44-related protein antibody; NCR2 antibody; NCTR2_HUMAN antibody; NK cell activating receptor (NKp44) antibody; NK cell activating receptor antibody; NK cell-activating receptor antibody; NK p44 antibody; NK-p44 antibody; NKp44 antibody;	WB, IHC-P	Human, Mouse
	NK-p44 Antibody (YA6681) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NK-p44.

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Molecular Weight
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Appearance
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Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / 해외재고보유 - + 장바구니에 담기 견적 받기

Cat. No.	상품명		Classification

HY-174736

Human CD70 mRNA		mRNA
Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

HY-174622

Human IL21 mRNA		mRNA Interleukin & Receptors
Human IL21 mRNA encodes the human interleukin 21 (IL21) protein, a member of the common-gamma chain family of cytokines. IL21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells.

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