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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
ototoxic
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "ototoxic" in MCE Product Catalog:
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Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies .
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11 Cited Publications
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EPZ020411 hydrochloride is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC50 of 0.010 μM. EPZ020411 hydrochloride blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 hydrochloride is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma .
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11 Cited Publications
Research Areas:
EPZ020411 is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC50 of 0.010 μM. EPZ020411 blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma .
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1 Cited Publications
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KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
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Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .
Cat. No.: HY-B0509AR
CAS No.: 37517-28-5
Synonyms: BAY 41-6551 (Standard)
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Amikacin (Standard) is the analytical standard of Amikacin. This product is intended for research and analytical applications. Amikacin (BAY 41-6551), a semisynthetic analog of kanamycin, is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin (BAY 41-6551) is ototoxic and nephrotoxic .
Cat. No.: HY-18673
CAS No.: 312951-85-2
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PROTO-1 is a hair cell protector and can be used in studies of ototoxicity-induced hair cell death .
Cat. No.: HY-P11350
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Cat. No.: HY-P11350A
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Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .
Cat. No.: HY-B0639C
CAS No.: 59178-37-9
Synonyms: WR2721 sodium
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Amifostine sodium (WR2721 sodium) is a phosphorus sulfate with radioprotective activity. Amifostine sodium can cause splenic vasodilation and may block autonomic ganglia. Amifostine sodium is clinically used to prevent cisplatin-induced ototoxicity .
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Dihydrostreptomycin (sulfate) (Standard) is the analytical standard of Dihydrostreptomycin (sulfate) (HY-B1241). This product is intended for research and analytical applications. Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .
Cat. No.: HY-128895A
CAS No.: 1800406-26-1
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KL1333 hydrochloride is an orally active NAD + modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD + levels through NADH oxidation. Elevated NAD + levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .
Cat. No.: HY-182622
CAS No.: 59711-96-5
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Etimicin is a fourth-generation semisynthetic aminoglycoside antibiotic. Etimicin exhibits broad spectrum of activity against gram-positive, gram-negative, and aminoglycoside-resistant bacterial strains, with lower ototoxicity and nephrotoxicity. Etimicin exerts rapid, concentration-dependent bactericidal activity against bacteria. Etimicin can be used for the research of bacterial infections .
Cat. No.: HY-12970B
CAS No.: 2095432-47-4
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EPZ020411 dihydrochloride is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC50 of 0.010 μM. EPZ020411 dihydrochloride blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 dihydrochloride is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
