39 Results for "

polyphenol inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (39)

39 Results for "polyphenol inhibitor" in MCE Product Catalog:

65
(-)-Epigallocatechin Gallate
(-)-Epigallocatechin Gallate
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65 Publications Verification
Cat. No.: HY-13653
CAS No.: 989-51-5
Purity:  99.75%
Synonyms: EGCG; Epigallocatechol Gallate
Category:  

Anti-aging Plants Endogenous metabolite other families Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Apoptosis

(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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17
Punicalagin
Punicalagin
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17 Cited Publications
Cat. No.: HY-N0063
CAS No.: 65995-63-3
Category:  

Infection Punica granatum L. Metabolic Disease Phenols Polyphenols Punicaceae Plants Disease Research Fields

Target:  

SARS-CoV HBV

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
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5
Arbutin
Arbutin
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5 Cited Publications
Cat. No.: HY-N0192
CAS No.: 497-76-7
Synonyms: β-Arbutin
Category:  

Bergenia purpurascens (Hook. f. et Thoms.) Engl. Human Gut Microbiota Metabolites Microorganisms Phenols Plants Saxifragaceae Endogenous metabolite Disease Research Fields Cancer

Target:  

Tyrosinase Endogenous Metabolite

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Ki app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .
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4
Isorhapontigenin
Isorhapontigenin
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4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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1
Agrimol B
Agrimol B
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1 Cited Publications
Cat. No.: HY-N0704
CAS No.: 55576-66-4
Category:  

Agrimonia pilosa Ledeb. Rosaceae Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial

Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .
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1
Procyanidol B4
Procyanidol B4
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1 Cited Publications
Cat. No.: HY-107208
CAS No.: 29106-51-2
Purity:  99.89%
Synonyms: (-)-Procyanidin B4
Category:  

other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Biflavones

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) COX Interleukin Related NO Synthase

Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS .
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1
(±)-Catechin
(±)-Catechin
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1 Cited Publications
Cat. No.: HY-B1890
CAS No.: 7295-85-4
Synonyms: rel-Cianidanol; rel-Catechuic acid
Category:  

Cardiovascular Disease Neurological Disease Plants Camellia sinensis (L.) O. Ktze. Infection Phenols Polyphenols Disease Research Fields Inflammation/Immunology Theaceae

Target:  

COX

(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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1
3-Hydroxyhippuric acid
3-Hydroxyhippuric acid
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1 Cited Publications
Cat. No.: HY-113085
CAS No.: 1637-75-8
Purity:  99.83%
Category:  

Monophenols Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

3-Hydroxyhippuric acid is an acylglycine. 3-Hydroxyhippuric acid inhibits kynureninase (Ki=60 μM). The concentration of 3-Hydroxyhippuric acid in autistic experimental groups is higher than that in control groups. 3-Hydroxyhippuric acid is a biomarker for Clostridium and is positively correlated with the content of Clostridium. 3-Hydroxyhippuric acid is one of the major metabolites of catechin-rich and wine polyphenol-rich diets. 3-Hydroxyhippuric acid can be used in the research of neurodegenerative diseases and autism spectrum disorders .
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Hamamelitannin
Hamamelitannin
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Cat. No.: HY-N4117
CAS No.: 469-32-9
Category:  

Infection Hamamelis mollis Oliver Hamamelidaceae Phenols Polyphenols Plants Disease Research Fields

Target:  

Bacterial

Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .
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(-)-Epigallocatechin Gallate (Standard)
(-)-Epigallocatechin Gallate (Standard)
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Cat. No.: HY-13653R
CAS No.: 989-51-5
Purity:  98.05%
Synonyms: EGCG(Standard); Epigallocatechol Gallate (Standard)
Category:  

other families Flavonoids Anti-aging Phenols Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Reference Standards Endogenous Metabolite Apoptosis

(-)-Epigallocatechin Gallate (Standard) is the analytical standard of (-)-Epigallocatechin Gallate. This product is intended for research and analytical applications. (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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N-(p-Coumaroyl) Serotonin
N-(p-Coumaroyl) Serotonin
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Cat. No.: HY-129440
CAS No.: 68573-24-0
Purity:  99.03%
Category:  

Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Toll-like Receptor (TLR) p38 MAPK NO Synthase COX ERK Caspase PDGFR MyD88 Reactive Oxygen Species (ROS) Apoptosis

N-(p-Coumaroyl) Serotonin is an orally active polyphenol found in safflower seeds with potent anti-inflammatory, antioxidant, and antitumor activities. N-(p-Coumaroyl) Serotonin suppresses NF‑κB, TLR4/MyD88 and MAPK signaling, activates NQO1/HO‑1 pathways, and inhibits pro‑inflammatory cytokines, iNOS and COX‑2 and ROS production. N-(p-Coumaroyl) Serotonin induces S‑phase arrest and apoptosis in glioblastoma cells, reduces atherosclerotic lesions, and alleviates renal and vascular injuries. N-(p-Coumaroyl) Serotonin acts as a vasodilator, regulates calcium dynamics. N-(p-Coumaroyl) Serotonin can be used for the research of neurodegenerative diseases, atherosclerosis, glioblastoma, and acute renal failure .
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m-Coumaric acid
m-Coumaric acid
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Cat. No.: HY-113357
CAS No.: 588-30-7
Purity:  99.84%
Category:  

Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats .
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Punicalagin (Standard)
Punicalagin (Standard)
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Cat. No.: HY-N0063R
CAS No.: 65995-63-3
Category:  

Punica granatum L. Phenols Polyphenols Punicaceae Plants

Target:  

Reference Standards SARS-CoV HBV

Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
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EGCG-4″-sulfate
EGCG-4″-sulfate
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Cat. No.: HY-150526
CAS No.: 2708237-76-5
Category:  

Flavonoids Flavanols Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Apoptosis

EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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(-)-Epigallocatechin Gallate-d4
(-)-Epigallocatechin Gallate-d4
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Cat. No.: HY-13653S1
Synonyms: EGCG-d4; Epigallocatechol Gallate-d4
(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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(±)-Catechin (Standard)
(±)-Catechin (Standard)
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Cat. No.: HY-B1890R
CAS No.: 7295-85-4
Synonyms: rel-Cianidanol (Standard); rel-Catechuic acid (Standard)
Category:  

Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Theaceae

Target:  

Reference Standards COX

(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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Glyasperin C
Glyasperin C
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Cat. No.: HY-N9919
CAS No.: 142474-53-1
Category:  

Flavonoids Leguminosae Other Diseases Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones

Target:  

Others

Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC50 of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .
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Cyanidin 3-sophoroside chloride
Cyanidin 3-sophoroside chloride
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Cat. No.: HY-129137
CAS No.: 18376-31-3
Purity:  99.6%
Synonyms: Cy 3-soph
Category:  

Rosaceae Plants Prunus cerasus L.

Target:  

Tyrosinase

Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO)/Tyrosinase inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period .
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Arbutin (Standard)
Arbutin (Standard)
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Cat. No.: HY-N0192R
CAS No.: 497-76-7
Synonyms: β-Arbutin (Standard)
Category:  

Bergenia purpurascens (Hook. f. et Thoms.) Engl. Human Gut Microbiota Metabolites Microorganisms Phenols Plants Saxifragaceae Endogenous metabolite

Target:  

Reference Standards Tyrosinase Endogenous Metabolite

Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .
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4-Methylsyringol
4-Methylsyringol
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Cat. No.: HY-W100715
CAS No.: 6638-05-7
Category:  

Davalliaceae Davallia trichomanoides Blume Plants

Target:  

Others

4-Methylsyringol is a phenolic syringol derivative found in a variety of plants. Phenolic compounds are widely present in food and plants and have high synthetic, medicinal, and industrial value. Polyphenols are compounds with various phenolic functions. Natural polyphenols can regulate the cell cycle, induce apoptosis, inhibit cell adhesion, migration, proliferation, and differentiation, and possess a variety of biological activities such as antioxidation, anti-inflammation, anticancer, and antimutagenic effects .
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