Search Result
Results for "
poorly
" in MedChemExpress (MCE) Product Catalog:
36
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-17031
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SBE-β-CD
Maximum Cited Publications
147 Publications Verification
Sulfobutylether-β-Cyclodextrin
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Biochemical Assay Reagents
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Others
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SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .
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- HY-Y1892
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Biochemical Assay Reagents
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Others
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Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.
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- HY-137234
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2,6-Di-O-methyl-β-cyclodextrin
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Biochemical Assay Reagents
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Others
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DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.
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- HY-401424
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Polyoxyethylene(36) Castor Oil; PEG-36 Castor Oil
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Environmental Pollutants
Biochemical Assay Reagents
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Others
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Cremophor EL-36 is a non-ionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). For example, Cremophor EL-36 can enhance the intracellular influx of Etoposide (HY-13629) without affecting drug efflux, and can dose-dependently increase the accumulation of VP-16 in lung adenocarcinoma cells (such as PC-14 and A549), significantly enhancing its cytotoxic effect .
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- HY-15894A
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Endothelin Receptor
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Cardiovascular Disease
Endocrinology
Cancer
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BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM .
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- HY-W250168
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Polyethylene glycol oleyl ether, average Mn～709; Polyethylene glycol monooleyl ether, n～10
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Environmental Pollutants
Biochemical Assay Reagents
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Others
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Polyoxyethylene(10) oleyl ether, also known as POE(10) monooleate, is a nonionic surfactant consisting of a polyethylene glycol chain with 10 ethylene oxide units and an oleic acid residue. It has excellent emulsifying, wetting and dispersing properties, making it suitable for a variety of applications including personal care products and pharmaceutical formulations. POE(10) monooleate is commonly used as a solubilizer to improve the solubility and bioavailability of poorly soluble drugs. Furthermore, it is biodegradable and has low toxicity, making it an environmentally friendly ingredient suitable for various industrial applications.
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- HY-W040040
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Environmental Pollutants
Endogenous Metabolite
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Metabolic Disease
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γ-Cyclodextrin is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin has good safety .
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- HY-155882
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mPEG750-NH2
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Biochemical Assay Reagents
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Cancer
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mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
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- HY-154644
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Environmental Pollutants
Biochemical Assay Reagents
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Cancer
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Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .
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- HY-15158
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- HY-P4279
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Angiotensin-converting Enzyme (ACE)
Cholinesterase (ChE)
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Cardiovascular Disease
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Ovalbumin (154-159) is a protein fragment consisting of residues 154-159 of chicken ovalbumin. Ovalbumin (154-159) is also a poorly conserved sequence (Thr-Asn-Gly-Ile-Ile-Arg) in the α-subunit of the Torpedo acetylcholine receptor, located within the α150-164 epitope region, and exhibits significant angiotensin-converting enzyme (ACE) inhibitory activity .
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- HY-13275
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IRAK
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Inflammation/Immunology
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IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
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- HY-140741
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Biochemical Assay Reagents
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Inflammation/Immunology
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DSPE-PEG2000-OH is an absorption enhancer. DSPE-PEG2000-OH reduces the expression levels of ZO-1 and Occludin. DSPE-PEG2000-OH enhances the pulmonary absorption of poorly absorbable macromolecules via the paracellular pathway without altering pulmonary membrane fluidity .
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- HY-143896
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STING
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Cancer
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STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .
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- HY-120179
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AAK1
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Neurological Disease
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LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .
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- HY-134665
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- HY-B0926B
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N-Methyl-D-glucamine diatrizoate
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Biochemical Assay Reagents
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Metabolic Disease
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Diatrizoate meglumine (N-Methyl-D-glucamine diatrizoate) is an orally active, water-soluble, poorly absorbable iodinated contrast agent. Diatrizoate meglumine is widely used as an adjuvant for radiological diagnosis and can also be applied to studies of small bowel obstruction in non-malignant conditions .
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- HY-P5492
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Delta-lysin
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Bacterial
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Others
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Delta-hemolysin (Delta-lysin), a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin is a model in the study of peptides interacting with membranes. Delta-hemolysin is poorly active against bacteria .
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- HY-P4211
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Bacterial
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Infection
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PSM-β is a active peptide , which can be isolated from Staphylococcus epidermidis. PSM-β is an analog of staphylococcal toxins, as well as a termed phenol-soluble modulin. PSM-β has bacteriostatic and poorly hemolytic properties .
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- HY-W440894
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Biochemical Assay Reagents
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Others
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DSPE-PEG5000-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-DBCO sodium can be used in drug delivery research .
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- HY-167028
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Biochemical Assay Reagents
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Others
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DSPE-PEG2000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-alkyne can be used in drug delivery research .
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- HY-W440881
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Biochemical Assay Reagents
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Others
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DSPE-PEG3400-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-DBCO sodium can be used in drug delivery research .
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- HY-114141
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Prostaglandin Receptor
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Inflammation/Immunology
Endocrinology
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BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively . BI-671800 has potential for the treatment of poorly controlled asthma .
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- HY-166979
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Biochemical Assay Reagents
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Others
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Stearic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG2000 can be used in drug delivery research .
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- HY-166968
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Biochemical Assay Reagents
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Others
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DSPE-PEG5000-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-COOH can be used in drug delivery research .
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- HY-166983
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Biochemical Assay Reagents
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Others
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m-PEG5000-DMG is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG5000-DMG can be used in drug delivery research .
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- HY-W040040A
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Endogenous Metabolite
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Metabolic Disease
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γ-Cyclodextrin hydrate is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin hydrate can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin hydrate has good safety .
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- HY-152205
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Myosin
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Others
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JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM .
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- HY-W440925
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Biochemical Assay Reagents
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Others
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m-PEG5000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG5000-DSPE sodium can be used in drug delivery research .
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- HY-144308
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Mps1
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Others
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RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region .
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- HY-166874
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Biochemical Assay Reagents
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Others
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DSPE-PEG2000-endo-BCN is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-endo-BCN can be used in drug delivery research .
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- HY-15158A
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- HY-166871
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Biochemical Assay Reagents
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Others
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DSPE-PEG5000-endo-BCN is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-endo-BCN can be used in drug delivery research .
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- HY-120179A
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AAK1
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Neurological Disease
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LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .
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- HY-155877N
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Biochemical Assay Reagents
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Others
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mPEG-DSPE (MW 5000) sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. mPEG-DSPE (MW 5000) sodium can be used in drug delivery research .
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- HY-166980
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Biochemical Assay Reagents
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Others
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m-PEG-DPPE (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DPPE (MW 2000) can be used in drug delivery research .
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- HY-W440924
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Biochemical Assay Reagents
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Others
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m-PEG3000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG3000-DSPE sodium can be used in drug delivery research .
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- HY-167028B
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Biochemical Assay Reagents
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Others
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DSPE-PEG3400-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-alkyne can be used in drug delivery research .
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- HY-W440922
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Biochemical Assay Reagents
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Others
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m-PEG1000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG1000-DSPE sodium can be used in drug delivery research .
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- HY-167022
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Biochemical Assay Reagents
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Others
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DSPE-PEG600-azide is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG600-azide can be used in drug delivery research .
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- HY-167031
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Biochemical Assay Reagents
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Others
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DOPE-PEG5000-DBCO is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DOPE-PEG5000-DBCO can be used in drug delivery research .
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- HY-166982
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Biochemical Assay Reagents
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Others
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DSPE-PEG2000-PA is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-PA can be used in drug delivery research .
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- HY-166996
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Biochemical Assay Reagents
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Others
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Bis(N-2-ethoxyethyl 2-hexyldecanoate)amine is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Bis(N-2-ethoxyethyl 2-hexyldecanoate)amine can be used in drug delivery research .
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- HY-W440881A
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Liposome
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DSPE-PEG3400-C2-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-C2-DBCO sodium can be used in drug delivery research .
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- HY-P5492A
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Delta-lysin TFA
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Bacterial
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Others
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Delta-hemolysin (Delta-lysin) TFA, a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin TFA may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin TFA is a model in the study of peptides interacting with membranes. Delta-hemolysin TFA is poorly active against bacteria .
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- HY-B1172R
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4-O-β-D-Galactopyranosyl-D-fructose (Standard)
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Reference Standards
Endogenous Metabolite
Bacterial
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Others
Cancer
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Lactulose (Standard) is the analytical standard of Lactulose. This product is intended for research and analytical applications. Lactulose (4-O-β-D-Galactopyranosyl-D-fructose) is a poorly absorbed sugar that can be used to study constipation and hepatic encephalopathy. The drug generally begins to take effect 8 to 12 hours after administration, but it may take two days to improve constipation.
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- HY-W440922A
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Biochemical Assay Reagents
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Others
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m-PEG-C1-DSPE sodium (MW 1000) is a structural analog of m-PEG-DSPE sodium (MW 1000) (HY-W440922). m-PEG-C1-DSPE sodium (MW 1000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-C1-DSPE sodium (MW 1000) can be used in drug delivery research .
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- HY-W040040R
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Reference Standards
Endogenous Metabolite
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Metabolic Disease
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γ-Cyclodextrin (Standard) is the analytical standard of γ-Cyclodextrin (HY-W040040). This product is intended for research and analytical applications. γ-Cyclodextrin is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin has good safety.
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- HY-W440932
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Biochemical Assay Reagents
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Others
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Stearic acid-mPEG5000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG5000 can be used in drug delivery research .
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- HY-W440930
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Biochemical Assay Reagents
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Others
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Stearic acid-mPEG1000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG1000 can be used in drug delivery research .
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- HY-W440942
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Biochemical Assay Reagents
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Others
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Pentacosadiynoic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG2000 can be used in drug delivery research .
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- HY-W440943
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Biochemical Assay Reagents
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Others
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Pentacosadiynoic acid-mPEG5000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG5000 can be used in drug delivery research .
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- HY-W440941
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Biochemical Assay Reagents
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Others
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Pentacosadiynoic acid-mPEG1000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG1000 can be used in drug delivery research .
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- HY-W440825
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Biochemical Assay Reagents
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Others
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DSPE-PEG1000-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG1000-COOH can be used in drug delivery research .
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- HY-166807
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Biochemical Assay Reagents
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Others
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Palmitate-PEG1000-Mal is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Palmitate-PEG1000-Mal can be used in drug delivery research .
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- HY-167028A
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Biochemical Assay Reagents
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Others
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DSPE-PEG1000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG1000-alkyne can be used in drug delivery research .
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- HY-W440830
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Biochemical Assay Reagents
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Others
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DSPE-PEG3400-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-COOH can be used in drug delivery research .
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- HY-167028C
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Biochemical Assay Reagents
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Others
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DSPE-PEG5000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-alkyne can be used in drug delivery research .
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- HY-N19827
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Biochemical Assay Reagents
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Inflammation/Immunology
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Monodesmoside saponin C is an absorption enhancer. Monodesmoside saponin C promotes the absorption of poorly absorbable β-lactam antibiotics in the small intestine and rectum of rats. Monodesmoside saponin C has the ability to chelate Ca 2+. The absorption-enhancing activity of Monodesmoside saponin C is inhibited by coexisting Ca 2+ ions. Monodesmoside saponin C can be used in studies on absorption enhancement of β-lactam antibiotics .
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- HY-N17984
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Biochemical Assay Reagents
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Others
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Hemsloside Ma3 is an anionic surfactant and solubilizer. Hemsloside Ma3 is an oleanolic acid bisdesmosidic saponin that can be isolated from the rhizomes of Hemsleya macrosperma and Hemsleya chinensis. Hemsloside Ma3 improves the water solubility of saikosaponin a, a poorly water-soluble monodesmosidic saponin, and its solubilizing effect appears near the critical micelle concentration. At a constant ionic strength, Hemsloside Ma3 exhibits the property of reduced surface tension with the increase in hydrogen ion concentration .
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- HY-182377
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Interleukin Related
TNF Receptor
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Inflammation/Immunology
Cancer
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DT-5461 is an IL-1 and TNF-α antagonist. DT-5461 competitively binds lipid A-binding sites on macrophage receptors, blocks LPS (HY-D1056)-initiated signaling, inhibits LPS-induced cytokine release, prevents LPS-induced serum cytokine production in mice, and protects against LPS-induced lethal endotoxemia. DT-5461 can be used for the research of lethal endotoxemia, medullary tubular mammary carcinoma, poorly differentiated colon adenocarcinoma, squamous-cell lung carcinoma, and gelatinous gastric adenocarcinoma .
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HY-L0120V
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170,269 compounds
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“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.
Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).
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HY-L086
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3,545 compounds
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Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.
MCE offers a unique collection of 3,545 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.
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| Cat. No. |
Product Name |
Type |
-
- HY-17031
-
SBE-β-CD
Maximum Cited Publications
147 Publications Verification
Sulfobutylether-β-Cyclodextrin
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Biochemical Assay Reagents
|
|
SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .
|
-
- HY-Y1892
-
|
|
Biochemical Assay Reagents
|
|
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.
|
-
- HY-137234
-
|
2,6-Di-O-methyl-β-cyclodextrin
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Biochemical Assay Reagents
|
|
DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.
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- HY-401424
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Polyoxyethylene(36) Castor Oil; PEG-36 Castor Oil
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Biochemical Assay Reagents
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Cremophor EL-36 is a non-ionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). For example, Cremophor EL-36 can enhance the intracellular influx of Etoposide (HY-13629) without affecting drug efflux, and can dose-dependently increase the accumulation of VP-16 in lung adenocarcinoma cells (such as PC-14 and A549), significantly enhancing its cytotoxic effect .
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- HY-W250168
-
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Polyethylene glycol oleyl ether, average Mn～709; Polyethylene glycol monooleyl ether, n～10
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Biochemical Assay Reagents
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Polyoxyethylene(10) oleyl ether, also known as POE(10) monooleate, is a nonionic surfactant consisting of a polyethylene glycol chain with 10 ethylene oxide units and an oleic acid residue. It has excellent emulsifying, wetting and dispersing properties, making it suitable for a variety of applications including personal care products and pharmaceutical formulations. POE(10) monooleate is commonly used as a solubilizer to improve the solubility and bioavailability of poorly soluble drugs. Furthermore, it is biodegradable and has low toxicity, making it an environmentally friendly ingredient suitable for various industrial applications.
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-
- HY-155882
-
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mPEG750-NH2
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Biochemical Assay Reagents
|
|
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
|
-
- HY-140741
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-OH is an absorption enhancer. DSPE-PEG2000-OH reduces the expression levels of ZO-1 and Occludin. DSPE-PEG2000-OH enhances the pulmonary absorption of poorly absorbable macromolecules via the paracellular pathway without altering pulmonary membrane fluidity .
|
-
- HY-B0926B
-
|
N-Methyl-D-glucamine diatrizoate
|
Biochemical Assay Reagents
|
|
Diatrizoate meglumine (N-Methyl-D-glucamine diatrizoate) is an orally active, water-soluble, poorly absorbable iodinated contrast agent. Diatrizoate meglumine is widely used as an adjuvant for radiological diagnosis and can also be applied to studies of small bowel obstruction in non-malignant conditions .
|
-
- HY-W440894
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-DBCO sodium can be used in drug delivery research .
|
-
- HY-167028
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-alkyne can be used in drug delivery research .
|
-
- HY-W440881
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-DBCO sodium can be used in drug delivery research .
|
-
- HY-166979
-
|
|
Biochemical Assay Reagents
|
|
Stearic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG2000 can be used in drug delivery research .
|
-
- HY-166968
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-COOH can be used in drug delivery research .
|
-
- HY-166983
-
|
|
Biochemical Assay Reagents
|
|
m-PEG5000-DMG is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG5000-DMG can be used in drug delivery research .
|
-
- HY-W040040A
-
|
|
Biochemical Assay Reagents
|
|
γ-Cyclodextrin hydrate is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin hydrate can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin hydrate has good safety .
|
-
- HY-W440925
-
|
|
Biochemical Assay Reagents
|
|
m-PEG5000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG5000-DSPE sodium can be used in drug delivery research .
|
-
- HY-166874
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-endo-BCN is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-endo-BCN can be used in drug delivery research .
|
-
- HY-166871
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-endo-BCN is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-endo-BCN can be used in drug delivery research .
|
-
- HY-166980
-
|
|
Biochemical Assay Reagents
|
|
m-PEG-DPPE (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DPPE (MW 2000) can be used in drug delivery research .
|
-
- HY-W440924
-
|
|
Biochemical Assay Reagents
|
|
m-PEG3000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG3000-DSPE sodium can be used in drug delivery research .
|
-
- HY-167028B
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-alkyne can be used in drug delivery research .
|
-
- HY-W440922
-
|
|
Biochemical Assay Reagents
|
|
m-PEG1000-DSPE sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG1000-DSPE sodium can be used in drug delivery research .
|
-
- HY-167022
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG600-azide is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG600-azide can be used in drug delivery research .
|
-
- HY-167031
-
|
|
Biochemical Assay Reagents
|
|
DOPE-PEG5000-DBCO is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DOPE-PEG5000-DBCO can be used in drug delivery research .
|
-
- HY-166982
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-PA is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG2000-PA can be used in drug delivery research .
|
-
- HY-166996
-
|
|
Biochemical Assay Reagents
|
|
Bis(N-2-ethoxyethyl 2-hexyldecanoate)amine is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Bis(N-2-ethoxyethyl 2-hexyldecanoate)amine can be used in drug delivery research .
|
-
- HY-W440932
-
|
|
Biochemical Assay Reagents
|
|
Stearic acid-mPEG5000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG5000 can be used in drug delivery research .
|
-
- HY-W440930
-
|
|
Biochemical Assay Reagents
|
|
Stearic acid-mPEG1000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Stearic acid-mPEG1000 can be used in drug delivery research .
|
-
- HY-W440942
-
|
|
Biochemical Assay Reagents
|
|
Pentacosadiynoic acid-mPEG2000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG2000 can be used in drug delivery research .
|
-
- HY-W440943
-
|
|
Biochemical Assay Reagents
|
|
Pentacosadiynoic acid-mPEG5000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG5000 can be used in drug delivery research .
|
-
- HY-W440941
-
|
|
Biochemical Assay Reagents
|
|
Pentacosadiynoic acid-mPEG1000 is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Pentacosadiynoic acid-mPEG1000 can be used in drug delivery research .
|
-
- HY-W440825
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG1000-COOH can be used in drug delivery research .
|
-
- HY-166807
-
|
|
Biochemical Assay Reagents
|
|
Palmitate-PEG1000-Mal is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Palmitate-PEG1000-Mal can be used in drug delivery research .
|
-
- HY-167028A
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG1000-alkyne can be used in drug delivery research .
|
-
- HY-W440830
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-COOH is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-COOH can be used in drug delivery research .
|
-
- HY-167028C
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-alkyne is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-alkyne can be used in drug delivery research .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P4279
-
|
|
Angiotensin-converting Enzyme (ACE)
Cholinesterase (ChE)
|
Cardiovascular Disease
|
|
Ovalbumin (154-159) is a protein fragment consisting of residues 154-159 of chicken ovalbumin. Ovalbumin (154-159) is also a poorly conserved sequence (Thr-Asn-Gly-Ile-Ile-Arg) in the α-subunit of the Torpedo acetylcholine receptor, located within the α150-164 epitope region, and exhibits significant angiotensin-converting enzyme (ACE) inhibitory activity .
|
-
- HY-P5492
-
|
Delta-lysin
|
Bacterial
|
Others
|
|
Delta-hemolysin (Delta-lysin), a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin is a model in the study of peptides interacting with membranes. Delta-hemolysin is poorly active against bacteria .
|
-
- HY-P4211
-
|
|
Bacterial
|
Infection
|
|
PSM-β is a active peptide , which can be isolated from Staphylococcus epidermidis. PSM-β is an analog of staphylococcal toxins, as well as a termed phenol-soluble modulin. PSM-β has bacteriostatic and poorly hemolytic properties .
|
-
- HY-P5492A
-
|
Delta-lysin TFA
|
Bacterial
|
Others
|
|
Delta-hemolysin (Delta-lysin) TFA, a 26 amino acid peptide, is a hemolytic peptide produced by Staphylococcus. Delta-hemolysin TFA may slightly perturb a membrane or lead to cell lysis. Delta-hemolysin TFA is a model in the study of peptides interacting with membranes. Delta-hemolysin TFA is poorly active against bacteria .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W440894
-
|
|
|
DBCO
|
|
DSPE-PEG5000-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG5000-DBCO sodium can be used in drug delivery research .
|
-
- HY-W440881
-
|
|
|
DBCO
|
|
DSPE-PEG3400-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-DBCO sodium can be used in drug delivery research .
|
-
- HY-167022
-
|
|
|
Azide
|
|
DSPE-PEG600-azide is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG600-azide can be used in drug delivery research .
|
-
- HY-167031
-
|
|
|
DBCO
|
|
DOPE-PEG5000-DBCO is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DOPE-PEG5000-DBCO can be used in drug delivery research .
|
-
- HY-W440881A
-
|
|
|
DBCO
|
|
DSPE-PEG3400-C2-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-C2-DBCO sodium can be used in drug delivery research .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W040040
-
|
|
|
Emulsifiers
Chelating Agents
Solubilizing Agents
|
|
γ-Cyclodextrin is an orally active cyclic oligosaccharide composed of eight glucose molecules, which can be formed by bacteria digesting starch. γ-Cyclodextrin can form water-soluble inclusion complexes with a variety of poorly soluble compounds and is widely used in fields such as pharmacy and food. In addition, γ-Cyclodextrin has good safety .
|
-
- HY-155882
-
|
mPEG750-NH2
|
|
Polymers
|
|
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
|
-
- HY-154644
-
|
|
|
Emulsifiers
Solubilizing Agents
|
|
Soya Lecithin is a phospholipid mixture that can be used as a drug delivery vehicle and is a pharmaceutical excipient. Soya Lecithin can form a lipid bilayer structure through self-assembly, and its binding properties are amphiphilic (hydrophilic head and hydrophobic tail), encapsulating hydrophobic drugs. Soya Lecithin forms stable nanoliposomes or microemulsions, improves the solubility and cellular uptake efficiency of poorly soluble drugs (such as Curcumin (HY-N0005)), and exerts activities such as enhancing drug delivery and regulating cell proliferation .
|
-
- HY-140741
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG2000-OH is an absorption enhancer. DSPE-PEG2000-OH reduces the expression levels of ZO-1 and Occludin. DSPE-PEG2000-OH enhances the pulmonary absorption of poorly absorbable macromolecules via the paracellular pathway without altering pulmonary membrane fluidity .
|
-
- HY-W440881
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG3400-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-DBCO sodium can be used in drug delivery research .
|
-
- HY-166983
-
|
|
|
Pegylated Lipids
|
|
m-PEG5000-DMG is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG5000-DMG can be used in drug delivery research .
|
-
- HY-155877N
-
|
|
|
Pegylated Lipids
|
|
mPEG-DSPE (MW 5000) sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. mPEG-DSPE (MW 5000) sodium can be used in drug delivery research .
|
-
- HY-166980
-
|
|
|
Pegylated Lipids
|
|
m-PEG-DPPE (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. m-PEG-DPPE (MW 2000) can be used in drug delivery research .
|
-
- HY-167031
-
|
|
|
Pegylated Lipids
|
|
DOPE-PEG5000-DBCO is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DOPE-PEG5000-DBCO can be used in drug delivery research .
|
-
- HY-W440881A
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG3400-C2-DBCO sodium is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG3400-C2-DBCO sodium can be used in drug delivery research .
|
-
- HY-166807
-
|
|
|
Pegylated Lipids
|
|
Palmitate-PEG1000-Mal is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. Palmitate-PEG1000-Mal can be used in drug delivery research .
|
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