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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
proliferating cell nuclear antigen
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "proliferating cell nuclear antigen" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
2
2 Cited Publications
Cat. No.: HY-P4322
CAS No.: 131167-89-0
Research Areas:
1
1 Cited Publications
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AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis .
1
1 Cited Publications
Cat. No.: HY-P73729
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCNA; Truncated proliferating cell nuclear antigen; proliferating cell nuclear antigen; DNA Polymerase Delta Auxiliary Protein; DNA Sliding Clamp PCNA; ATLD2; Cyclin
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W010128
CAS No.: 938-55-6
Synonyms: 6-Dimethylaminopurine; 6-DMAP
Category:
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PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41μM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors .
Cat. No.: HY-19167
CAS No.: 136892-64-3
Synonyms: AS 013; Lipo-pro-prostaglandin E1
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Research Areas:
Ecraprost is a prodrug of prostaglandin E1. Ecraprost inhibits platelet adhesion, macrophage infiltration and proliferating cell nuclear antigen positive cell expression on the injured arterial walls .
Cat. No.: HY-P10825
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Cat. No.: HY-W010128R
CAS No.: 938-55-6
Synonyms: 6-Dimethylaminopurine (Standard); 6-DMAP (Standard)
Research Areas:
6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis) .
Cat. No.: HY-163691
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Research Areas:
Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) targeting carbonic anhydrase IX (CAIX). Antitumor agent-163 inactivates CAIX protein via singlet oxygen under 540 nm wavelength light, without affecting internal standard proteins such as α-tubulin, β-actin, and proliferating cell nuclear antigen (PCNA). Antitumor agent-163 induces cell membrane damage, inhibits cell viability (IC50 is 0.2 and 0.05 μM for A549 and U87MG). Antitumor agent-163 exhibits antitumor efficacy in mouse model .
Cat. No.: HY-P86690
Synonyms: Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; Mutagen-sensitive 209 protein; Pcna/cyclin; PCNAR; Polymerase delta accessory protein; proliferating cell nuclear antigen
Cat. No.: HY-P86534
Synonyms: ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; MGC8367; Mutagen-sensitive 209 protein; OTTHUMP00000030189; OTTHUMP00000030190; PCNA; Pcna/cyclin; PCNA_HUMAN; PCNAR; Polymerase delta accessory protein; proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03
Cat. No.: HY-110111R
CAS No.: 1380782-27-3
Target:
Research Areas:
T2AA (Standard) is the analytical standard of T2AA (HY-110111). This product is intended for research and analytical applications. T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
Cat. No.: HY-183488
CAS No.: 1207092-73-6
Synonyms: RRRRRRRRRCCLGIPEQEY
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
