Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
197 Results for "
protein phosphatase 1
" in MedChemExpress (MCE) Product Catalog:
Products (197)
197 Results for "protein phosphatase 1" in MCE Product Catalog:
20
Target:
Research Areas:
Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively .
9
Target:
Research Areas:
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .
9
9 Cited Publications
Target:
Research Areas:
NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) . NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .
8
8 Cited Publications
Synonyms: Trodusquemine lactate; Aminosterol-1436 lactate
Target:
Research Areas:
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).
6
6 Cited Publications
Cat. No.: HY-N0374
CAS No.: 144506-14-9
Category:
Flavonoids Chalcones Leguminosae Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch.
Target:
5
Category:
other families Flavonoids Flavonones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
Target:
5
5 Cited Publications
Target:
Research Areas:
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
3
3 Cited Publications
Target:
Research Areas:
CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy .
2
Research Areas:
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .
2
2 Cited Publications
Target:
Research Areas:
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
2
2 Cited Publications
Target:
Research Areas:
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .
2
1
1 Cited Publications
Cat. No.: HY-N2451
CAS No.: 33037-46-6
Category:
Quinones Liliaceae Monophenols Anthraquinones Metabolic Disease Aloe vera (L.) Burm. f. Phenols Plants Disease Research Fields
Target:
1
Target:
Research Areas:
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase .
1
1 Cited Publications
Cat. No.: HY-P80645
Synonyms: DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; protein-tyrosine phosphatase CL100
1
1 Cited Publications
Cat. No.: HY-P80460
Synonyms: FAK, FAK1, PTK2, Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, protein phosphatase 1 regulatory subunit 71, protein-tyrosine kinase 2, p125FAK, pp125FAK, FRNK, PPP1R71
1
1 Cited Publications
Cat. No.: HY-P75979
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPM1A; protein phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform; protein phosphatase, Mg2+/Mn2+ Dependent 1A; protein phosphatase, Mg2+/Mn2+ Dependent, 1A; protein phosphatase 1A; protein phosphatase 2C, Alpha Isoform; PP2Calpha; Alternati
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P71141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTPN6; protein-Tyrosine phosphatase SHP-1; protein Tyrosine phosphatase Non-Receptor Type 6; protein-Tyrosine phosphatase 1C; PTP-1C; SH-PTP1; HCP; Tyrosine-protein phosphatase Non-Receptor Type; SHP-1; Hematopoietic Cell phosphatase; HCPH; protein-Tyrosi
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73685
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTPN1; protein-Tyrosine phosphatase 1B; Prev. PTP1B; protein Tyrosine phosphatase, Placental; Tyrosine-protein phosphatase Non-Receptor Type 1; PTP-1B; protein Tyrosine phosphatase Non-Receptor Type 1; Tyrosine-protein phosphatase Non-Receptor Type
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P7537
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BCL2; protein phosphatase 1, Regulatory Subunit 50; BCL2 Apoptosis Regulator; B-Cell CLL/Lymphoma 2; Apoptosis Regulator Bcl-2; BCL2, Apoptosis Regulator; PPP1R50; BCL2 protein; Bcl-2
Species:
Human
Source:
E. coli
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
