sagging

By Targets:	Atg8/LC3 (1) Biochemical Assay Reagents (1) DAGL (2) DGK (1) Fluorescent Dye (1) Gli (1) HBV (1) HCN Channel (1) Hedgehog (1) Interleukin Related (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) Smo (8)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12848

*SAG* Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848B

SAG hydrochloride Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-B0633C

Hyaluronic acid (Mw:1000-2000Da)	Biochemical Assay Reagents Interleukin Related Atg8/LC3	Inflammation/Immunology
Hyaluronic acid (Mw: 1000-2000 Da) is a long-chain unbranched polysaccharide with a molecular weight of 1000-2000 Da. Hyaluronic acid (Mw: 2000 Da) inhibits IL-1β expression and increases LC3-II. Hyaluronic acid (Mw: 1000-2000Da) can regulate tissue homeostasis and stress resistance, promote angiogenesis and tissue remodeling. Hyaluronic acid (Mw: 1000-2000 Da) has good biocompatibility and biodegradability, and can be used in drug delivery systems and tissue engineering. Hyaluronic acid (Mw: 2000 Da) can reduce facial skin blemishes and sagging .

HY-12848C

SAG dihydrochloride Maximum Cited Publications 37 Publications Verification	Smo	Cancer
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-124899

Hh-Ag1.5 1 Publications Verification SAg1.5	Hedgehog	Metabolic Disease
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC₅₀ of 1 nM . Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure .

HY-117771

DO34 5 Publications Verification	DAGL	Neurological Disease Metabolic Disease
DO34 is a selective DAGL inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB₁ receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation .

HY-157993

SAG-524	HBV	Infection
SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC₅₀ 0.92 and 1.4 nM, respectively .

HY-163455

pan-HCN-IN-1	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-12848R

SAG (Standard)	Smo Reference Standards	Cancer
SAG (Standard) is the analytical standard of SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-12848G

SAG	Smo	Cancer
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-117771A

DO34 analog	DAGL	Neurological Disease Metabolic Disease
DO34 analog is a structural analog of DO34 (HY-117771). DO34 is a selective DAGL inhibitor, with an IC₅₀ of 6 nM for DAGLα conversion of SAG to 2-AG. DO34 can be used for the research of energy balance disorder and neuroinflammation .

HY-12848A

(Rac)-SAG	Smo	Cancer
(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-110240

IHR-1	Smo	Others
IHR-1 is a cell membrane impermeable Smo antagonist .

HY-12848S

SAG-d3	Smo	Cancer
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; Kd=59 nM) .

HY-RS12415

SAG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SAG Human Pre-designed siRNA Set A contains three designed siRNAs for SAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SAG Human Pre-designed siRNA Set A SAG Human Pre-designed siRNA Set A

HY-RS16512

Sag Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sag Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sag Mouse Pre-designed siRNA Set A Sag Mouse Pre-designed siRNA Set A

HY-N15152

Isoaesculioside D	Others	Metabolic Disease
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

HY-182641

SAG analog (cis-isomer) SAG-Cl (cis-isomer)	Gli	Cardiovascular Disease
SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic .

HY-RS22944

Sag Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sag Rat Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sag Rat Pre-designed siRNA Set A Sag Rat Pre-designed siRNA Set A

HY-D3314

1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol NBD-SAG	Fluorescent Dye DGK	Others
1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol (NBD-SAG) is a fluorescently labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol (HY-131897). 1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol acts as a fluorescent probe for the measurement of DGKε enzymatic activity .

Cat. No.	Product Name	Type

HY-12848G

SAG	Fluorescent Dyes
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

HY-D3314

1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol NBD-SAG	Fluorescent Dyes
1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol (NBD-SAG) is a fluorescently labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol (HY-131897). 1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol acts as a fluorescent probe for the measurement of DGKε enzymatic activity .

Cat. No.	Product Name	Type

HY-12848G

SAG	Biochemical Assay Reagents
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

Cat. No.	Product Name	Target	Research Area

HY-134017

Acetyl dipeptide-1 cetyl ester Calmosensine	Peptides	Others
Acetyl dipeptide-1 cetyl ester (Calmosensine) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15152

Isoaesculioside D	Triterpenes Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Others
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

Cat. No.	Product Name	Chemical Structure

HY-12848S

SAG-d3
SAG-d₃ is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; Kd=59 nM) .

Cat. No.	Product Name		Classification

HY-RS12415

SAG Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SAG Human Pre-designed siRNA Set A contains three designed siRNAs for SAG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16512

Sag Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sag Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22944

Sag Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sag Rat Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12848G

SAG	Smo	Cancer
SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo .

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Remarks

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

sagging

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Natural
Products