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secretory phospholipase A2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phospholipase (21) Apoptosis (2) COX (2) Endogenous Metabolite (1) HDAC (2) Interleukin Related (2) Isotope-Labeled Compounds (1) LDLR (1) Mucin (1) Reference Standards (5)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (19) Metabolic Disease (1) Neurological Disease (2)

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Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Phospholipase PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13402

Varespladib Maximum Cited Publications 9 Publications Verification LY315920	Phospholipase	Inflammation/Immunology
Varespladib (LY315920) is a potent and selective *group IIA, secretory* phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀**s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-N7036

Rhamnetin 1 Publications Verification	Phospholipase HDAC Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-17448

Varespladib methyl 1 Publications Verification A-002; LY333013	Phospholipase	Inflammation/Immunology
Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).

HY-11059

KH064	Phospholipase	Inflammation/Immunology
KH064, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 29 nM for human nonpancreatic secretory PLA₂ isoform IIa (hnpsPLA₂-IIa). KH064 has anti-inflammatory activity .

HY-P99505

Ziltivekimab COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216	Interleukin Related LDLR	Inflammation/Immunology Endocrinology
Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease .

HY-NP159

House Dust Mite Extract, from D.farinae	Mucin Interleukin Related	Inflammation/Immunology
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-107393

LY-311727	Phospholipase	Inflammation/Immunology
LY-311727 is a potent secretory non-pancreatic phospholipase A₂ (sPLA₂) inhibitor (IC₅₀ <1 μM for group IIA sPLA₂). sPLA₂ is an important proinflammatory enzyme .

HY-13402A

Varespladib sodium Maximum Cited Publications 9 Publications Verification LY315920 sodium	Phospholipase	Inflammation/Immunology
Varespladib sodium (LY315920 sodium) is a potent and selective *group IIA, secretory* phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀**s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-17485

Alminoprofen 1 Publications Verification EB-382	Phospholipase COX	Inflammation/Immunology
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and COX-2 .

HY-120078

AZD2716	Phospholipase
AZD2716 is a selective sPLA₂ (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA₂-IIa (IC₅₀ = 10 nM), sPLA₂-V (IC₅₀ = 40 nM), and sPLA₂-X (IC₅₀ = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA₂ .

HY-168765

LY433771 LSN433771	Phospholipase	Cardiovascular Disease
LY433771 (LSN433771) (Compound 8) is a type X secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ value of 3 nM, which can be used in the study of cardiovascular diseases .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Reference Standards Phospholipase	Inflammation/Immunology
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-13402S

Varespladib-d7 LY315920-d₇	Isotope-Labeled Compounds Phospholipase	Inflammation/Immunology
Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-108132

Ro 23-9358	Phospholipase	Inflammation/Immunology
Ro 23-9358 is a potent secretory *phospholipase* A2 inhibitor with anti-inflammatory activity .

HY-N7036R

Rhamnetin (Standard)	Reference Standards Phospholipase HDAC Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-17485R

Alminoprofen (Standard) EB-382 (Standard)	Reference Standards Phospholipase COX	Inflammation/Immunology
Alminoprofen (Standard) is the analytical standard of Alminoprofen. This product is intended for research and analytical applications. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and COX-2 .

HY-182680

Manoalogue	Phospholipase	Inflammation/Immunology
Manoalogue is an irreversible secretory phospholipase A2 (sPLA2) inhibitor. Manoalogue covalently modifies K94 of *bee venom phospholipase* A2 (bvPLA2)** to inactivate the enzyme and shows selective inhibition on bvPLA2. Manoalogue can suppress PLA2-mediated contractions of guinea pig lung pleural strips. Manoalogue is used for sPLA2 mechanism and respiratory physiology research .

HY-13402AR

Varespladib sodium (Standard) LY315920 sodium (Standard)	Phospholipase Reference Standards	Inflammation/Immunology
Varespladib (sodium) (Standard) is the analytical standard of Varespladib (sodium). This product is intended for research and analytical applications. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-13402R

Varespladib (Standard) LY315920 (Standard)	Phospholipase Reference Standards	Inflammation/Immunology
Varespladib (Standard) is the analytical standard of Varespladib. This product is intended for research and analytical applications. Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-133233

Thioetheramide-PC 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine	Endogenous Metabolite Phospholipase	Metabolic Disease
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a structurally modified phospholipid that acts as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). Thioetheramide-PC has an IC₅₀ value of 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, Thioetheramide-PC also binds to the activation site of the enzyme. Thioetheramide-PC binds more tightly to the activation site than to the catalytic site. As a result of this dual interaction, at low concentrations, Thioetheramide-PC may activate phospholipase activity rather than inhibit it.

HY-158792

GK241	Others	Others
GK241 (compound 31a-c) is a 2-oxoamide-based compound that has inhibitory activity against human and mouse group IIA secretory phospholipase A2 (GIIA sPLA2) (IC₅₀ of 143 nM and 68 nM, respectively), and its inhibitory mechanism was studied by molecular dynamics simulation.

HY-184012

BAY-163	Phospholipase	Endocrinology
BAY-163 is a tertiary urea derivative and inactive negative control probe for BAY-439 (HY-178123). BAY-163 does not inhibit phospholipase A2 group V (PLA2-G5) activity in immune cells. BAY-163 can be used for research on endometriosis .

Cat. No.	Product Name	Type

HY-NP159

House Dust Mite Extract, from D.farinae	Biochemical Assay Reagents
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

House Dust Mite Extract, from D.farinae

Biochemical Assay Reagents

House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99505

Ziltivekimab COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216	Interleukin Related LDLR	Inflammation/Immunology Endocrinology
Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-136177

Tris(2,4-di-tert-butylphenyl)phosphate	Natural Products Verbenaceae Plants Inflammation/Immunology Disease Research Fields Source Classification Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

HY-N7036

Rhamnetin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification	Phospholipase HDAC Apoptosis
Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

HY-N7327

Ochnaflavone	Structural Classification Flavonoids Ochna atropurpurea DC. Plants Biflavones Source Classification	Phospholipase
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-136177R

Tris(2,4-di-tert-butylphenyl)phosphate (Standard)	Natural Products Verbenaceae Plants Source Classification Vitex negundo Linn.	Reference Standards Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-N7036R

Rhamnetin (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Amberboa moschata (L.) DC. Umbelliferae Plants Source Classification	Reference Standards Phospholipase HDAC Apoptosis
Rhamnetin (Standard) is the analytical standard of Rhamnetin. This product is intended for research and analytical applications. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity .

Species:	Human (1) Mouse (2)
Tag:	SUMO (1) His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77138

	PLA2G2E Protein, Mouse (HEK293, His) Group IIE secretory phospholipase A2; GIIE sPLA2	Mouse	HEK293
	The PLA2G2E protein is a secreted calcium-dependent phospholipase A2 that targets extracellular phospholipids. It hydrolyzes the fatty acyl group at the sn-2 position, releasing unsaturated fatty acids, especially lysophosphatidylethanolamine. PLA2G2E Protein, Mouse (HEK293, His) is the recombinant mouse-derived PLA2G2E protein, expressed by HEK293 , with C-His labeled tag.

HY-P71653

	PLA2G2D Protein, Human (His-SUMO) 2IID; EC 3.1.1.4; GIID sPLA2; Group IID secretory phospholipase A2; phospholipase A2 group IID ; PlA2g2d; PLA2IID; stroma-associated homolog	Human	E. coli
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions.It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol.PLA2G2D Protein, Human (His-SUMO) is the recombinant human-derived PLA2G2D protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

HY-P76549

	PLA2G2D Protein, Mouse (HEK293, Fc) Group IID secretory phospholipase A2; GIID sPLA2; PLA2IID; Splash	Mouse	HEK293
	PLA2G2D protein is a secreted calcium-dependent phospholipase A2 that targets extracellular lipids and has anti-inflammatory and immunosuppressive functions.It hydrolyzes the fatty acyl group at the sn-2 position, preferentially hydrolyzing phosphatidylethanolamine and phosphatidylglycerol.PLA2G2D Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PLA2G2D protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-13402S

Varespladib-d7
Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

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secretory phospholipase A2

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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