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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
weakness
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "weakness" in MCE Product Catalog:
5
5 Cited Publications
Target:
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness .
3
3 Cited Publications
Cat. No.: HY-P99355
CAS No.: 1356922-05-8
Synonyms: Anti-ACVR2B Reference Antibody; BYM338
Target:
Research Areas:
Bimagrumab (Anti-ACVR2B Reference Antibody; BYM338) is a monoclonal antibody targeting activin type II receptors (ActRII). Bimagrumab binds to human ActRIIB (Kd 1.7 pM) and ActRIIA (Kd 434 pM), blocks ligand binding and downstream Smad activation, and inhibits myostatin/activin A-induced Smad phosphorylation. Bimagrumab induces skeletal muscle hypertrophy in an Akt-independent manner via mTOR-mediated muscle protein synthesis, increases muscle mass and strength, promotes myoblast differentiation/fusion, prevents myotube atrophy and glucocorticoid-induced muscle loss, reduces fat mass and fat depot weight/adipocyte size, inhibits adipose inflammation, induces fat oxidation, preserves lean body mass during incretin-induced weight loss, and enhances the appetite-suppressive effect of incretins. Bimagrumab can be used in research on obesity and skeletal muscle atrophy and weakness .
2
2
Cat. No.: HY-W011602
CAS No.: 77-93-0
Target:
Research Areas:
Triethyl citrate is an orally active citrate compound. Triethyl citrate induces acute toxic effects, including weakness, depression, ataxia, hyperexcitability, restlessness, dripping urine, and irregular, labored breathing. Triethyl citrate can be used in research on plasticizers for food packaging materials .
Synonyms: NMD670
Target:
Research Areas:
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue .
Cat. No.: HY-W011602R
CAS No.: 77-93-0
Research Areas:
Triethyl citrate (Standard) is the analytical standard of Triethyl citrate (HY-W011602). This product is intended for research and analytical applications. Triethyl citrate is an orally active citrate compound. Triethyl citrate induces acute toxic effects, including weakness, depression, ataxia, hyperexcitability, restlessness, dripping urine, and irregular, labored breathing. Triethyl citrate can be used in research on plasticizers for food packaging materials .
Cat. No.: HY-114081A
CAS No.: 18997-39-2
Synonyms: HC-3 chloride
Target:
Research Areas:
Hemicholinium chloride (HC-3) is a choline kinase (ChoK) inhibitor. Hemicholinium chloride Hemicholinium chloride induces ataxia and muscular weakness .
Category:
Alkaloids Plant Other Diseases Menispermaceae Extract Phenols Polyphenols Cissampelos pareira Extract Disease Research Fields Isoquinoline Alkaloids
Target:
Cat. No.: HY-N2522R
CAS No.: 33286-30-5
Synonyms: Gummiferin dipotassium (Standard)
Category:
Cat. No.: HY-182773
Target:
Research Areas:
MC4R Antagonist-1 (compound 1) is an MC4R-selective antagonist (IC50<10 nM). MC4R Antagonist-1 can be used for the research of cachexia, anorexia, anorexia nervosa, involuntary weight loss, failure to thrive, sarcopenia, muscle wasting, muscle weakness, frailty, osteoporosis .
Cat. No.: HY-N6609B
CAS No.: 75413-87-5
Category:
Alkaloids Plant Tiliacora racemosa Colebr. Extract Menispermaceae Extract Isoquinoline Alkaloids
Target:
Cat. No.: HY-P99355A
Synonyms: Anti-ACVR2B Reference Antibody (LALA); BYM338 (LALA)
Target:
Research Areas:
Bimagrumab (LALA) (Anti-ACVR2B Reference Antibody (LALA); BYM338 (LALA)) is a monoclonal antibody targeting activin type II receptors (ActRII). Bimagrumab (LALA) binds to human ActRIIB (Kd 1.7 pM) and ActRIIA (Kd 434 pM), blocks ligand binding and downstream Smad activation, and inhibits myostatin/activin A-induced Smad phosphorylation. The Fc region of Bimagrumab (LALA) incorporates L234A and L235A mutations, which are designed to reduce the antibody's binding to FcγR and C1q, thereby attenuating or eliminating its ADCC (antibody-dependent cell-mediated cytotoxicity) and CDC (complement-dependent cytotoxicity) effector functions. Bimagrumab (LALA) induces skeletal muscle hypertrophy in an Akt-independent manner via mTOR-mediated muscle protein synthesis, increases muscle mass and strength, promotes myoblast differentiation/fusion, prevents myotube atrophy and glucocorticoid-induced muscle loss, reduces fat mass and fat depot weight/adipocyte size, inhibits adipose inflammation, induces fat oxidation, preserves lean body mass during incretin-induced weight loss, and enhances the appetite-suppressive effect of incretins. Bimagrumab (LALA) can be used in research on obesity and skeletal muscle atrophy and weakness .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
