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xerosis ,skin

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0543

Allantoin 2 Publications Verification 5-Ureidohydantoin	Environmental Pollutants Endogenous Metabolite Imidazoline Receptor	Inflammation/Immunology Cancer
Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-W009326

Laurocapram 1 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Infection
Laurocapram is a chemical penetration enhancer that increases the permeability of compounds through the skin and mucous membranes, thereby improving their local or systemic efficacy. Laurocapram improves the skin permeability of a variety of hydrophilic and lipophilic compounds .

HY-W015967

Glycolic acid 1 Publications Verification Hydroxyethanoic acid	Environmental Pollutants Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y1365L

*Porcine skin* Gelatin,suitable for cell culture(high gel strength)**	Biochemical Assay Reagents	Others
Porcine skin Gelatin,suitable for cell culture(high gel strength) can be used to coat cells to improve cell attachment .

HY-B2170A

Octenidine dihydrochloride 3 Publications Verification	Bacterial	Infection
Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.

HY-113008

Urocanic acid 2 Publications Verification	Endogenous Metabolite	Cancer
Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).

HY-P10533

Cysteine peptide	Tyrosinase	Others
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

HY-108036

Pro-xylane (30% in water) Hydroxypropyl tetrahydropyrantriol (30% in water)	Biochemical Assay Reagents	Metabolic Disease
Pro-xylane (30% in water) (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane (30% in water) stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane (30% in water) can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane (30% in water) is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane (30% in water) is eco-friendly and biodegradable .

HY-111940

LUT014	Raf p38 MAPK ERK	Inflammation/Immunology
LUT014 is a topical inhibitor targeting BRAF that cannot pass through the blood-brain barrier. LUT014 inhibits BRAF kinase and abnormally activates the MAPK/ERK signaling pathway, promoting the proliferation of epidermal keratinocytes, repairing skin barrier damage caused by radiation damage, and alleviating inflammatory responses. LUT014 is independent of RAS signaling and accelerates the repair and regeneration of damaged skin cells. LUT014 can be used to study radiation dermatitis, especially skin damage caused by breast cancer radiotherapy .

HY-126573

Trilaurin	Endogenous Metabolite Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease Cancer
Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics .

HY-N1416

Pogostone 2 Publications Verification	Bacterial Apoptosis Autophagy	Infection Inflammation/Immunology Cancer
Pogostone is isolated from patchouli oil with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy .

HY-NP175

*Collagen (bovine skin)*	Biochemical Assay Reagents Integrin Discoidin Domain Receptor	Others
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development .

HY-125809

4-(1-Phenylethyl)resorcinol	Biochemical Assay Reagents	Others
4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.

HY-N7132

(-)-Menthyl acetate L-Menthyl acetate	Biochemical Assay Reagents Drug Derivative	Others
(-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .

HY-P5225

Acetyl hexapeptide-38	PGC-1α	Others
Acetyl hexapeptide-38 is a tissue repair promoter that targets fibroblasts in the dermis of the skin. It works by promoting collagen synthesis in the dermis and thickening of subcutaneous fat. Acetyl hexapeptide-38 can activate the skin repair mechanism, increase the collagen content in the dermis, improve the skin tissue structure, and has the activity of promoting local tissue repair. Acetyl hexapeptide-38 can be used in the field of cosmetic medicine to repair congenital soft tissue defects, reduce tear grooves and nasolabial folds, eliminate postoperative scars, and conduct micro-plastic surgery of skin tissue .

HY-108036B

Pro-xylane Hydroxypropyl tetrahydropyrantriol	Biochemical Assay Reagents	Metabolic Disease
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane is eco-friendly and biodegradable .

HY-N0543S

Allantoin-13C2,15N4 5-Ureidohydantoin-¹³C₂,¹⁵N₄	Imidazoline Receptor Endogenous Metabolite	Cancer
Allantoin- ¹³C₂, ¹⁵N₄ is the ¹³C and ¹⁵N labeled Allantoin . Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Others	Cardiovascular Disease Inflammation/Immunology
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-P0095

Acetyl tetrapeptide-5	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-B0485

Fluocinonide	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.

HY-130187A

Sapienic acid sodium 1 Publications Verification	Bacterial	Infection
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against *Streptococcus sanguinis, Streptococcus mitis* and *Fusobacterium nucleatum* with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

HY-Y1365E

*Porcine skin* Gelatin,suitable for cell culture(medium gel strength)**	Biochemical Assay Reagents	Others
Porcine skin Gelatin, suitable for cell culture (medium gel strength) can be used to coat cells to improve cell attachment .

HY-P0104

Palmitoyl tripeptide-38	Collagen	Metabolic Disease
Palmitoyl tripeptide-38 is a lipopeptide that increases the production of dermal and epidermal collagen, fibronectin, and hyaluronic acid. Palmitoyl tripeptide-38 is used in research related to skin aging (fine lines, wrinkles, reduced skin elasticity, decreased skin water content, uneven skin tone) .

HY-Y1106

Tripotassium phosphate	Environmental Pollutants Biochemical Assay Reagents Bacterial	Infection
Tripotassium phosphate is a Bactericid with bactericidal activity primarily against Gram-negative bacteria. Tripotassium phosphate reduces the population counts of Enterobacteriaceae and Campylobacter in poultry skin rinsates. Tripotassium phosphate fails to reduce the population count of Enterococcus in poultry skin rinsates .

HY-108036A

(S)-Pro-xylane (S)-Hydroxypropyl tetrahydropyrantriol	Biochemical Assay Reagents	Metabolic Disease
(S)-Pro-xylane ((S)-Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. (S)-Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. (S)-Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. (S)-Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. (S)-Pro-xylane is eco-friendly and biodegradable .

HY-17570

Desoximetasone 1 Publications Verification	Glucocorticoid Receptor Interleukin Related Cytochrome P450	Inflammation/Immunology
Desoximetasone is a corticosteroid and a substrate of cytochrome P450 3A4. Desoximetasone has anti-inflammatory, anti-allergic, and immunosuppressive effects. Desoximetasone can be used in the research of various skin diseases, such as skin allergies, atopic dermatitis, and psoriasis .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-U00058

Diflucortolone valerate	Fungal Bacterial	Infection Inflammation/Immunology
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .

HY-B1013

Flurandrenolide 1 Publications Verification Fludroxycortide; Flurandrenolone	Glucocorticoid Receptor	Inflammation/Immunology
Fludroxycortide is a synthetic topical steroid with anti-inflammatory effects and has potential for use in skin irritation.

HY-141579

Sphingosine (d17:1)	Others	Neurological Disease
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin .

HY-B1530

Ammonium lactate (60%w/w in water) 35+ Cited Publications (±)-Ammonium lactate	Environmental Pollutants Bacterial	Infection
Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis .

HY-B1555

Benzyl nicotinate	Liposome	Cardiovascular Disease
Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow .

HY-N10496

Sericoside	Others	Inflammation/Immunology
Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .

HY-Y1129

3-Hydroxypyridine	Photosensitizer Apoptosis	Inflammation/Immunology
3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .

HY-Y0683A

Petrolatum (white)	Biochemical Assay Reagents	Infection Inflammation/Immunology
Petrolatum (white) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (white) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (white) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (white) is used in research on atopic dermatitis and post-operative skin infections .

HY-W040996

2-Octyldodecanol	Environmental Pollutants	Others
2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .

HY-Y1809

1-Hydroxyoctadecane Stearyl alcohol	Environmental Pollutants Biochemical Assay Reagents	Inflammation/Immunology
1-Hydroxyoctadecane (Stearyl alcohol) is a long-chain fatty alcohol and excipient. 1-Hydroxyoctadecane forms a closed oil film, thereby reducing transepidermal water loss (TEWL) and promoting skin moisturization. 1-Hydroxyoctadecane improves Imiquimod (HY-B0180)-induced psoriatic skin inflammation in mice .

HY-NP101

Highly purified Type I collagen, from bovine skin 1 Publications Verification Bovine Type I collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

HY-NP109

Highly purified type I collagen, from mouse skin Mouse Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-N0543R

Allantoin (Standard) 5-Ureidohydantoin (Standard)	Reference Standards Imidazoline Receptor Endogenous Metabolite	Inflammation/Immunology Cancer
Allantoin (Standard) is the analytical standard of Allantoin. This product is intended for research and analytical applications. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-W250145

Acid Black 2 Nigrosine	Biochemical Assay Reagents	Others
Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin .

HY-P5237

Tetrapeptide-4	Collagen	Others
Tetrapeptide-4 is a synthetic tetrapeptide. Tetrapeptide-4 upregulates hyaluronic acid synthetase, and collagen production in human dermal fibroblasts. Tetrapeptide-4 reduces skin aging, improves skin firmness, elasticity, and appearance, and benefits hair .

HY-132818

Idrevloride P-1037	Sodium Channel	Others
Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .

HY-130187

Sapienic acid 1 Publications Verification	Bacterial	Infection
Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against *Streptococcus sanguinis, Streptococcus mitis* and *Fusobacterium nucleatum* with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Biochemical Assay Reagents	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

HY-164066

Sodium Acetylated Hyaluronate	Biochemical Assay Reagents	Others
Sodium Acetylated Hyaluronate is an acetylated hyaluronic acid derivative with anti-wrinkle and deep skin penetration properties, which can be used in skin aging research and cosmetic development .

HY-W591838

Perfluoropentanesulfonic acid PFPeS	Biochemical Assay Reagents Phosphatase	Metabolic Disease
Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin .

HY-W009051

Decamethylcyclopentasiloxane	Environmental Pollutants Biochemical Assay Reagents	Others
Decamethylcyclopentasiloxane (D5), an organosilicon compound that is used as a skin emollient in cosmetics and personal products .

HY-NP103

Highly purified Type III collagen, from bovine skin Bovine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-106647

Abacavir hydroxyacetate	Interleukin Related	Inflammation/Immunology
Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0776

Isorhamnetin 15+ Cited Publications 3'-Methylquercetin	Cardiovascular Disease Flavonols Classification of Application Fields Hippophaë rhamnoides Plants Endogenous metabolite Flavonoids Microorganisms Leguminosae Elaeagnaceae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	MEK PI3K Endogenous Metabolite
Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

HY-W020044

DL-alpha-Tocopherol 5+ Cited Publications DL-α-Tocopherol	Structural Classification Duchesnea indica (Andr.) Focke Monophenols Classification of Application Fields Rosaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Environmental Pollutants Ferroptosis Apoptosis DNA/RNA Synthesis
DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-N0543

Allantoin 2 Publications Verification 5-Ureidohydantoin	Structural Classification Natural Products Classification of Application Fields Anti-aging Disease markers Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Imidazoline Receptor
Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-N0880

Cinobufotalin 5+ Cited Publications	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Others
Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent .

HY-119358

Traumatic Acid 3 Publications Verification	Microorganisms Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Plants Phytohormone Phaseolus vulgaris Linn. Inflammation/Immunology Disease Research Fields Cytokinin Source Classification Agricultural Research	Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-B1183

Hydrocortisone acetate 1 Publications Verification Hydrocortisone 21-acetate; Cortisol 21-acetate	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids .

HY-W015967

Glycolic acid 1 Publications Verification Hydroxyethanoic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Environmental Pollutants Endogenous Metabolite Tyrosinase
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-113008

Urocanic acid 2 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).

HY-W010098

Terephthalic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields	Drug Intermediate
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .

HY-126573

Trilaurin	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification Cancer	Endogenous Metabolite Biochemical Assay Reagents
Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics .

HY-14617

Paradol 4 Publications Verification [6]-Gingerone; [6]-Paradol	Zingiber officinale Roscoe Monophenols Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	COX
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N1416

Pogostone 2 Publications Verification	Natural Products Entada phaseoloides (L.) Merr. Classification of Application Fields Labiatae Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Apoptosis Autophagy
Pogostone is isolated from patchouli oil with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy .

HY-N7132

(-)-Menthyl acetate L-Menthyl acetate	Structural Classification Natural Products Classification of Application Fields Acacia farnesiana (Linn.) Willd. Labiatae Other Diseases Plants Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Derivative
(-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Others
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-P0244

Dermorphin	Natural Products Animals Phenols Polyphenols Source Classification	Opioid Receptor
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-N1407

Polygalaxanthone III	Structural Classification Xanthones Classification of Application Fields Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd. Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 STAT
Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC₅₀ of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage .

HY-N7113

Squalane	Structural Classification Natural Products Animals Classification of Application Fields Marine natural products Disease Research Fields Source Classification Cancer	Environmental Pollutants
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-W015300

Suberic acid Octanedioic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite Akt TGF-β Receptor p38 MAPK
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-N0769

Isopimpinellin 1 Publications Verification	Infection Microorganisms Classification of Application Fields Coumarins Soroseris hookeriana (C. B. Clarke) Stebbins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis Parasite
Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .

HY-N7055

Trierucin Trierucoylglycerol	Structural Classification other families Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Lipid Source Classification	Drug Derivative
Trierucin (Trierucoylglycerol) is a triester formed by glycerol and erucic acid, which serves as an occlusive skin conditioning agent and non-aqueous thickener in cosmetics. Long-term feeding of Trierucin to rats induces chronic toxicities such as cardiac lipid deposition and fibrosis .

HY-141579

Sphingosine (d17:1)	Animals Source Classification	Others
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin .

HY-P0263

Dermaseptin	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Fungal Antibiotic
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-N7074

Lanolin	Structural Classification Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Bacterial
Lanolin is a yellow fat that can be extracted from wool. Lanolin can be used as a skin moisturizer and applied topically to relieve nipple pain and chapping during lactation .

HY-B1461

Deoxyarbutin	Natural Products Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification	Tyrosinase Apoptosis
Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-P0269

Magainin 1 Magainin I	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Fungal Antibiotic
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-N10496

Sericoside	Triterpenes Terminalia sericea Burch. ex DC. Terpenoids Combretaceae Plants Source Classification	Others
Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .

HY-Y1129

3-Hydroxypyridine	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Photosensitizer Apoptosis
3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .

HY-Y1809

1-Hydroxyoctadecane Stearyl alcohol	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Biochemical Assay Reagents
1-Hydroxyoctadecane (Stearyl alcohol) is a long-chain fatty alcohol and excipient. 1-Hydroxyoctadecane forms a closed oil film, thereby reducing transepidermal water loss (TEWL) and promoting skin moisturization. 1-Hydroxyoctadecane improves Imiquimod (HY-B0180)-induced psoriatic skin inflammation in mice .

HY-P0253

Xenopsin	Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Neurotensin Receptor
Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin . Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion .

HY-118157

3,5,7-Trimethoxyflavone	Flavonoids Flavones Orchidaceae Plants Nervilia concolor (Blume) Schltr. Source Classification	MMP
3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .

HY-N7677

Isookanin	Structural Classification Classification of Application Fields Plants Compositae Infection Flavonoids Deguelia rufescens (Benth.) R.A.Camargo & A.M.G.Azevedo Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	VZV HSV
Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity .

HY-N0543R

Allantoin (Standard) 5-Ureidohydantoin (Standard)	Structural Classification Natural Products Microorganisms Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Imidazoline Receptor Endogenous Metabolite
Allantoin (Standard) is the analytical standard of Allantoin. This product is intended for research and analytical applications. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-N0555

Escin IB	Triterpenes Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Metabolic Disease Plants Disease Research Fields Source Classification	Lipase
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-126931

Dinophysistoxin 1 DTX 1	Other Terpenoids Structural Classification Animals Terpenoids Source Classification	Endogenous Metabolite
Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well .

HY-W010098R

Terephthalic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Biochemical Assay Reagents
Terephthalic acid (Standard) is the analytical standard of Terephthalic acid. This product is intended for research and analytical applications. Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .

HY-W020044R

DL-alpha-Tocopherol (Standard) 5+ Cited Publications DL-α-Tocopherol (Standard)	Duchesnea indica (Andr.) Focke Classification of Application Fields Rosaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Reference Standards Ferroptosis DNA/RNA Synthesis Apoptosis
DL-alpha-Tocopherol (Standard) is the analytical standard of DL-alpha-Tocopherol. This product is intended for research and analytical applications. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-B1695R

Methyl nicotinate (Standard) Nicotinic acid methyl ester (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Others
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-119358R

Traumatic Acid (Standard)	Structural Classification Microorganisms Leguminosae Ketones, Aldehydes, Acids Plants Phaseolus vulgaris Linn. Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid (Standard) is the analytical standard of Traumatic Acid. This product is intended for research and analytical applications. Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].

HY-W013521

Hexyl salicylate	Structural Classification Monophenols Rubiaceae Phenols Uncaria macrophylla Wall. Plants Source Classification	Environmental Pollutants
Hexyl Salicylate is a commonly used fragrance component, widely applied in cosmetics, perfumes, cleaning products, etc. Hexyl Salicylate has low acute toxicity, no irritation to human skin, no phototoxicity and no photosensitization .

HY-150177

Mannose 6 phosphate	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Drug Intermediate
Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging .

HY-P0324

Parasin I	Infection Natural Products Classification of Application Fields Animals Disease Research Fields Source Classification	Bacterial
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-N15684

Rhodoxanthin	Natural Products Animals Source Classification	Others
Rhodoxanthin is a carotenoid. Rhodoxanthin exerts antioxidant activity via free radical scavenging and lipid peroxidation inhibition. Rhodoxanthin is promising for research of oxidative stress-related diseases (e.g., UV-induced skin damage) .

HY-N1151

Thunberginol C	Structural Classification Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial Cholinesterase (ChE) MMP TNF Receptor
Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC₅₀ values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety .

HY-N16417

Elsinochrome C	Quinones Structural Classification Microorganisms Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .

HY-P0244A

Dermorphin TFA	Animals Phenols Polyphenols Source Classification	Opioid Receptor
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-113008R

Urocanic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Urocanic acid (Standard) is the analytical standard of Urocanic acid. This product is intended for research and analytical applications. Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).

HY-N16397

Anhydrofulvic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Anhydrofulvic acid is a polyketide with antibacterial activity (notably against MRSA, MIC=8 mg/mL). Anhydrofulvic acid is promising for research of Gram-positive infections (e.g., skin, bloodstream) .

HY-123025

Schizozygine	Apocynaceae Structural Classification Alkaloids Schizozygia coffeoides Baill. Other Alkaloids Plants Source Classification	Fungal
Schizozygine is an alkaloid that can be isolated from Schizozygia caffaeoides. Schizozygia caffaeoides has been used as a traditional medicine for skin disease. The leaf extracts has high antifungal and antimicrobial activity .

HY-N0776R

Isorhamnetin (Standard) 3'-Methylquercetin (Standard)	Cardiovascular Disease Classification of Application Fields Hippophaë rhamnoides Plants Endogenous metabolite Flavonoids Leguminosae Elaeagnaceae Phenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards MEK PI3K Endogenous Metabolite
Isorhamnetin (Standard) is the analytical standard of Isorhamnetin. This product is intended for research and analytical applications. Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

HY-N1416R

Pogostone (Standard)	Structural Classification Natural Products Entada phaseoloides (L.) Merr. Labiatae Plants Source Classification	Reference Standards Bacterial Apoptosis Autophagy
Pogostone (Standard) is the analytical standard of Pogostone. This product is intended for research and analytical applications. Pogostone is isolated from patchouli oil?with anti-bacterial and anti-cancer activities.?Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 μg/ml .?Pogostone induces cell apoptosis and autophagy .

Cat. No.	Product Name	Chemical Structure

HY-N0543S

Allantoin-13C2,15N4
Allantoin- ¹³C₂, ¹⁵N₄ is the ¹³C and ¹⁵N labeled Allantoin . Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth .

HY-76025S

1,4-Dibromobenzene-d4
1,4-Dibromobenzene-d₄ is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans .

HY-W015967S

Glycolic acid-d2
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-W010098S1

Terephthalic acid-13C2 1 Publications Verification
Terephthalic acid- ¹³C₂ is the ¹³C-labeled Terephthalic acid. Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .

HY-N7113S

Squalane-d62
Squalane-d₆₂ is the deuterium labeled Squalane . Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-B0704S

Azelaic acid-d14
Azelaic acid-d₁₄ is the deuterium labeled Azelaic acid . Azelaic acid is an organic compound produced by the ozonolysis of oleic acid;component of a number of hair and skin conditioners .

HY-W010098S

Terephthalic acid-d4
Terephthalic acid-d₄ is the deuterium labeled Terephthalic acid. Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .

HY-B0935S

Benzyl benzoate-d5
Benzyl benzoate-d₅ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-B0935S1

Benzyl benzoate-d12 1 Publications Verification
Benzyl benzoate-d₁₂ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-111355S

Cholesterol sulfate-d7 sodium

Cholesterol sulfate sodium-d₇ is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.

HY-30151S

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

HY-113008S1

Urocanic acid-13C3
Urocanic acid- ¹³C₃ is the ¹³C labeled Urocanic acid . Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR) .

HY-N2086S

Ethyl palmitate-d31
Ethyl palmitate-d₃₁ is the deuterium labeled Ethyl palmitate. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent .

HY-B0688S

Dapsone-d8
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-W585956

Triclocarban-13C6

Triclocarban- ¹³C₆ is the ¹³C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-B0928S

Homosalate-d4
Homosalate-d₄ is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.

HY-30270S

Mequinol-d4
Mequinol-d₄ is the deuterium labeled Mequinol[1]. Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis. Mequinol is used for skin depigmentation[2].

HY-W778203

Glycolic acid-13C2
Glycolic acid- ¹³C₂ is the ¹³C-labeled Glycolic acid (HY-W015967). Glycolic acid- ¹³C₂ is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-14283S1

Luliconazole-d3
Luliconazole-d₃ (NND 502-d₃) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-W009326S

Laurocapram-15N
Laurocapram-15N is a deuterated labeled Laurocapram . Laurocapram is a chemical penetration enhancer that increases the permeability of compounds through the skin and mucous membranes, thereby improving their local or systemic efficacy. Laurocapram improves the skin permeability of a variety of hydrophilic and lipophilic compounds .

HY-Y1129S

3-Hydroxypyridine-d4
3-Hydroxypyridine-d₄ is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .

HY-130187S

Sapienic acid-d19

Sapienic acid-d19 is a deuterated labeled Sapienic acid . Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

HY-B0220S3

Erythromycin-13C2
Erythromycin-13C2 is a macrolide antibiotic that can be used to treat respiratory infections, skin infections, and chlamydia infections .

HY-W740028

Cefditoren-d3 sodium

Cefditoren-d₃ (sodium) (ME 1206-d₃) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-17452AS

Cefditoren pivoxil-d3

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-14957AS

Ozenoxacin-d3 hydrochloride
Ozenoxacin-d₃ (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections .

HY-14957S

Ozenoxacin-d3
Ozenoxacin-d₃ is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d₃ is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-13600S1

Clobetasol propionate-d5
Clobetasol propionate-d₅ is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC₅₀ of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .

HY-W020044S1

DL-alpha-Tocopherol-d9
DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol . DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-109044S

Tapinarof-d5
Tapinarof-d₅ (WBI-1001-d₅) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice .

HY-W724343

Lauryl benzalkonium-d5 chloride
Lauryl benzalkonium-d₅ chloride (Dimethylbenzyllaurylammonium-d₅ chloride) is the deuterium labeled Lauryl benzalkonium chloride (HY-B1549). Lauryl benzalkonium (Dimethylbenzyllaurylammonium) chloride is a cationic surfactant that may produce some irritant contact dermatitis (ICD) to the skin .

HY-125407S

Palmitoyl serinol-d5
Palmitoyl serinol-d₅ is the deuterium labeled Palmitoyl serinol . Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin .

HY-W020044S

DL-alpha-Tocopherol-13C3
DL-alpha-Tocopherol- ¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-B0316S1

Avobenzone-d3
Avobenzone-d₃ is deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist .

HY-B0316S

Avobenzone-13C,d3
Avobenzone- ¹³C,d₃ is the ¹³C- and deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist .

HY-B0458AS

Cefprozil-d4
Cefprozil-d₄ is the deuterium labeled Cefprozi (HY-B0458A) . Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .

HY-14283S

Luliconazole-13C7
Luliconazole- ¹³C₇ (NND 502- ¹³C₇) is ¹³C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .

HY-108411S

Emedastine-13C,d3 fumarate
Emedastine- ¹³C,d₃ fumarate is the ¹³C- and deuterium labeled Emedastine. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-B1805S

Triclocarban-d4

Triclocarban-d₄ is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-W014612S

Eugenol acetate-d3
Eugenol acetate-d₃ is the deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-14744S

Levamlodipine-d4

Levamlodipine-d₄ is the deuterium labeled Levamlodipine. Levamlodipine ((S)-Amlodipine; Levoamlodipin) is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine can be used in research related to hypertension and atherosclerosis .

HY-W707384

Candesartan Cilexetil-d11
Candesartan Cilexetil-d₁₁ (TCV-116-d₁₁) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure .

HY-B0226S

Nitrofurazone-13C,15N2

Nitrofurazone- ¹³C, ¹⁵N₂ (Nitrofural- ¹³C, ¹⁵N₂) is the ¹³C and ¹⁵N labled Nitrofurazone (HY-B0226) . Nitrofurazone is a potential antibiotic that can be used topically to treat wounds, burns, ulcers and skin infections to combat various microorganisms and to prepare surfactants . Nitrofurazone may affect the ecosystem function in Marine environment and affect the functional processes of epiphytic fauna .

HY-W011303S

Phytosphingosine-d7

Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-A0294S

Ertapenem-d4
Ertapenem-d₄ (MK-0826-d₄) is deuterium labeled Ertapenem. Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .

HY-B0136S

Cefdinir-13C,15N2

Cefdinir- ¹³C, ¹⁵N₂ (FK-482- ¹³C, ¹⁵N₂) is ¹³C and ¹⁵N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18985G

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter .

HY-U00449G

AGN 193109	RAR/RXR	Cancer
AGN 193109 (GMP) is AGN 193109 (HY-U00449) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AGN 193109 is a specific and highly effective retinoic acid receptor (RAR) antagonist . AGN 193109 (GMP) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

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