1. Neuronal Signaling
  2. Tau Protein
  3. Semorinemab

Semorinemab  (Synonyms: RG 6100; RO7105705; MTAU-9937A)

Cat. No.: HY-P99399 Purity: 99.90%
COA

Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.

For research use only. We do not sell to patients.

Semorinemab Chemical Structure

Semorinemab Chemical Structure

CAS No. : 2159141-27-0

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Based on 1 publication(s) in Google Scholar

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Description

Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].

In Vitro

Semorinemab binds to human Tau and recombinant cynomolgus monkey Tau with Kd values of 3.8 and 11.2 nM, respectively[1].
Semorinemab prevents neurons to uptake oligomeric Tau[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Semorinemab (3, 10 and 30 mg/kg; i.p., once weekly for 13 weeks) reduces accumulation of Tau pathology in a transgenic (Tg) mouse model of tauopathy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result: Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Semorinemab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 99.90%

References
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Semorinemab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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