2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK FLT3
  4. SG3-179

SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S).

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SG3-179

SG3-179 Chemische Struktur

CAS. Nr. : 1877286-78-6

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SG3-179 Related Antibodies

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Beschreibung

SG3-179 is a potent inhibitor against the BET bromodomain proteins. SG3-179 is also a JAK2 and FLT3 inhibitor. SG3-179 causes a rapid reduction in HOXB13 protein expression. SG3-179 is promising for research of multiple myeloma (MM1.S)[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK-293T IC50
140 nM
Compound: SG3-179
Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay
Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay
[PMID: 34710325]
MM1.S IC50
26 nM
Compound: SG3-179
Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay
Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay
[PMID: 34710325]
MM1.S IC50
61 nM
Compound: SG3-179
Growth inhibition of human MM1.S cells incubated for 72 hrs by CellTiter-Blue assay
Growth inhibition of human MM1.S cells incubated for 72 hrs by CellTiter-Blue assay
[PMID: 35867655]
Molekulargewicht

604.14

Formel

C28H35ClFN7O3S
CAS. Nr.
SMILES

O=C(NC1CCN(C)CC1)C2=CC=C(NC3=NC=C(C)C(NC4=CC=C(Cl)C(NS(=O)(C(C)(C)C)=O)=C4)=N3)C=C2F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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SG3-179 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SG3-1791877286-78-6JAKFLT3Janus kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3BETJAK2HOXB13MM1.SInhibitorinhibitorinhibit

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