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Cat. No.: HY-162252

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SIRT2-IN-12

SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC₅₀ value of 50 μM.

For research use only. We do not sell to patients.

CAS No.: 3049202-51-6
Formula: C₂₃H₂₁Cl₂NO₃
Molecular Weight:430.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SIRT2-IN-12 Chemical Structure

CAS No.: 3049202-51-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC₅₀ value of 50 μM^[1].

All Sirtuin Isoforms :

Chemical Information

CAS No. 3049202-51-6
Molecular Weight 430.32
Formula C₂₃H₂₁Cl₂NO₃
SMILES

O=C1C2=C(OC3=C1C=CC=C3Cl)C=CC(CNCCC4=CC=CC=C4OC)=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mazur G, et al. Novel xanthone derivatives as potent sirtuin 2 inhibitors. Bioorg Med Chem Lett. 2024 Mar 1;100:129620. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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