SJ995973

Name: SJ995973
Brand: MedChemExpress
SKU: HY-145125
Rating: 5.0 (0 reviews)

Cat. No.: HY-145125 Pureza: 98.88%: Ficha de datos
COA

SDS
Instrucciones de manejo
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SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins.

Para uso exclusivo en investigación. No vendemos a pacientes.

SJ995973 Estructura química

No. CAS : 2882065-25-8

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Based on 1 Customer Validation

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Ver todos los productos específicos de isoformas PROTACs:

Ver todas las isoformas

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Actividad biológica
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Referencias
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Descripciòn

SJ995973 (PROTAC) is a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins.

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	1.83 nM Compound: SJ995973; 26	Cytotoxicity against human MV4-11 cells Cytotoxicity against human MV4-11 cells	[PMID: 36202064]
MV4-11	IC₅₀	3 pM Compound: 4c/SJ995973	Antiproliferative activity against human MV4-11 after 3 days by CellTiter-Glo assay Antiproliferative activity against human MV4-11 after 3 days by CellTiter-Glo assay	[PMID: 36274273]
MV4-11	IC₅₀	3 pM Compound: SJ995973	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by CellTiter-Glo assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by CellTiter-Glo assay	[PMID: 37178483]
MV4-11	IC₅₀	3 pM Compound: SJ995973; 26	Cytotoxicity against human MV4-11 cells measured after 96 hrs Cytotoxicity against human MV4-11 cells measured after 96 hrs	[PMID: 36202064]

Peso molecular

730.28

Fòrmula

C₃₇H₄₀ClN₇O₅S

No. CAS

2882065-25-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (136.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3693 mL	6.8467 mL	13.6934 mL
5 mM	0.2739 mL	1.3693 mL	2.7387 mL
10 mM	0.1369 mL	0.6847 mL	1.3693 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 98.88%

Select Batch:

Ficha de datos (269 KB) SDS (252 KB)

COA (245 KB) HNMR (239 KB) LCMS (105 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3693 mL	6.8467 mL	13.6934 mL	34.2334 mL
	5 mM	0.2739 mL	1.3693 mL	2.7387 mL	6.8467 mL
	10 mM	0.1369 mL	0.6847 mL	1.3693 mL	3.4233 mL
	15 mM	0.0913 mL	0.4564 mL	0.9129 mL	2.2822 mL
	20 mM	0.0685 mL	0.3423 mL	0.6847 mL	1.7117 mL
	25 mM	0.0548 mL	0.2739 mL	0.5477 mL	1.3693 mL
	30 mM	0.0456 mL	0.2282 mL	0.4564 mL	1.1411 mL
	40 mM	0.0342 mL	0.1712 mL	0.3423 mL	0.8558 mL
	50 mM	0.0274 mL	0.1369 mL	0.2739 mL	0.6847 mL
	60 mM	0.0228 mL	0.1141 mL	0.2282 mL	0.5706 mL
	80 mM	0.0171 mL	0.0856 mL	0.1712 mL	0.4279 mL
	100 mM	0.0137 mL	0.0685 mL	0.1369 mL	0.3423 mL

SJ995973 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ9959732882065-25-8SJ 995973SJ-995973PROTACsInhibitorinhibitorinhibit

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SJ995973

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SJ995973 Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTACs:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

SJ995973 Related Classifications

Keywords:

Productos vistos recientemente:

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SAFETY DATA SHEET (SDS)

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