Sulfanilamide-d₄ (Synonyms: Sulphanilamide-d₄)

Name: Sulfanilamide-d 4
Brand: MedChemExpress
SKU: HY-B0242S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0242S1 Pureza: 99.99%: Ficha de datos
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Sulfanilamide-d₄ is the deuterium labeled Sulfanilamide. Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

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Sulfanilamide-d₄ Estructura química

No. CAS : 77435-46-2

Tamaño	Stock	Cantidad
1 mg	Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Sulfanilamide-d₄:

Sulfanilamide In-stock

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Descripciòn

Sulfanilamide-d₄ is the deuterium labeled Sulfanilamide. Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

176.23

Fòrmula

C₆H₄D₄N₂O₂S

No. CAS

77435-46-2

Unlabeled CAS

63-74-1

Appearance

Solid

Color

White to off-white

SMILES

NS(=O)(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (567.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10 mg/mL (56.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6744 mL	28.3720 mL	56.7440 mL
5 mM	1.1349 mL	5.6744 mL	11.3488 mL
10 mM	0.5674 mL	2.8372 mL	5.6744 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.99%

Select Batch:

Ficha de datos (275 KB) SDS (252 KB)

COA (252 KB) HNMR (263 KB) RP-HPLC (1135 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. McCullough, J.L. and T.H. Maren, Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother, 1973. 3(6): p. 665-9. [Content Brief]

[3]. Meneau, I., et al., Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother, 2004. 48(7): p. 2610-6. [Content Brief]

[4]. Hughes, W.T. and J. Killmar, Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother, 1996. 40(4): p. 962-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.6744 mL	28.3720 mL	56.7440 mL	141.8601 mL
	5 mM	1.1349 mL	5.6744 mL	11.3488 mL	28.3720 mL
	10 mM	0.5674 mL	2.8372 mL	5.6744 mL	14.1860 mL
	15 mM	0.3783 mL	1.8915 mL	3.7829 mL	9.4573 mL
	20 mM	0.2837 mL	1.4186 mL	2.8372 mL	7.0930 mL
	25 mM	0.2270 mL	1.1349 mL	2.2698 mL	5.6744 mL
	30 mM	0.1891 mL	0.9457 mL	1.8915 mL	4.7287 mL
	40 mM	0.1419 mL	0.7093 mL	1.4186 mL	3.5465 mL
	50 mM	0.1135 mL	0.5674 mL	1.1349 mL	2.8372 mL
DMSO	60 mM	0.0946 mL	0.4729 mL	0.9457 mL	2.3643 mL
	80 mM	0.0709 mL	0.3547 mL	0.7093 mL	1.7733 mL
	100 mM	0.0567 mL	0.2837 mL	0.5674 mL	1.4186 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sulfanilamide-d₄ Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfanilamide-d₄77435-46-2Sulphanilamide-d₄BacterialAntibioticInhibitorinhibitorinhibit

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Sulfanilamide-d4 (Synonyms: Sulphanilamide-d4)

Revisión del cliente

Other Forms of Sulfanilamide-d4:

Sulfanilamide-d4 Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Antibiotic:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Sulfanilamide-d4 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Sulfanilamide-d4 Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report

Sulfanilamide-d₄ (Synonyms: Sulphanilamide-d₄)

Other Forms of Sulfanilamide-d₄:

Sulfanilamide-d₄ Related Antibodies

Sulfanilamide-d₄ Related Antibodies

Sulfanilamide-d₄ Related Classifications