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Cat. No.: HY-175017

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Survivin-IN-2

Survivin-IN-2 is a survivin inhibitor. Survivin-IN-2 shows cytotoxicity in cells with IC₅₀s of 0.53 μM (C4-2 cells) and 1.06 μM (PC-3 cells). Survivin-IN-2 effectively suppresses xenograft tumor growth without apparent toxicity and eliminates survivin in the tumors. Survivin-IN-2 can be used for the study of prostate cancer.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₄F₆N₄
Molecular Weight:448.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Survivin-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Survivin-IN-2 (Compound 7I14) (1 μM, 48 h) reduces survivin expression in C4-2 and PC-3 cells^[1].
Survivin-IN-2 (450-600 nM, 48 h) exhibits reduced cytotoxic activity in survivin-overexpressing C4-2 cells and a Docetaxel (HY-B0011) resistant DU145 cell line (DU145Doc)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Survivin-IN-2 (Compound 7I14) (15 mg/kg, i.p., twice a week for four weeks) suppresses tumor growth in PC-3 cell xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NSG mice implanted with PC-3 xenograft tumors^[1]
Dosage:

15 mg/kg
Administration:

i.p. twice a week for four weeks
Result:

Suppressed the growth of the PC-3 xenograft tumors.
Upregulated the level of cleaved caspase-3.
Reduced the survivin level.
Did not significantly affect the body weight of the treated mice compared with the control mice.

Chemical Information

Molecular Weight 448.36
Formula C₂₂H₁₄F₆N₄
SMILES

FC(F)(F)C(C=C1)=CC=C1NC2=NC3=CC=CC=C3N=C2NC4=CC=C(C(F)(F)F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cui Q, et al. Design, synthesis, and evaluation of quinoxaline-based survivin inhibitors for castration-resistant prostate cancer. Bioorg Chem. 2025 Jul 1;163:108714

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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