1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. SY-640

SY-640 

Cat. No.: HY-106947 Purity: 98.17%
Handling Instructions

SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice.

For research use only. We do not sell to patients.

SY-640 Chemical Structure

SY-640 Chemical Structure

CAS No. : 168705-70-2

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5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

SY-640 inhibits the number of liver-infiltrating cells and attenuates the increased expression of leukocyte function-associated antigen-1 on these cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect[1].
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

207.23

Formula

C₁₁H₁₃NO₃

CAS No.

168705-70-2

SMILES

CC(N(C)CC1=CC2=C(OCO2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (482.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8256 mL 24.1278 mL 48.2556 mL
5 mM 0.9651 mL 4.8256 mL 9.6511 mL
10 mM 0.4826 mL 2.4128 mL 4.8256 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SY-640SY640SY 640Endogenous MetaboliteAcetamidehepatoprotectivePropionibacteriumacnesLipopolysaccharideInhibitorinhibitorinhibit

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Product Name:
SY-640
Cat. No.:
HY-106947
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