1. Cell Cycle/DNA Damage
  2. Antifolate
  3. Tetroxoprim

Tetroxoprim (Synonyms: HE 781)

Cat. No.: HY-107033
Handling Instructions

Tetroxoprim is an antimicrobial DHFR inhibitor.

For research use only. We do not sell to patients.

Tetroxoprim Chemical Structure

Tetroxoprim Chemical Structure

CAS No. : 53808-87-0

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Description

Tetroxoprim is an antimicrobial DHFR inhibitor[1].

In Vitro

Tetroxoprim brings about a 50% in vitro inhibition with E. coli, at a concentration of 4 x 10-9M[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.37

Formula

C₁₆H₂₂N₄O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (49.85 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9907 mL 14.9535 mL 29.9070 mL
5 mM 0.5981 mL 2.9907 mL 5.9814 mL
10 mM 0.2991 mL 1.4953 mL 2.9907 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (4.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Tetroxoprim
Cat. No.:
HY-107033
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