TGFβ1-IN-3
TGFβ1-IN-3 is a diarylacylhydrazones derivative that effectively suppresses the activation and proliferation of fibroblasts. TGFβ1-IN-3 can be used for idiopathic pulmonary fibrosis (IPF) research.
For research use only. We do not sell to patients.
- CAS No.: 2883813-58-7
- Formula: C23H30N4O5
- Molecular Weight:442.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
0.57 μM
Compound: 44
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Antiproliferative activity against NIH3T3 cells after 72 hrs by MTT assay
Antiproliferative activity against NIH3T3 cells after 72 hrs by MTT assay
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[PMID: 36401884] |
TGFβ1-IN-3 (compound 44) shows inhibitory effect against NIH-3T3 cells with an IC50 of 0.57 μM[1].
TGFβ1-IN-3 (compound 44; 10 μM; for 24 h) inhibits TGF-β1-induced abnormal activation of NIH-3T3 and A549 cells, as well as migration and epithelial-mesenchymal transition (EMT) of A549 cells[1].
TGFβ1-IN-3 (compound 44) could bind to STAT3, and able to interact with Ile659, and the hydrophilic group piperidine formed intermolecular forces with Ser636, Arg609, and Pro639. The nitrofuran of TGFβ1-IN-3 could interact with Lys658[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH-3T3 or A549 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Were able to inhibit TGF-β1-induced activation of fibroblasts in vitro.
Pharmacokinetic parameters of TGFβ1-IN-3 (compound 44) in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (6-10 weeks) injected with Bleomycin for establishing pulmonary fibrosis model[1].
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Dosage:30 mg/kg, 60 mg/kg
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Administration:Orally administration; once daily; for 22 days
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Result:Could reverse the pulmonary fibrosis in treatment model.
Chemical Information
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CAS No. 2883813-58-7
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Molecular Weight 442.51
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Formula C23H30N4O5
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SMILES
O=C(C1=CC=C(C=C1)OCCCCCCN2CCCCC2)N/N=C/C3=CC=C(O3)[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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