TLR8 agonist 4
TLR8 agonist 4 showed effective inhibition on wild-type and drug-resistant (lamivudine and entecavir) HBV strains. The IC50 values are 0.15 and 0.10 respectively μM.
For research use only. We do not sell to patients.
- CAS No.: 2761697-69-0
- Formula: C28H27N5O5S
- Molecular Weight:545.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HBV 0.10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | CC50 |
>10 μM
Compound: 5l
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Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay
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[PMID: 35123297] |
| HepG2 2.2.15 | IC50 |
0.15 μM
Compound: 5l
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Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication
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[PMID: 35123297] |
Chemical Information
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CAS No. 2761697-69-0
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Molecular Weight 545.61
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Formula C28H27N5O5S
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SMILES
COC1=C(C=CC=C1)CSC2=NC3=CC=C(C=C3C(N2CC4=CC=CO4)=O)OCCCOC5=NC(N)=NC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR8 agonist 4 Related Classifications
HY-144215 Related Classifications
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