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Cat. No.: HY-144215

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TLR8 agonist 4

TLR8 agonist 4 showed effective inhibition on wild-type and drug-resistant (lamivudine and entecavir) HBV strains. The IC₅₀ values are 0.15 and 0.10 respectively μM.

For research use only. We do not sell to patients.

CAS No.: 2761697-69-0
Formula: C₂₈H₂₇N₅O₅S
Molecular Weight:545.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TLR8 agonist 4 Chemical Structure

CAS No.: 2761697-69-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TLR8 agonist 4 showed effective inhibition on wild-type and drug-resistant (lamivudine and entecavir) HBV strains. The IC₅₀ values are 0.15 and 0.10 respectively μM.

IC₅₀ & Target

HBV

0.10 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2 2.2.15	CC₅₀	>10 μM Compound: 5l	Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay Cytotoxicity against human HepG2 2.2.15 cells infected with Hepatitis B virus assessed as reduction in cell growth by CCK8 assay	[PMID: 35123297]
HepG2 2.2.15	IC₅₀	0.15 μM Compound: 5l	Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication Antiviral activity against Hepatitis B virus infected in human HepG2 2.2.15 cells assessed as inhibition of DNA replication	[PMID: 35123297]

Chemical Information

CAS No. 2761697-69-0
Molecular Weight 545.61
Formula C₂₈H₂₇N₅O₅S
SMILES

COC1=C(C=CC=C1)CSC2=NC3=CC=C(C=C3C(N2CC4=CC=CO4)=O)OCCCOC5=NC(N)=NC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qiu J, et al. Design and synthesis of novel quinazolinone derivatives as anti-HBV agents with TLR8 agonist effect. Eur J Med Chem. 2022 Mar 5;231:114159. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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