2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Reactive Oxygen Species (ROS) Environmental Pollutants Herbicide
  4. Trifludimoxazin

Trifludimoxazin is a click chemistry reagent, a protoporphyrinogen oxidase (PPO) inhibitor and herbicide. Trifludimoxazin inhibits PPO, accumulates reactive oxygen species, damages cell membranes, and thereby causes weed death. Trifludimoxazin exhibits high-efficiency activity in controlling broadleaf weeds and grassy weeds.

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Trifludimoxazin

Trifludimoxazin Chemical Structure

CAS No. : 1258836-72-4

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Based on 1 publication(s) in Google Scholar

Trifludimoxazin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Trifludimoxazin is a click chemistry reagent, a protoporphyrinogen oxidase (PPO) inhibitor and herbicide. Trifludimoxazin inhibits PPO, accumulates reactive oxygen species, damages cell membranes, and thereby causes weed death. Trifludimoxazin exhibits high-efficiency activity in controlling broadleaf weeds and grassy weeds[1][2].

In Vitro

Trifludimoxazin potently inhibits wild-type and multiple mutant variants of purified A. tuberculatus PPO2 in vitro, with IC50 values as low as 2.45 × 10-10 M for wild-type enzyme, and retains inhibitory activity against most R128(X) ΔG210 double-mutant enzymes[1].
Trifludimoxazin (3.35-12.5 g a.i. ha-1; 7 days post-treatment) reduces growth of transgenic A. thaliana lines ectopically expressing R128(X) ΔG210 double-mutant A. tuberculatus PPO2 at field-relevant doses, with greater efficacy than saflufenacil for most tested mutant variants[1].
Trifludimoxazin maintains binding affinity to ΔG210, R128G, and G399A mutant A. tuberculatus PPO2 proteins via unique interactions with the enzyme's beta-sheet backbone, which are less affected by common target site mutations than interactions of other PPO inhibitors[1].
Trifludimoxazin (2-16 g ai ha-1; 7-20 d postapplication) effectively controls a range of annual broadleaf and grass weed species (including resistant Lolium perenne ssp. multiflorum) in greenhouse postemergence trials when assessed 7 and 20 d postapplication[2].
Trifludimoxazin (2.7 g ai ha-1; 24-72 h after application) shows moderate foliar uptake (20-29% for barnyardgrass, 41-90% for Italian ryegrass) with excellent metabolic stability in barnyardgrass and lower stability in Italian ryegrass, and does not translocate to roots in either grass species when assessed 24 and 72 h postapplication[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trifludimoxazin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: E. coli hemG mutants complemented with wild-type or mutant A. tuberculatus PPO2 proteins
Concentration: 10-5 M (serial 1:5 dilutions in 60% dimethyl sulfoxide)
Incubation Time: 24 h
Result: Inhibited growth of E.
coli hemG mutants expressing wild-type A.
tuberculatus PPO2 with an IC50 of 9.27 × 10-10 M.
Inhibited growth of mutants expressing ΔG210 single-mutant PPO2 with an IC50 of 1.18 × 10-9 M.
Inhibited growth of mutants expressing various R128(X) ΔG210 double-mutant PPO2 enzymes with IC50 values ranging from 9.86 × 10-9 M to 9.00 × 10-8 M.
Molecular Weight

412.34

Formula

C16H11F3N4O4S
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(N(C1=C(F)C=C(OC(F)(F)C(N2CC#C)=O)C2=C1)C(N3C)=O)N(C)C3=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (242.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4252 mL 12.1259 mL 24.2518 mL
5 mM 0.4850 mL 2.4252 mL 4.8504 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4252 mL 12.1259 mL 24.2518 mL 60.6296 mL
5 mM 0.4850 mL 2.4252 mL 4.8504 mL 12.1259 mL
10 mM 0.2425 mL 1.2126 mL 2.4252 mL 6.0630 mL
15 mM 0.1617 mL 0.8084 mL 1.6168 mL 4.0420 mL
20 mM 0.1213 mL 0.6063 mL 1.2126 mL 3.0315 mL
25 mM 0.0970 mL 0.4850 mL 0.9701 mL 2.4252 mL
30 mM 0.0808 mL 0.4042 mL 0.8084 mL 2.0210 mL
40 mM 0.0606 mL 0.3031 mL 0.6063 mL 1.5157 mL
50 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2126 mL
60 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0105 mL
80 mM 0.0303 mL 0.1516 mL 0.3031 mL 0.7579 mL
100 mM 0.0243 mL 0.1213 mL 0.2425 mL 0.6063 mL
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Trifludimoxazin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifludimoxazin1258836-72-4Reactive Oxygen Species (ROS)Environmental PollutantsHerbicideEnvironmental Contaminantstarget site resistancePPO1barnyardgrassPPO2Italian ryegrassE. coli hemG mutantsArabidopsisLolium perenne ssp. multiflorumbeta-sheet backboneAmaranthus tuberculatusInhibitorinhibitorinhibit

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