Trk-IN-2

Cat. No.: HY-12328: Data Sheet Handling Instructions
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Trk-IN-2 is an orally active pan-Trk kinase inhibitor with an TrkA IC₅₀ of 9 nM. Trk-IN-2 exhibits pharmacodynamic effects in rat models of inflammatory pain and neuropathic pain.Trk-IN-2 can be used for the research of inflammatory pain, neuropathic pain.

For research use only. We do not sell to patients.

Trk-IN-2 Chemical Structure

CAS No. : 1614229-04-7

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•Related Small Molecules:

•Related Proteins:

View All Trk Receptor Isoform Specific Products:

View All Isoforms

TrkA TrkB TrkC Trk

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	7 nM Compound: 11	Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay	[PMID: 24914455]

In Vitro

Trk-IN-2 (compound 11) inhibits TrkA with an IC₅₀ of 7 nM in cell-based assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.53

Formula

C₂₄H₂₄N₁₀O

CAS No.

1614229-04-7

SMILES

O=C(NC1=CC(=NN1C=2C=NC=CC2)C(C)(C)C)CN3N=NC(=C3)C=4C=NC(=CC4)N5C=NC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Norman BH, et al. Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017;60(1):66-88. [Content Brief]

Trk-IN-2 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trk-IN-21614229-04-7Trk ReceptorTropomyosin related kinase receptorTrkA enzymeinflammatory painpan-Trk kinaseneuropathic painrat modelsInhibitorinhibitorinhibit

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