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Cat. No.: HY-12328

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Trk-IN-2

Trk-IN-2 is an orally active pan-Trk kinase inhibitor with an TrkA IC₅₀ of 9 nM. Trk-IN-2 exhibits pharmacodynamic effects in rat models of inflammatory pain and neuropathic pain.Trk-IN-2 can be used for the research of inflammatory pain, neuropathic pain.

For research use only. We do not sell to patients.

CAS No.: 1614229-04-7
Formula: C₂₄H₂₄N₁₀O
Molecular Weight:468.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Trk-IN-2 Chemical Structure

CAS No.: 1614229-04-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	7 nM Compound: 11	Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay	[PMID: 24914455]

In Vitro

Trk-IN-2 (compound 11) inhibits TrkA with an IC₅₀ of 7 nM in cell-based assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1614229-04-7
Molecular Weight 468.53
Formula C₂₄H₂₄N₁₀O
SMILES

O=C(NC1=CC(=NN1C=2C=NC=CC2)C(C)(C)C)CN3N=NC(=C3)C=4C=NC(=CC4)N5C=NC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Norman BH, et al. Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017;60(1):66-88. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Trk-IN-2

All Trk Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Trk-IN-2 Related Classifications

HY-12328 Related Classifications