2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. TRV-7019

TRV-7019 is a BBB-penetrable radioligand for brain imaging that target butyrylcholinesterase. TRV-7019 can be used for the diagnosis of an amyloid disease, multiple sclerosis, a brain tumor, or butyrylcholinesterase activity.

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TRV-7019 Chemical Structure

TRV-7019 Chemical Structure

CAS No. : 2598164-15-7

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Based on 1 publication(s) in Google Scholar

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Description

TRV-7019 is a BBB-penetrable radioligand for brain imaging that target butyrylcholinesterase. TRV-7019 can be used for the diagnosis of an amyloid disease, multiple sclerosis, a brain tumor, or butyrylcholinesterase activity[1].

IC50 & Target[1]

BChE

 

Molecular Weight

369.15

Formula

C14H12INO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC(OC)=CC=C1)OCC2=CC=C(I)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7089 mL 13.5446 mL 27.0893 mL
5 mM 0.5418 mL 2.7089 mL 5.4179 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7089 mL 13.5446 mL 27.0893 mL 67.7231 mL
5 mM 0.5418 mL 2.7089 mL 5.4179 mL 13.5446 mL
10 mM 0.2709 mL 1.3545 mL 2.7089 mL 6.7723 mL
15 mM 0.1806 mL 0.9030 mL 1.8060 mL 4.5149 mL
20 mM 0.1354 mL 0.6772 mL 1.3545 mL 3.3862 mL
25 mM 0.1084 mL 0.5418 mL 1.0836 mL 2.7089 mL
30 mM 0.0903 mL 0.4515 mL 0.9030 mL 2.2574 mL
40 mM 0.0677 mL 0.3386 mL 0.6772 mL 1.6931 mL
50 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3545 mL
60 mM 0.0451 mL 0.2257 mL 0.4515 mL 1.1287 mL
80 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8465 mL
100 mM 0.0271 mL 0.1354 mL 0.2709 mL 0.6772 mL
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TRV-7019 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRV-70192598164-15-7TRV7019TRV 7019Cholinesterase (ChE)ADamyloid multiple sclerosisbrain tumorInhibitorinhibitorinhibit

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