1. GPCR/G Protein
  2. Glucagon Receptor
  3. TT-OAD2

TT-OAD2 

Cat. No.: HY-129658A
Handling Instructions

TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment.

For research use only. We do not sell to patients.

TT-OAD2 Chemical Structure

TT-OAD2 Chemical Structure

CAS No. : 2382719-60-8

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Description

TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment[1][2].

IC50 & Target

EC50: 5 nM (GLP-1 receptor)[2]

In Vitro

TT-OAD2 (0-10 μM) inhibits GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner in HEK293A cells[1].

In Vivo

TT-OAD2 (3 mg/kg; intravenous injection; male human GLP-1 receptor knock-in and knockout mice) treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1].

Animal Model: Male human GLP-1 receptor knock-in and knockout mice (6-11 months of age) with intravenous glucose tolerance tests[1]
Dosage: 3 mg/kg
Administration: Intravenous injection (Single dose)
Result: Induced plasma insulin.
Molecular Weight

929.75

Formula

C₅₀H₄₉Cl₄N₃O₆

CAS No.

2382719-60-8

SMILES

O=C(O)[[email protected]](CC1=CC=C(C2=C(C)C(C)=NC=C2)C=C1)NC([[email protected]]3N([[email protected]](C4=CC=CC=C4)CC)CC5=C(C=C(OC[[email protected]](C6=CC=C(OCC7=CC=C(Cl)C(Cl)=C7)C=C6)O8)C8=C5)C3)=O.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TT-OAD2Glucagon ReceptorGCGRGLP-1diabetesobesityG-protein-couplednon-peptideinsulinotropiccAMPcalciumpERK1/2β-arrestinInhibitorinhibitorinhibit

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TT-OAD2
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