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Cat. No.: HY-157310

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TTBK1-IN-3

TTBK1-IN-3 (Compound 18) is a potent inhibitor of TTBK1, with a biochemical IC₅₀ of 18 nM and a cellular IC₅₀ of 259 nM. TTBK1-IN-3 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 2735015-52-6
Formula: C₁₆H₁₆N₆O
Molecular Weight:308.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TTBK1-IN-3 Chemical Structure

CAS No.: 2735015-52-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

TTBK1

18 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	0.14 μM Compound: 18	Cytotoxicity against human HepG2 cells in glucose containing media incubated for 72 hrs by celltiter-glo luminescent cell viability assay Cytotoxicity against human HepG2 cells in glucose containing media incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 33944571]
HepG2	IC₅₀	0.18 μM Compound: 18	Cytotoxicity against human HepG2 cells in galactose containing media incubated for 72 hrs by celltiter-glo luminescent cell viability assay Cytotoxicity against human HepG2 cells in galactose containing media incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 33944571]

Chemical Information

CAS No. 2735015-52-6
Molecular Weight 308.34
Formula C₁₆H₁₆N₆O
SMILES

CC[C@](C)(O)C#CC1=NC=C2C=NN(C3=NC(N)=NC=C3)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Halkina T, et al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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