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Crovalimab

(Synonyms: SKY59; RO7112689; RG-6107)
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Based on 1 Customer Validation

Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research.

For research use only. We do not sell to patients.

  • Purity: 99.59%
  • CAS No.: 1917321-26-6
  • Molecular Weight:145.28 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Crovalimab
  • Experimental Validation Results for Crovalimab
  • Experimental Validation Results for Crovalimab
  • Crovalimab Chemical Structure
    Crovalimab Chemical Structure
CAS No.: 1917321-26-6
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Crovalimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Complement C5 Protein, Human (HEK293, His, HY-P700862) can bind Crovalimab. The EC50 for this effect is 5.406 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HepG2 cells with Crovalimab (HY-P99965, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/50 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Crovalimab Chemical Structure
    1/16
  • Crovalimab
  • Immobilized Complement C5 Protein, Human (HEK293, His, HY-P700862) can bind Crovalimab. The EC50 for this effect is 5.406 ng/mL.
  • Flow cytometric analysis of 1X106 HepG2 cells with Crovalimab (HY-P99965, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/50 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).