C5 - complement C5 Gene

Also Known as C5D; C5a; C5b; ECLZB; CPAMD4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 727

About C5

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,952,335-121,074,865 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 85.9) and lung (RPKM 3.7).

Summary

This gene encodes a component of the Complement System, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause Complement Component 5 deficiency, a disease characterized by recurrent Bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

C5 Products (3)

mRNA Protein Name
NM_001317163.2 NP_001304092.1 complement C5 isoform 2
NM_001317164.2 NP_001304093.1 complement C5 isoform 3 precursor
NM_001735.3 NP_001726.2 complement C5 isoform 1 preproprotein
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19528535 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
14566334 GOA
involved in positive regulation of chemokine production IDA
IDA: Inferred from direct assay
14566334 GOA
involved in positive regulation of vascular endothelial growth factor production IDA
IDA: Inferred from direct assay
14566334 GOA
Cellular Component GO Annotation Evidence References Source
part of membrane attack complex IDA
IDA: Inferred from direct assay
22832194 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C5 Protein Structure

A2M_N

A2M_N: MG2 domain (126 - 219)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (473 - 610)

ANATO

ANATO: Anaphylotoxin-like domain (698 - 732)

A2M

A2M: Alpha-2-macroglobulin family (772 - 859)

A2M_comp

A2M_comp: A-macroglobulin complement component (1052 - 1301)

A2M_recep

A2M_recep: A-macroglobulin receptor (1419 - 1509)

NTR

NTR: UNC-6/NTR/C345C module (1551 - 1658)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1676 a.a.
Protein Preferred Names Protein Names

complement C5

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

C5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
C5 P01031 PGRMC2 Homo sapiens O15173 32296183
Intra
C5 P01031 PGRMC2 Homo sapiens O15173 32296183
Intra
C5 P01031 NEMP1 Homo sapiens O14524-2 32296183
Intra
C5 P01031 NEMP1 Homo sapiens O14524-2 32296183
Intra
C5 P01031 POU6F2 Homo sapiens P78424 32296183
Intra
C5 P01031 POU6F2 Homo sapiens P78424 32296183
Intra
C5 P01031 POU6F2 Homo sapiens P78424 32296183
Intra
C5 P01031 AQP6 Homo sapiens Q13520 32296183
Intra
C5 P01031 AQP6 Homo sapiens Q13520 32296183
Intra
C5 P01031 AQP6 Homo sapiens Q13520 32296183
Intra
C5 P01031 KIR3DL3 Homo sapiens Q8N743 32296183
Intra
C5 P01031 KIR3DL3 Homo sapiens Q8N743 32296183
Intra
C5 P01031 KIR3DL3 Homo sapiens Q8N743 32296183
Intra
C5 P01031 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
C5 P01031 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
C5 P01031 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
C5 P01031 CPLX4 Homo sapiens Q7Z7G2 32296183
Intra
C5 P01031 CPLX4 Homo sapiens Q7Z7G2 32296183
Intra
C5 P01031 CPLX4 Homo sapiens Q7Z7G2 32296183
Intra
C5 P01031 EBP Homo sapiens Q15125 32296183
Intra
C5 P01031 EBP Homo sapiens Q15125 32296183
Intra
C5 P01031 EBP Homo sapiens Q15125 32296183
Intra
C5 P01031 CFHR1 Homo sapiens Q03591 19528535
Intra
C5 P01031 CFHR1 Homo sapiens Q03591
SPR
19528535
Intra
C5 P01031 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
C5 P01031 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
C5 P01031 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
C5 P01031 CREB3L1 Homo sapiens Q96BA8 25416956
Intra
C5 P01031 ANKS6 Homo sapiens Q68DC2 32296183
Intra
C5 P01031 ANKS6 Homo sapiens Q68DC2 32296183
Intra
C5 P01031 ANKS6 Homo sapiens Q68DC2 32296183
Cross
C5 P01031 vco3_najka Naja kaouthia Q91132 21217642
Intra
C5 P01031 KEL Homo sapiens P23276 32296183
Intra
C5 P01031 KEL Homo sapiens P23276 32296183
Intra
C5 P01031 KEL Homo sapiens P23276 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C5 Proteins

Cat. No. Product Name Accession Purity
HY-P7864 Complement C5a Protein, Human P01031 (T678-R751) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700862 Complement C5 Protein, Human (HEK293, His) P01031 (Q19-C1676) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700959 Complement C5a Protein, Human (His) P01031 (T678-R751) ≥ 90%, as determined by reducing SDS-PAGE.

C5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81185 C5b-9 Antibody WB, IHC-P, IHC-F, ICC/IF Human, Rat
HY-P86840 Complement C5 Antibody (YA6533) WB, ICC/IF, IHC-P, FC Human

Related Diseases

Diseases Alias
Complement Component 5 Deficiency
  • C5 Deficiency

  • C5D

Eculizumab, Poor Response To
Leiner Disease
  • Erythroderma Desquamativum

  • Complement Component 5 Deficiency

Immunodeficiency Due To A Late Component Of Complement Deficiency
  • Immunodeficiency Due To C5 To C9 Component Complement Deficiency

  • Terminal Complement Pathway Deficiency

Complement Deficiency
  • Complement Deficiency Disease

  • Hereditary Complement Deficiency Diseases

Acute Poststreptococcal Glomerulonephritis
  • Post-Streptococcal Glomerulonephritis

  • Acute Post-Streptococcal Glomerulonephritis

Hemoglobinuria
Hemolytic-Uremic Syndrome
  • Hemolytic Uremic Syndrome

  • Haemolytic-Uraemic Syndrome

  • Hus

  • Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes

  • Typical Haemolytic Uraemic Syndrome

  • Gasser Syndrome

  • Hus - [Haemolytic Uraemic Syndrome]

Meningoencephalitis
  • Acquired Toxoplasmal Meningoencephalitis

  • Meningoencephalitis Due To Acquired Toxoplasmosis

  • Meningoencephalitis Due To Toxoplasmosis

  • Toxoplasma Meningoencephalitis

Hellp Syndrome
  • Hemolysis, Elevated Liver Enzymes, Lowered Platelets

  • Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy

  • Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome

  • Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]

  • Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Hemolytic Uremic Syndrome, Atypical 1
  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical

Systemic Lupus Erythematosus
  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]

Macular Degeneration, Age-Related, 1
  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2

Membranoproliferative Glomerulonephritis
  • Mesangiocapillary Glomerulonephritis

  • Dense Deposit Disease

  • Membranoproliferative Glomerulonephritis Type 2

  • Primary Membranoproliferative Glomerulonephritis

  • Mesangiocapillary Glomerulonephritis, Type Ii

  • Glomerulonephritis, Membranoproliferative

  • Chronic Glomerulonephritis, Lobular

  • Lobular Glomerulonephritis

  • Ddd

  • Glomerulonephritis Membranoproliferative Type 2

  • Mpgn 2

  • Membranoproliferative Glomerulonephritis Type Ii

  • Mesangiocapillary Glomerulonephritis Type 2

  • Mpgn

  • Primary Mpgn

  • Glomerulonephritis Membranoproliferative

  • Membranoproliferative Glomerulonephritis, Type Ii

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus C5 VGNC VGNC:60232
Bos taurus C5 VGNC VGNC:49997
Macaca mulatta C5 VGNC VGNC:70475
Canis familiaris C5 VGNC VGNC:38595
Rattus norvegicus C5 RGD RGD:2237
Mus musculus C5 MGD MGI:96031
Others C5 NCBI