C5 - complement C5 Gene
Also Known as C5D; C5a; C5b; ECLZB; CPAMD4
Species: Homo sapiens
About C5
This gene has 13 transcripts (splice variants), 196 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 85.9) and lung (RPKM 3.7).
Summary
This gene encodes a component of the Complement System, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause Complement Component 5 deficiency, a disease characterized by recurrent Bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
C5 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001317163.2 | NP_001304092.1 | complement C5 isoform 2 |
| NM_001317164.2 | NP_001304093.1 | complement C5 isoform 3 precursor |
| NM_001735.3 | NP_001726.2 | complement C5 isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19528535 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of macrophage chemotaxis |
IDA
IDA: Inferred from direct assay
|
14566334 | GOA |
| involved in positive regulation of chemokine production |
IDA
IDA: Inferred from direct assay
|
14566334 | GOA |
| involved in positive regulation of vascular endothelial growth factor production |
IDA
IDA: Inferred from direct assay
|
14566334 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of membrane attack complex |
IDA
IDA: Inferred from direct assay
|
22832194 | GOA |
C5 Protein Structure
A2M_N: MG2 domain (126 - 219)
A2M_N_2: Alpha-2-macroglobulin family N-terminal region (473 - 610)
ANATO: Anaphylotoxin-like domain (698 - 732)
A2M: Alpha-2-macroglobulin family (772 - 859)
A2M_comp: A-macroglobulin complement component (1052 - 1301)
A2M_recep: A-macroglobulin receptor (1419 - 1509)
NTR: UNC-6/NTR/C345C module (1551 - 1658)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1676 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
complement C5 |
|
C5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
C5 | P01031 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
C5 | P01031 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
C5 | P01031 | NEMP1 | Homo sapiens | O14524-2 | 32296183 | |
|
Intra
|
C5 | P01031 | NEMP1 | Homo sapiens | O14524-2 | 32296183 | |
|
Intra
|
C5 | P01031 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
C5 | P01031 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
C5 | P01031 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
C5 | P01031 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
C5 | P01031 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
C5 | P01031 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
C5 | P01031 | KIR3DL3 | Homo sapiens | Q8N743 | 32296183 | |
|
Intra
|
C5 | P01031 | KIR3DL3 | Homo sapiens | Q8N743 | 32296183 | |
|
Intra
|
C5 | P01031 | KIR3DL3 | Homo sapiens | Q8N743 | 32296183 | |
|
Intra
|
C5 | P01031 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
C5 | P01031 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
C5 | P01031 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
C5 | P01031 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
C5 | P01031 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
C5 | P01031 | CPLX4 | Homo sapiens | Q7Z7G2 | 32296183 | |
|
Intra
|
C5 | P01031 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
C5 | P01031 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
C5 | P01031 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
C5 | P01031 | CFHR1 | Homo sapiens | Q03591 | 19528535 | |
|
Intra
|
C5 | P01031 | CFHR1 | Homo sapiens | Q03591 | 19528535 | |
|
Intra
|
C5 | P01031 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
C5 | P01031 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
C5 | P01031 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
C5 | P01031 | CREB3L1 | Homo sapiens | Q96BA8 | 25416956 | |
|
Intra
|
C5 | P01031 | ANKS6 | Homo sapiens | Q68DC2 | 32296183 | |
|
Intra
|
C5 | P01031 | ANKS6 | Homo sapiens | Q68DC2 | 32296183 | |
|
Intra
|
C5 | P01031 | ANKS6 | Homo sapiens | Q68DC2 | 32296183 | |
|
Cross
|
C5 | P01031 | vco3_najka | Naja kaouthia | Q91132 | 21217642 | |
|
Intra
|
C5 | P01031 | KEL | Homo sapiens | P23276 | 32296183 | |
|
Intra
|
C5 | P01031 | KEL | Homo sapiens | P23276 | 32296183 | |
|
Intra
|
C5 | P01031 | KEL | Homo sapiens | P23276 | 32296183 |
Recombinant C5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7864 | Complement C5a Protein, Human | P01031 (T678-R751) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700862 | Complement C5 Protein, Human (HEK293, His) | P01031 (Q19-C1676) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700959 | Complement C5a Protein, Human (His) | P01031 (T678-R751) | ≥ 90%, as determined by reducing SDS-PAGE. |
C5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81185 | C5b-9 Antibody | WB, IHC-P, IHC-F, ICC/IF | Human, Rat |
| HY-P86840 | Complement C5 Antibody (YA6533) | WB, ICC/IF, IHC-P, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Complement Component 5 Deficiency |
|
|
| Eculizumab, Poor Response To |
|
|
| Leiner Disease |
|
|
| Immunodeficiency Due To A Late Component Of Complement Deficiency |
|
|
| Complement Deficiency |
|
|
| Acute Poststreptococcal Glomerulonephritis |
|
|
| Hemoglobinuria |
|
|
| Hemolytic-Uremic Syndrome |
|
|
| Meningoencephalitis |
|
|
| Hellp Syndrome |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Systemic Lupus Erythematosus |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | C5 | VGNC | VGNC:60232 |
| Bos taurus | C5 | VGNC | VGNC:49997 |
| Macaca mulatta | C5 | VGNC | VGNC:70475 |
| Canis familiaris | C5 | VGNC | VGNC:38595 |
| Rattus norvegicus | C5 | RGD | RGD:2237 |
| Mus musculus | C5 | MGD | MGI:96031 |
| Others | C5 | NCBI |