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Cat. No.: HY-W935330

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Thalidomide-ethyne-C5-COOH

Thalidomide-ethyne-C5-COOH (Compound 68) is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC STAT3 degrader-2 (HY-153023).

For research use only. We do not sell to patients.

CAS No.: 2600541-17-9
Formula: C₂₁H₂₀N₂O₆
Molecular Weight:396.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thalidomide-ethyne-C5-COOH Chemical Structure

CAS No.: 2600541-17-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Thalidomide-ethyne-C5-COOH (Compound 68) is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTACs, such as PROTAC STAT3 degrader-2 (HY-153023)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2600541-17-9
Molecular Weight 396.39
Formula C₂₁H₂₀N₂O₆
SMILES

O=C1C2=C(C#CCCCCCC(O)=O)C=CC=C2C(N1C3C(NC(CC3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou H, et al. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. Journal of medicinal chemistry. 2019 Dec 26;62(24):11280-11300. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Thalidomide-ethyne-C5-COOH

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Thalidomide-ethyne-C5-COOH Related Classifications

HY-W935330 Related Classifications