AQP4 - aquaporin 4 Gene

Also Known as MIWC; WCH4; hAQP4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 361

About AQP4

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,852,038-26,865,803 (from NCBI)

This gene has 10 transcripts (splice variants), 250 orthologues and 11 paralogues. Biased expression in brain (RPKM 248.2) and lung (RPKM 72.5).

Summary

This gene encodes a member of the Aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant Aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

AQP4 Products (7)

mRNA	Protein	Name
NM_001317384.3	NP_001304313.1	aquaporin-4 isoform M1x
NM_001317387.3	NP_001304316.1	aquaporin-4 isoform delta4
NM_001364286.1	NP_001351215.1	aquaporin-4 isoform M23
NM_001364287.1	NP_001351216.1	aquaporin-4 isoform M23x
NM_001364289.2	NP_001351218.1	aquaporin-4 isoform M23x
NM_001650.7	NP_001641.1	aquaporin-4 isoform M1
NM_004028.5	NP_004019.1	aquaporin-4 isoform M23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19383790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA
enables water channel activity	EXP EXP: Inferred from Experiment	17178220	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	8601457	GOA
enables water channel activity	IMP IMP: Inferred from mutant phenotype	37143309	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	17645239	GOA
involved in intracellular water homeostasis	IMP IMP: Inferred from mutant phenotype	37143309	GOA
involved in multicellular organismal-level water homeostasis	IEP IEP: Inferred from expression pattern	16814974	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	19383790	GOA
involved in water transport	IDA IDA: Inferred from direct assay	8601457	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18392839	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17645239	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8601457	GOA
located in sarcolemma	IDA IDA: Inferred from direct assay	29055082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP4 Protein Structure

MIP

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
aquaporin-4	aquaporin type4

AQP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AQP4	P55087	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	AQP4	P55087	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	AQP4	P55087	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	AQP4	P55087	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	AQP4	P55087	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	AQP4	P55087	HPCAL4	Homo sapiens	Q9UM19	Y2H Prey Pooling	32296183
Intra	AQP4	P55087	HPCAL4	Homo sapiens	Q9UM19	Validated Y2H	32296183
Intra	AQP4	P55087	HPCAL4	Homo sapiens	Q9UM19	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AQP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72087	AQP4 Protein, Human (His-SUMO)	P55087-1 (C253-V323)	≥ 90%, as determined by reducing SDS-PAGE.

AQP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83459	Aquaporin 4 Antibody (YA3204)	IHC-P	Human, Rat
HY-P83459A	Aquaporin 4 Antibody	WB, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
HY-P85657	Aquaporin 4 Antibody (YA5349)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Neuromyelitis Optica	Devic Disease Devic Syndrome Neuromyelitis Optica Spectrum Disorder Devic'S Disease Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Transverse Myelitis	Myelitis Transverse Myelitis, Transverse
Optic Neuritis	Inflammatory Optic Neuropathy
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Intracranial Hypertension	Raised Intracranial Pressure
Autoimmune Disease Of Peripheral Nervous System
Cranial Nerve Disease	Cranial Nerve Disorder Disorder Of Cranial Nerve Cranial Nerve Diseases
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Balo Concentric Sclerosis	Balo'S Concentric Sclerosis Balo Disease Diffuse Cerebral Sclerosis Of Schilder Tumefactive Multiple Sclerosis Concentric Demyelination Balo'S Disease Baló Concentric Sclerosis Encephalitis Periaxialis Concentrica Marburg Variant
Internuclear Ophthalmoplegia	Ophthalmoplegia Internuclearis Bielschowsky-Lutz-Cogan Syndrome Ino - [Internuclear Ophthalmoplegia] Lhermitte Syndrome Mlf - [Medial Longitudinal Fasciculus] Syndrome Internuclear Paralysis
Acute Retrobulbar Neuritis	Retrobulbar Neuritis Retrobulbar Optic Neuritis
Spinal Cord Injury	Spinal Cord Injuries
Arachnoiditis	Spinal Arachnoiditis Adhesive Arachnoiditis Chronic Arachnoiditis Familial Spinal Arachnoiditis Arachnitis Arachnoid Inflammation
Brown-Sequard Syndrome	Brown-Squard Syndrome Hemicord Syndrome Hemiparaplegic Syndrome Hemispinal Cord Syndrome Brown-Séquard Syndrome
Neuritis	Peripheral Neuritis
Optic Papillitis	Papillitis Papilledema
Acute Disseminated Encephalomyelitis	Acute Disseminated Encephalitis Adem Ade Encephalomyelitis Acute Disseminated Encephalomyelitis, Acute Disseminated Adem - [Acute Disseminated Encephalomyelitis]
Sarcoid Meningitis	Meningitis In Sarcoidosis
Vascular Myelopathy	Vascular Myelopathies
Autoimmune Optic Neuritis
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Neurosarcoidosis	Cerebral Sarcoidosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Idiopathic Intracranial Hypertension Benign Intracranial Hypertension Iih Benign Intracran. Hypt.
Diabetes Insipidus
Acute Flaccid Myelitis
Acute Hemorrhagic Leukoencephalitis	Ahl Acute Haemorrhagic Leucoencephalitis Of Weston Hurst Leukoencephalitis, Acute Hemorrhagic Acute Hemorrhagic Encephalomyelitis Acute Necrotizing Hemorrhagic Leukoencephalitis Weston-Hurst Syndrome Ahle Acute Haemorrhagic Leucoencephalitis Hurst Disease Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal Postimmunization Or Postvaccinal Leukoencephalopathy
Obstructive Hydrocephalus
Communicating Hydrocephalus	Acquired Communicating Hydrocephalus
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Supratentorial Meningioma
Autoimmune Disease Of Central Nervous System
Central Pontine Myelinolysis	Myelinolysis, Central Pontine Osmotic Demyelination Syndrome Cpm Myelinolysis Central Pontine Central Pontine Myelinosis
Nonarteritic Anterior Ischemic Optic Neuropathy	Anterior Ischemic Optic Neuropathy Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To NAION Non-Arteritic Anterior Ischemic Optic Neuropathy Ischemic Optic Neuropathy Aion Optic Neuropathy, Ischemic Naion, Susceptibility To Optic Neuropathy, Anterior Ischemic Optic Neuropathy, Anterior Ischemic, Susceptibility To Non-Arteritic Anterior Ischaemic Optic Neuropathy Nonarteritic Anterior Ischaemic Optic Neuropathy Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To Ion - [Ischemic Optic Neuropathy] Neuropathic Ischaemia Of N.Opticus Ischaemic Neuropathy Of Optic Nerve
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Cerebritis
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Acute Necrotizing Encephalitis	Acute Necrotizing Encephalopathy Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy Ane Acute Necrotizing Encephalopathy Type 1 Adane Ane1 Autosomal Dominant Acute Necrotizing Encephalopathy Iiae3 Susceptibility To Acute Necrotizing Encephalopathy Susceptibility To Infection-Induced Acute Encephalopathy Encephalopathy, Acute Necrotizing, Susceptibility To Encephalitis, Acute Necrotizing
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Syringomyelia	Hydromyelia
Intermittent Proptosis	Intermittent Exophthalmos
Tuberculous Encephalopathy
Cranial Nerve Palsy	Cranial Nerve Paralysis Cranial Nerve Diseases Cranial Nerve Palsies
Neuroretinitis	Juxtapapillary Focal Retinitis And Retinochoroiditis Retinitis Focal Retinitis And Retinochoroiditis, Juxtapapillary Papilloretinitis
Neuroma
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Mouth Disease	Mouth Diseases Mouth Disorders
Primary Progressive Multiple Sclerosis	Ppms Primary-Progressive Ms Multiple Sclerosis, Primary Progressive
Inappropriate Adh Syndrome	Syndrome Of Inappropriate Antidiuretic Hormone Secretion Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone Siadh Syndrome Of Inappropriate Vasopressin Secretion Syndrome Of Inappropriate Secretion Of Adh Inappropriate Secretion Of Antidiuretic Hormone Syndrome Of Inappropriate Antidiuresis Siadh - [Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone] Antidiuretic Hormone Syndrome Hormone Secretion Inadequate Antidiuretic Hormone Secretion Syndrome Schwartz-Bartter Syndrome Siad - [Syndrome Of Inappropriate Antidiuresis] Hypersecretion Of Antidiuretic Hormone
Constipation
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Intracranial Arteriosclerosis
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Brachial Plexus Neuritis	Brachial Neuritis Parsonage-Aldren-Turner Syndrome
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Abducens Palsy	Sixth Nerve Palsy Abducens Nerve Palsy Abducens Nerve Disease Abducens Nerve Weakness Lateral Rectus Muscle Denervation Paresis Lateral Rectus Muscle Innervation Disorder Sixth Cranial Nerve Disorder 6th Nerve Palsy Abducens Nerve Diseases Vith Nerve Disorder Vith Nerve Paralysis Cranial Mononeuropathy Vi Cranial Nerve Vi Palsy Sixth Cranial Nerve Palsy Vi Nerve Palsy Abducens Nerve Disorder Abducens Sixth Nerve Palsy Abducens Nerve Paralysis Disease Or Disorder Of Abducent Nerve Sixth Cranial Nerve Disease Sixth Cranial Nerve Weakness Disorder Of Sixth Cranial Nerve Isolated Abducent Nerve Palsy Atrophy Of Sixth Cranial Nerve Paralysis Of Sixth Cranial Nerve
Scotoma	Enlarged Blind Spot Scotoma Of Blind Spot Area Blind Spot Area Scotoma Enlarged Angioscotoma Enlarged Paracaecal Scotoma Generalized Visual Field Contraction Or Constriction Sector Or Arcuate Visual Field Defects
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Facial Nerve Disease	Facial Nerve Disorder Facial Nerve Diseases Neuropathy Of Facial Nerve Disorders Of 7th Cranial Nerve Disorders Of The Seventh Cranial Nerve
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Papilledema	Choked Disk Edema Of The Optic Disc
Megalencephalic Leukoencephalopathy With Subcortical Cysts	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Mlc Van Der Knaap Disease Lvm Leukoencephalopathy With Swelling And Cysts Megalencephaly-Cystic Leukodystrophy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome Infantile Leukoencephalopathy And Megalencephaly Leukoencephalopathy With Swelling And A Discrepantly Mild Course Vacuolating Leukoencephalopathy Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystrophy Syndrome Van Der Knaap Syndrome Leukoencephalopathy, Megalencephalic, With Subcortical Cysts
Facial Paralysis	Facial Palsy Bell Palsy
Branch Retinal Artery Occlusion	Retinal Artery Occlusion Arterial Retinal Branch Occlusion Retinal Arterial Branch Occlusion
Toxic Optic Neuropathy
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Subacute Delirium	Delirium Acute Confusional State Nos
Demyelinating Polyneuropathy	Peripheral Demyelinating Neuropathy Demyelinating Peripheral Neuropathy
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Autoimmune Disease Of Exocrine System
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Demyelinogenic Leukodystrophy Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Peripheral Vertigo	Vertigo, Peripheral
Secondary Progressive Multiple Sclerosis	Secondary-Progressive Ms Spms Multiple Sclerosis, Chronic Progressive Chronic Progressive Multiple Sclerosis Multiple Sclerosis, Secondary Progressive
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Progressive Multifocal Leukoencephalopathy	Pml Leukoencephalopathy, Progressive Multifocal Progressive Multifocal Leukoencephalitis Leukoencephalopathy Progressive Multifocal Pml - [Progressive Multifocal Leukoencephalopathy]
Chickenpox	Varicella Varicella Nos
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Visual Pathway Disease	Disorder Of Visual Pathways
Ocular Motility Disease	Ocular Motility Disorders Abnormality Of Eye Movement Disorder Of Eye Movements Eye Movement Disorder Eye Movement Disorders
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Acquired Color Blindness	Acquired Color Vision Deficiencies Acquired Color Vision Deficiency Acquired Colour Blindness Acquired Colour Vision Deficiencies Acquired Colour Vision Deficiency
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115460	AER-271		96.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W008574	TGN-020		99.97%	Unkown
HY-W008574A	TGN-020 sodium		99.96%	Unkown
HY-W176557	TGN-073		99.53%	Unkown
HY-P10936A	AQP4 (201-220) TFA		99.91%	Unkown
HY-N10756	Hyp9	Agonist	99.90%	Unkown
HY-N4246	Bacopaside I		99.20%	Unkown
HY-157226	ORI-TRN-002	Inhibitor	98.13%	Unkown
HY-RS00876	AQP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W017091	3-Phenoxy-1,2-propanediol	Inhibitor	95.0%	Unkown
HY-18805	Nicotinanilide	Inhibitor	99.84%	Unkown
HY-P10936	AQP4 (201-220)		/	Unkown
HY-P10937	AQP4 (205-215)		/	Unkown
HY-P10937A	AQP4 (205-215) TFA		/	Unkown
HY-RS16702	Aqp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23136	Aqp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991869	Aquaporumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AQP4	VGNC	VGNC:38018
Mus musculus	AQP4	MGD	MGI:107387
Bos taurus	AQP4	VGNC	VGNC:26047
Rattus norvegicus	AQP4	RGD	RGD:2143
Macaca mulatta	AQP4	VGNC	VGNC:69993
Felis catus	AQP4	VGNC	VGNC:80422
Others	AQP4	NCBI