SF 11
Based on 1 Customer Validation
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity.
For research use only. We do not sell to patients.
- Purity: 98.76%
- CAS No.: 443292-81-7
- Formula: C27H30N2O2S
- Molecular Weight:446.60
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Obesity Compound Library
HY-L087
-
Antidepressant Compound Library
HY-L108
-
Heterocyclic Compound Library
HY-L138
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
-
GPCR/G Protein Compound Library
HY-L006
-
Neuronal Signaling Compound Library
HY-L013
All Neuropeptide Y Receptor Isoforms
More
Biological Activity
|
NPY Y2 receptor 199 nM (IC50) |
Chemical Information
-
CAS No. 443292-81-7
-
Appearance Solid
-
Molecular Weight 446.60
-
Formula C27H30N2O2S
-
Color White to off-white
-
SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL (559.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
Handling Instructions (2659 KB)
References
[1]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463. [Content Brief]
[2]. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2391 mL | 11.1957 mL | 22.3914 mL | 55.9785 mL |
| 5 mM | 0.4478 mL | 2.2391 mL | 4.4783 mL | 11.1957 mL | |
| 10 mM | 0.2239 mL | 1.1196 mL | 2.2391 mL | 5.5979 mL | |
| 15 mM | 0.1493 mL | 0.7464 mL | 1.4928 mL | 3.7319 mL | |
| 20 mM | 0.1120 mL | 0.5598 mL | 1.1196 mL | 2.7989 mL | |
| 25 mM | 0.0896 mL | 0.4478 mL | 0.8957 mL | 2.2391 mL | |
| 30 mM | 0.0746 mL | 0.3732 mL | 0.7464 mL | 1.8660 mL | |
| 40 mM | 0.0560 mL | 0.2799 mL | 0.5598 mL | 1.3995 mL | |
| 50 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 60 mM | 0.0373 mL | 0.1866 mL | 0.3732 mL | 0.9330 mL | |
| 80 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL | 0.6997 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2239 mL | 0.5598 mL |
SF 11 Related Classifications
HY-107731 Related Classifications
Powered by Bioz