U 80493

Cat. No.: HY-183886: Data Sheet Handling Instructions
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U 80493 is a HIV-1 reverse transcriptase inhibitor with IC₅₀ of 20 μM. U 80493 can be used for the research of acquired immunodeficiency syndrome.

For research use only. We do not sell to patients.

U 80493 Chemical Structure

CAS No. : 136816-67-6

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
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Description

U 80493 is a HIV-1 reverse transcriptase inhibitor with IC₅₀ of 20 μM. U 80493 can be used for the research of acquired immunodeficiency syndrome^[1].

IC₅₀ & Target^[1]

HIV-1

20 μM (IC₅₀)

In Vitro

U 80493 (Compound 8) inhibits HIV-1 IIIb replication in MT-2 cells with an ED₅₀ of 2 μM and has a CC₅₀ of 15 μM^[1].
U 80493 inhibits HIV-1 D34 replication in PBMC with an ED₅₀ of 1-10 μM and has a CC₅₀ greater than 10 μM^[1].
U 80493 inhibits HIV-1 IIIb replication in H9 cells with an ED₅₀ of 1 μM and has a CC₅₀ of 10 μM^[1].
U 80493 inhibits recombinant HIV-1 RT activity with an IC₅₀ of 20 μM^[1].
U 80493 (100 μM) inhibits recombinant HIV-1 RT activity by 73%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.49

Formula

C₂₁H₃₀N₄O

CAS No.

136816-67-6

SMILES

CCNC1=CC=CN=C1N2CCN(CC2)CC3=CC(C)=C(OC)C(C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu H, et al. Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1). Mini Rev Med Chem. 2010;10(1):62-72. [Content Brief]

U 80493 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U 80493136816-67-6U80493U-80493HIVReverse TranscriptaseHuman immunodeficiency virusH9 cellsHIV-1 D34HIV-1 reverse transcriptaseHIV-1 IIIbPBMCrecombinant HIV-1 RTMT-2 cellsacquired immunodeficiency syndromeInhibitorinhibitorinhibit

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