UDP-Glucosamine
UDP-Glucosamine is a sugar nucleotide analog, glycosyl donor, and metabolite of D-galactosamine (HY-42682). UDP-Glucosamine provides Glucosamine (HY-B1125) for the synthesis of Dolichyl monophosphate glucosamine, inhibits the synthesis of Dolichyl monophosphate glucose, Dolichyl monophosphate mannose, and Dolichyl pyrophosphate (GlcNAc)2, sequesters Dolichyl monophosphate, and acts as a glycosyl donor in chicken embryo and rat liver microsomal preparations. UDP-Glucosamine can be used in studies related to influenza virus infection.
For research use only. We do not sell to patients.
- CAS No.: 17479-04-8
- Formula: C15H25N3O16P2
- Molecular Weight:565.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
UDP-Glucosamine (30 min) supports the synthesis of Dol-P-GlcN in rat liver microsomes, and the addition of exogenous Dol-P increases its incorporation by more than 4-fold[1].
UDP-Glucosamine (10-200 μM) inhibits the synthesis of Dol-P-Glc, Dol-P-Man, and Dol-PP-(GlcNAc)2 in microsomes of primary chicken embryo cells, among which the synthesis of Dol-PP-(GlcNAc)2 is the most sensitive to it, and exogenous Dol-P reverses this inhibitory effect[1].
UDP-Glucosamine competes with UDP-Glucose for Dol-P-Glc synthesis in vitro; at a high UDP-GlcN:UDP-Glc concentration ratio, its maximum inhibition rate of this reaction reaches 73% in rat liver microsomes and 56% in microsomes of primary chick embryo cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 17479-04-8
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Molecular Weight 565.32
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Formula C15H25N3O16P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)N)(O)=O)(O)=O)O2)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UDP-Glucosamine Related Classifications
HY-W1139983 Related Classifications
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- UDP-Glucosamine
- 17479-04-8
- Drug Metabolite
- Nucleoside Antimetabolite/Analog
- chick-embryo cell microsomes
- dolichyl monophosphate glucosamine
- dolichyl monophosphate mannose
- dolichyl pyrophosphate (GlcNAc)2
- influenza virus
- glycosyltransferase
- dolichyl monophosphate glucose
- GlmU
- UDP-Glc: Dol-P glucosyltransferase
- rat liver microsomes
- Inhibitor
- inhibitor
- inhibit