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Cat. No.: HY-19446

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UK-371800

UK-371800 is a highly selective PDE5 inhibitor (IC₅₀ = 4.2 nM). UK-371800 has good permeability and is not affected by the efflux of P-glycoprotein.

For research use only. We do not sell to patients.

CAS No.: 247582-13-4
Formula: C₂₃H₃₃N₇O₅S
Molecular Weight:519.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

UK-371800 Chemical Structure

CAS No.: 247582-13-4

Size

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Quantity

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

UK-371800 is a highly selective PDE5 inhibitor (IC₅₀ = 4.2 nM). UK-371800 has good permeability and is not affected by the efflux of P-glycoprotein^[1].

IC₅₀ & Target^[1]

PDE5

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 247582-13-4
Molecular Weight 519.62
Formula C₂₃H₃₃N₇O₅S
SMILES

O=C1C2=NN(C)C(CC)=C2NC(C3=CC(S(=O)(N4CCN(CC)CC4)=O)=CN=C3O[C@H](C)COC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bunnage ME, et al. Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6033-6. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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