2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. UR-11353

UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice.

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UR-11353

UR-11353 Chemical Structure

CAS No. : 138060-13-6

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UR-11353 Related Antibodies

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Description

UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice[1].

In Vitro

UR-11353 (Compound 4e) potently and selectively inhibits platelet activating factor (PAF)-induced aggregation in rabbit platelet-rich plasma with an IC50 of 0.012 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UR-11353 Related Antibodies
In Vivo

UR-11353 (Compound 4e) (1 mg/kg; i.v.; single dose) exhibits potent, long-lasting protection against PAF-induced mortality in mice, with 48% protection maintained 24 hours after a single 1 mg/kg i.v. dose and an ID50 of 0.023 mg/kg i.v[1].
UR-11353 (i.v.; single dose) exhibits protection against PAF-induced hypotension with an ID50 of 0.025 mg/kg in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PAF-induced Swiss mice (male, 22-26 g)[1]
Dosage: 1 mg/kg
Administration: i.v.; single dose
Result: Achieved 100% protection against PAF-induced mortality at 0.5, 2, 3, and 5 hours post-administration.
Achieved 95% protection against PAF-induced mortality at 7 hours post-administration.
Achieved 81% protection against PAF-induced mortality at 17 hours post-administration.
Achieved 48% protection against PAF-induced mortality at 24 hours post-administration.
Exhibited an ID50 of 0.023 mg/kg i.v. for inhibition of PAF-induced mortality.
Molecular Weight

611.30

Formula

C34H59ClN2O5
CAS No.
SMILES

O=C(N(CC1=[N+](CC)C=CC=C1)C(C)=O)OCC2COC(C2)OCCCCCCCCCCCCCCCCCC.[Cl-]
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Purity & Documentation
References
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UR-11353 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UR-11353138060-13-6UR11353UR 11353Platelet-activating Factor Receptor (PAFR)rabbit platelet-rich plasmaarachidonic acidmiceplatelet aggregationPAFhypotensionplatelet activating factorADPnormotensive ratsInhibitorinhibitorinhibit

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