Inflammation/Immunology
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Inflammation/Immunology Related Products (20798)
Related Products (20798)
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Antibodies (115)
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Related Compound Screening Libraries (4)
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3-Acetylumbelliferyl β-D-Glucopyranoside
0 ImagesCat. No.: HY-W357142CAS No.: 20943-16-23-Acetylumbelliferyl β-D-Glucopyranoside is a fluorogenic substrate for β-glucosidase and can be used as a positive control substrates for β-D-glucosidase.
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Retinoic acid-HSA
0 ImagesCat. No.: HY-NP0245Retinoic acid-HSA is a conjugate of Retinoic acid (HY-14649) and Human serum albumin (HSA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the primary epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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MBP (83-99)
0 ImagesCat. No.: HY-P3723CAS No.: 178823-45-5MBP (83-99) is a MBP-specific T cell lines recognizing the immunodominant epitope. MBP (83-99) induces proliferation and IFN-γ secreting of T cells.
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COX-2-IN-70
0 ImagesCat. No.: HY-189356COX-2-IN-70 is an orally active and selective COX-2 inhibitor with an IC50 of 1.86 μM. COX-2-IN-70 reduces the production of prostaglandins and thromboxanes by inhibiting the COX-2 isoenzyme. COX-2-IN-70 can be used for inflammation research.
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NLRP3-IN-32
0 ImagesCat. No.: HY-161329NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling.
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(Rac)-Isogosferol
0 ImagesCat. No.: HY-N17579CAS No.: 152441-79-7Synonyms: (Rac)-Isogospherol(Rac)-Isogosferol ((Rac)-Isogospherol) is a furanocoumarin present in the fruits of Cnidium monnieri(L.) Cusson.
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α-Glucosidase-IN-3
0 ImagesCat. No.: HY-146981CAS No.: 2758286-48-3α-Glucosidase-IN-3 is an oleanolic acid (OA) oxime ester derivativ eagainst α-glucosidase(IC50=0.35 µM) and α-amylase.
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SB772077B
0 ImagesCat. No.: HY-123958CAS No.: 785774-34-7SB772077B is a ROCK inhibitor. SB772077B has an anti-inflammatory activity and enhances aqueous outflow facility (OF) by inactivating RhoA/ROCK signal pathway. SB772077B significantly reduces the mRNA level of β-catenin and protein level of fibrotic markers, such as vinculin, fibronectin, collagen 1 A and vimentin. SB772077B also has vasodialatory activity and decreases pulmonary and systemic blood pressure. SB772077B can be used for glaucoma research and pulmonary hypertensive disorder research.
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Mefenamic acid-13C6
0 ImagesCat. No.: HY-B0574S2CAS No.: 1325559-19-0Mefenamic acid-13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a BBB-permeable non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
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INX-SM-6
0 ImagesINX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS.
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Goat IgG Fab fragment
0 ImagesCat. No.: HY-NP0197B
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Flupirtine-d4 hydrochloride
0 ImagesSynonyms: D 9998-d4 hydrochlorideFlupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis.
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Vapitadine hydrochloride
0 ImagesCat. No.: HY-14939ACAS No.: 279253-83-7Vapitadine hydrochloride (Compound 3a) is a selective, orally active and nonsedating antihistamine agent, which exhibits a good binding affinity with human cloned histamine H1 receptor with a Ki of 19 nM. Vapitadine hydrochloride decreases the histamine-induced lethality (ED50 is 0.056-1.2 mg/kg), antagonizes the cutaneous reactions to histamine (ED50 is 0.51-1.4 mg/kg) in rats.
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Antioxidant agent-20
0 ImagesCat. No.: HY-170579Antioxidant agent-20 (Compound 3d) has potent anti-inflammatory and antioxidant activity. Antioxidant agent-20 reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 exhibits photoprotective effect against UVB-irradiated human skin keratinocytes (HaCaT) (IC50=5.13 µM) via activation of Nrf2/HO-1 signaling and inhibition of NF-κB pathway.
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RAGE406R
0 ImagesCat. No.: HY-178926CAS No.: 3034560-21-6RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of CCL2, TNF, and IL-6 in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes.
